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Stem cells grow new hair – Chinese translation

Authorsgammon
Date

January 27, 2015

用干细胞促生毛发

在一项新的研究中,桑福德 – 伯纳姆的研究人员利用人类多能干细胞促生出新的头发。该研究代表了以细胞为基础的治疗人类脱发的第一步。仅在美国,就有超过4000万男性和21万女性有着脱发困扰。这项研究在PLOS ONE在线发表。 

您的资助很重要。请帮助捷列克博士继续这项研究!

“我们已开发出一种使用人类多能干细胞的方法,来创造能够引发人体毛发生长的新的细胞。该方法相对于目前那种依赖于将毛囊从头的一个部位移植到另一个部位的方法有显着的改善,”阿列克谢-捷列克博士说。身为桑福德 – 伯纳姆的研究院发展、老化、再生项目副教授的捷列克博士还指出:“我们的干细胞的方法为移植提供了无限多的来自病人的细胞源,而不受现有的毛囊的限制。” 

该研究小组开发了促使多能干细胞成为真皮毛乳头细胞的程序。真皮毛乳头细胞是一种调节毛囊形成和生长周期的独特细胞。如果只靠本身的话,毛乳头细胞并不适合于头发移植,原因是:它们的采集量不够,而且在采集后便很快失去其诱导毛囊形成的能力。 

“对成人来说,真皮毛乳头细胞不易在体外扩增,而且会很快失去它们的生发功能,”捷列克博士说。他还说:“我们开发了一个驱动人类多能干细胞分化为毛乳头细胞的程序,并通过移植到小鼠身上的实验证实了它们的生发能力。” 

“我们的下一个步骤是将那些由人类多能干细胞衍生出的人类真皮毛乳头细胞移植回人体。目前,我们正在寻求合作伙伴来实现这最后一步。” 

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Using stem cells to grow new hair

Authorsgammon
Date

January 27, 2015

In a new study, Sanford-Burnham researchers have used human pluripotent stem cells to generate new hair. The study represents the first step toward the development of a cell-based treatment for people with hair loss. In the United States alone, more than 40 million men and 21 million women are affected by hair loss. The research was published online in PLOS ONE.

“We have developed a method using human pluripotent stem cells to create new cells capable of initiating human hair growth. The method is a marked improvement over current methods that rely on transplanting existing hair follicles from one part of the head to another,” said Alexey Terskikh, PhD, associate professor in the Development, Aging, and Regeneration Program. “Our stem cell method provides an unlimited source of cells from the patient for transplantation and isn’t limited by the availability of existing hair follicles.”

The research team developed a protocol that coaxed human pluripotent stem cells to become dermal papilla cells. They are a unique population of cells that regulate hair-follicle formation and growth cycle. Human dermal papilla cells on their own are not suitable for hair transplants because they cannot be obtained in necessary amounts and rapidly lose their ability to induce hair-follicle formation in culture.

“In adults, dermal papilla cells cannot be readily amplified outside of the body and they quickly lose their hair-inducing properties,” said Terskikh. “We developed a protocol to drive human pluripotent stem cells to differentiate into dermal papilla cells and confirmed their ability to induce hair growth when transplanted into mice.”

“Our next step is to transplant human dermal papilla cells derived from human pluripotent stem cells back into human subjects,” said Terskikh. “We are currently seeking partnerships to implement this final step.”

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11th annual Christopher Reeve “Hot Topics” in stem cell biology

Authorsgammon
Date

November 11, 2014

On November 17, 2014, an evening of data “blitzes” on stem cell science will be presented at the 11th Annual Christopher Reeve Satellite Symposium at the Society for Neuroscience (SFN). The Symposium is a three-hour event with presentations by thought leaders delivered in a rapid, enjoyable, no-nonsense fashion with the latest controversies and insights in stem cell biology—with emphasis on fundamental biology. Continue reading “11th annual Christopher Reeve “Hot Topics” in stem cell biology”