Uncategorized Archives - Sanford Burnham Prebys
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Kevin Tharp awarded $450,000 Ovarian Cancer Research Alliance grant to break down tumor defenses

AuthorCommunications
Date

June 16, 2026

The new award will fund research regarding how to bust through the barrier between tumors and immune cells

Kevin Tharp, PhD, was awarded a three-year, $450,000 Ovarian Cancer Research Alliance grant to study high grade serous ovarian cancer, the most common and deadly form of the disease. 

In collaboration with researchers at the University of California San Diego, Tharp recently published findings in Cell Reports demonstrating a treatment approach in mice that allowed more tumor-fighting immune cells to approach tumors, shifted the behavior of other immune cells to work against tumors, and made immunotherapy more effective.

Tharp will use the new funding to follow up on these findings regarding how high grade serous ovarian cancer circumvents the immune system’s anti-tumor defenses. His team will focus on the physical barrier that tumors build to keep immune cells at bay.

“We know that tumors can wall themselves off with structural collagen proteins that resemble scar tissue, and that the presence of this obstacle determines the effectiveness of anti-cancer immunotherapies,” said Tharp.

“We want to know how and why tumors create this obstruction and understanding this will help us find ways to break through these defenses to make immunotherapies more effective.”

Tharp will conduct this research under the mentorship of Cosimo Commisso, PhD, the deputy director of the NCI-Designated Cancer Center at Sanford Burnham Prebys and a professor in the Cancer Metabolism and Microenvironment Program, and David Schlaepfer, PhD, a professor in the department of OBGYN and Reproductive Sciences at the University of California San Diego Moores Cancer Center.

“Too many ovarian cancer patients progress and do not respond to the standard of care, so finding new treatments is an extreme clinical need,” said Tharp.

“There is potential for immunotherapies to treat recurrent and metastatic cancer if we can bridge the divide between tumors and immune cells.”

The Ovarian Cancer Research Alliance is the oldest and largest ovarian and gynecologic cancer charity in the world. Since its founding in 1994, the alliance has grown into the leading non-government funder of ovarian and related gynecologic cancer research by investing more than $140 million in grants to scientists.

Institute News

Q & A with Postdoctoral Researcher Kokila Shankar, from the Sheffler Lab

AuthorCommunications
Date

June 15, 2026

Meet one of our early-career scientists at Sanford Burnham Prebys Medical Discovery Institute: Kokila Shankar, PhD, a postdoctoral researcher in the lab of Douglas Sheffler, PhD. Shankar studies the brain stress signaling system to develop potential treatments for drug addiction.

When and how did you become interested in science?
WMy dad works in science, so I grew up seeing a little bit of that world. Within science, he works on the industry side which provided me with a perspective on how drug discovery works.

While I always liked science growing up, what really hooked me is when I learned about the field of neuroscience. You have to incorporate a lot of different types of knowledge to really understand neuroscience and neurobiology. And it’s one of the fields where I think that no matter how much we study it, there’s always going to be room to learn more and more.

What are the key areas of research you focus on?
I am really excited about the fact that I get to work in small molecule drug discovery for neurological and psychiatric disease. Currently, my focus is on treating drug addiction.

We use a drug discovery workflow to be able to take biological targets we’ve identified and develop small molecule chemicals that modify these targets. Essentially, we’re working on ways to either increase or decrease the activity of these targets as a strategy to potentially mitigate drug addiction symptoms.

More specifically, my main project is targeting the brain stress signaling system. By developing a small molecule that modulates a stress signaling receptor and some of its associated proteins, our goal is to change stress signaling in the brain. This is important because stress signaling is very involved in addiction. It can play a large role in people becoming addicted to substances and making their addiction worse and harder to quit.

What motivates you about your research?
I think in the field of drug discovery, people tend to portray making new medicines as a linear path. We have a small molecule identified through a screen that we know has some effects on a biological target. Then we just have to make it better, put it in cells, then in animals and finally we get it approved to put into people.

The reality is that there are so many things that can affect every single stage of that workflow. And there’s a lot of troubleshooting and interdisciplinary collaboration involved in keeping things on track. So even when things aren’t going smoothly, I remember that what I signed up to do as a scientist is solve problems. Each time we solve one, we also learn something new and that keeps me very motivated.

What do you like about working here?
Sanford Burnham Prebys feels like a very focused place to do research. Everyone’s goal is to work together to drive research forward. And you really feel that through the resources that are available, whether that’s the core facilities or the number of people that are available to collaborate or share reagents.

On top of that, the community here is very welcoming. Everyone is collaborative and wants to see each other succeed. And that’s rare to find in an academic research environment.

Kokila Shankar photo collage

What are your career goals?
My goal is to transition to a role in biotech or the pharmaceutical industry. And it would be even better if I was able to work in neuroscience therapeutics development.

Beyond that, I think a special aspect of being in science, earning a PhD and completing postdoctoral training is that it all prepares you for so many different types of careers. That could mean staying at the bench in R&D or moving into areas such as business, communications and marketing or science policy.

I feel like I’m very fortunate that there’s a lot of opportunities, and I don’t want to close the door on any of them.

What do you enjoy doing when you’re not in the lab?
I am an active volunteer with the Fleet Science Center, so I love doing their K-12 and their adult outreach programs to get more people excited about science.

Also, I used to be a competitive ballroom dancer. Right now, I’m enjoying the opportunity to work with students at the University of California San Diego to help them improve. And hopefully one day I’ll step back into competition.

Postdocs at Sanford Burnham Prebys are pushing the boundaries of science every day through curiosity, collaboration, and innovation. This series highlights their unique journeys, what inspires their work, and the impact they’re making across our labs.

Explore the Full Series

Institute News

Science in Pictures

AuthorCommunications
Date

June 15, 2026

Confocal microscopy reveals human hair follicles growing from a stem cell-derived organoid (cyan) with nerves (red).

Image courtesy of Karl R. Koehler and Jiyoon Lee.

Institute News

Science in Pictures

AuthorCommunications
Date

June 8, 2026

Depicted in this confocal/deconvolution micrograph are the actin cytoskeleton (cyan) and the endoplasmic reticulum (red) of a mouse brain cancer cell.

Image courtesy of Halli Lindamood and Eric Vitriol.

Institute News

Sanford Burnham Prebys recognizes 10 doctoral degree recipients

AuthorCommunications
Date

June 3, 2026

The Institute’s Graduate School of Biomedical Sciences held its third Commencement ceremony to celebrate new alumni

The Sanford Burnham Prebys Medical Discovery Institute’s Graduate School of Biomedical Sciences hosted 10 recent doctoral degree recipients and their family members, friends and colleagues during the school’s third annual Commencement ceremony on May 29, 2026.

These new graduates join the ranks of Institute scientists and alumni that have propelled 50 years of discovery at Sanford Burnham Prebys and 20 years of graduate education.

The graduation ceremony was held at the Institute’s La Jolla campus in the Victor E. LaFave III Memorial Auditorium.

“As you reflect on your first days as a graduate student, I hope you recognize how far you have come, not only as scientists, but also as thinkers, collaborators, mentors and individuals,” said Alessandra Sacco, PhD, the dean of the Sanford Burnham Prebys Graduate School of Biomedical Sciences and a professor in the Center for Cardiovascular and Muscular Diseases.

“The growth you have demonstrated through this remarkable journey is extraordinary, and today we celebrate both your accomplishments and the dedication that made them possible. It has been an honor to be part of your journey.”

Following her remarks, Sacco introduced David Brenner, MD, the president and CEO of Sanford Burnham Prebys.

“Yesterday, you were graduate students, today you are graduates and tomorrow you are alumni,” Brenner said. “I want you to feel like this is your second home where you’ll return as peers and colleagues to tell us about your triumphs and contribute to our seminars and symposia as active members of our community.” 

Following Brenner’s comments, Michaela Romero, PhD ’25, spoke on behalf of her fellow graduates.

“Here at Sanford Burnham Prebys, we’ve been immersed in a culture of collaboration where science is not a solo act,” Romero said. “This has not happened by accident and has been built one conversation at a time. 

“Cultures like this need to be nurtured with care, so I hope you create something that feels just as special as this place wherever you go in the future.” 

Romero turned the podium over to Cosimo Commisso, PhD, the deputy director of the Institute’s NCI-Designated Cancer Center and a professor in the Cancer Metabolism and Microenvironment Program, who provided the Commencement address.

Commisso spoke about the importance of carefully contemplating the motivation behind your science and how it can change over time, which he punctuated with a story from his scientific journey about an event he attended for pancreatic cancer patients, survivors and their family members.

“I gave myself permission to evolve and realized that I wanted to dedicate my life’s work specifically to pancreatic cancer research,” he said. “If something like this happens to you, if such an event impacts you in a profound way, I hope you listen to your internal compass and remember that what motivates you today at graduation may likely look very different years later. 

“Evolution of your ‘why’ is a feature and not a bug,” he added. “Let your own ‘why’ be the force that pushes you beyond the familiar to make a difference.”

Diane Klotz, PhD, the chief learning officer at Sanford Burnham Prebys, then provided attendees an overview of the meaning of the hoods and symbols that are used in Commencement ceremonies. She asked faculty members to place the doctoral academic hoods upon the graduates to signify completion of their degrees.

This year, the following graduates were acknowledged:

  • Adarsh Rajesh, PhD ’25, who trained in the Adams lab and was hooded by Peter Adams, PhD, director of and professor in the Cancer Genome and Epigenetics Program
  • Sviatlana Zaretski, PhD ’25, who trained in the Adams lab and was hooded by Adams
  • Yu-Ling (Linda) Chang, PhD ’26, who trained in the Colas lab and was hooded by Alexandre Colas, PhD, associate dean of admissions in the Graduate School of Biomedical Sciences and associate professor in the Center for Cardiovascular and Muscular Diseases
  • Michaela Romero, PhD ’25, who trained in the Colas lab and was hooded by Colas
  • Jiaqian (Emily) Wu, PhD ’25, who trained in the Cosford lab and was hooded by Nicholas Cosford, PhD, professor in the Cancer Metabolism and Microenvironment Program
  • Ximena Diaz-Olea, PhD ’25, who trained in the Ronai lab and was hooded by Andrei Osterman, PhD, her thesis committee chair, vice dean and associate dean of curriculum of the Graduate School of Biomedical Sciences and a professor in the Center for Metabolic and Liver Diseases
  • Cedomir Stamenkovic, PhD ’25, who trained in the Sacco lab and was hooded by Sacco
  • Rema Iyer, PhD ’25, who trained in the Deshpande lab and was unable to attend the ceremony
  • Utkarsha Hemant Paithane, PhD ’26, who trained in the Bagchi lab and was unable to attend
  • Ruslan Nuryyev, PhD ’26, who trained in the Snyder lab and was unable to attend

Graduate school vice dean Osterman provided the ceremony’s closing remarks.

“What is happening today is because of your genuine accomplishment and is a product of your creativity, genius, effort and everything you invested in the research project that you completed,” Osterman said. 

“Now you will take all you have learned during your time here and choose your own path forward, and a new and exciting adventure begins.”

Institute News

Science in Pictures

AuthorCommunications
Date

June 1, 2026

Darkfield microscopy captures the flowing grace of sperm from Drosophila virilus, a species of fruit fly.

Image courtesy of Earl Nishiguchi.

Institute News

David A. Brenner appears on nation’s longest running community podcast

AuthorCommunications
Date

May 27, 2026

Hosted by Drew Schlossberg, Spotlight on the Community is the nation’s longest running community podcast, now going on 20+ years.

Recently, David Brenner, MD, president and CEO of Sanford Burnham Prebys Medical Discovery Institute, appeared on the podcast to discuss the mission of the Institute, its research collaborations, the role of AI and the current state of biomedical research locally and beyond.

 You can hear Brenner’s podcast interview on Spotify,  Apple and iHeart platforms.

Institute News

Science in Pictures

AuthorCommunications
Date

May 25, 2026

A human fibroblast—the most common cells of connective tissue—undergoes mitosis or cell division. Cell components include actin (gray/brown), myosin II (green) and DNA (magenta).

Image courtesy of Nilay Taneja.

Institute News

Women in Science Lecture series spotlights structural biology and immunology leader

AuthorCommunications
Date

May 21, 2026

The series highlights the groundbreaking work and unique perspectives of women leaders in the biomedical sciences.

On May 13, 2026, Sanford Burnham Prebys Medical Discovery Institute hosted the third event in the Women in Science Lecture Series. The first featured speaker was Erica Ollmann Saphire, PhD, MBA, professor, president and CEO of the La Jolla Institute for Immunology.

Saphire told the audience about a turning point in 2013 in her field studying how antibodies work against the Ebola virus. Antibodies are especially important treatments for infectious diseases that lack an effective vaccine, as was the case for the Ebola virus until 2019. Saphire described the challenge that emerged when an antibody predicted to be effective based on laboratory results had no effect on survival in animal studies, whereas a cocktail of three antibodies that was ineffective in laboratory cell culture tests actually protected every animal against the infection.

“Collectively, as a body of scientists, it became clear we were missing some information about how to study the neutralizing effects of antibodies,” said Saphire. “The key was seeing the clue that how well the treatment protected was dependent on what kind of cell it was made in and how that effected the antibodies’ ability to recruit the immune system.”

To enable experiments following up on that lead, Saphire organized a large coalition of academic, industrial and government labs from across the world. Each partner sent their antibodies or neutralization assays to a single location where they could be studied side by side under code names to protect intellectual property. The consortium fast-tracked a smaller study that led to the first therapeutic approved for treating Ebola, and the longer-term comprehensive study would go on to develop much better therapeutics for the disease. Due to this initiative’s success, Saphire was asked to lead a Gates Foundation-supported project to evaluate antibody therapeutics against SARS-CoV-2.

Saphire closed her presentation with her reflections on how to improve the scientific system so that it works better for researchers.

Kelly Kersten and Erica Ollmann Saphire with fireside chat moderator and cardiovascular researcher Sanjeev Ranade, PhD. Image credit: Sanford Burnham Prebys.

Kersten and Saphire with fireside chat moderator and cardiovascular researcher Sanjeev Ranade, PhD. Image credit: Sanford Burnham Prebys.

“I’ve learned over 20 years that a siloed approach very much gives a siloed answer,” Saphire said. “It is important to find out how different experts’ interests and motivations align and intersect and then put resources behind that to find success.”

Sanjeev Ranade, PhD, assistant professor in the Center for Cardiovascular and Muscular Diseases at Sanford Burnham Prebys, then moderated a fireside chat and audience question-and-answer session with Saphire and Kelly Kersten, PhD, assistant professor in the Cancer Metabolism and Microenvironment Program at the Sanford Burnham Prebys NCI-Designated Cancer Center. Topics included: the remarkable power and complexity of the immune system; the contrast in needing to mitigate the immune system in allergies and autoimmune disease versus boosting it in the right ways in cancer and infectious disease; how to effectively introduce your work to people outside of science; how roles change as academic and leadership careers progress; and advice for students and trainees beginning their careers in biomedical research.

The Women in Science Lecture Series features events that are free and open to the public. The series is part of broader efforts at Sanford Burnham Prebys to foster an environment that nurtures the success of individuals from all backgrounds. The events are hosted by the Office of Workforce Engagement & Belonging and highlight the groundbreaking work and unique perspectives of women leaders in the biomedical sciences, while fostering mentorship and collaboration across the Torrey Pines Mesa.

Registration is open for the next event in the series on October 14, 2026.

Institute News

Science in Pictures

AuthorCommunications
Date

May 18, 2026

A micrograph depicts the hippocampal region of the human brain. Located in the medial temporal lobe, it acts as a crucial component of the limbic system for learning, memory and spatial navigation.

Image courtesy of Sarah Moghadam and Ahmad Salehi.