Uncategorized Archives - Sanford Burnham Prebys
Institute News

LEAP scholars share research and celebrate a year of growth

AuthorCommunications
Date

June 16, 2025

Last week, scholars in the LEAP (Lab Experience As Pathway) program shared their research at a capstone presentation event, marking the culmination of a year-long journey in the lab. Designed to bridge the gap between college graduation and graduate school, the LEAP program provides recent grads with hands-on research experience, professional development, and mentorship to prepare them for advanced studies in STEM.

The program was first launched by Dr. Ani Deshpande and has since been championed by Dr. Kevin Yip, who continues to lead and shape its success. With generous support from the Prebys Foundation, the LEAP program is led by the Sanford Burnham Prebys NCI-designated Cancer Center, with significant contributions from the Office of Education, Training and International Services (OETIS), Workforce Engagement and Belonging (WEB), a dedicated team of mentors, and many other Sanford Burnham Prebys colleagues.

In his closing remarks, Dr. Deshpande reflected on the purpose and promise of the program. “This is about you,” he told the scholars. “Your energy, your growth, your potential. I’ve been so impressed by your scientific curiosity and your confidence.”

Dr. Yip added, “It’s been a privilege to work with such a talented and motivated group. Watching them grow as scientists and individuals over the past year has been truly inspiring.”

As the event wrapped up, students headed to a poster session and photo session with plenty to celebrate: a year of lab experience, new skills, and a clearer path to graduate school and beyond.

The LEAP program students include:
Emerald Adeyan (Chavez and Heynen-Genel Labs)
Developing an Innovative Assay for High-Throughput Detection of ecDNA in MYC-Amplified Medulloblastoma
Kyle Alvarez (Jackson and Sinha Labs)
Tissue Morphology Predicts Telomere Shortening in Human Tissues​
Monica Jensen (Huang Lab)
Development and Validation of TREM2 Overexpression Lines in H9 Embryonic Stem Cells
Rachel Khoury  (Wang Lab)
Motor Neuron Rewiring in Aging & Cachectic Muscle Wasting Conditions​
Kai Rauda (Osterman Lab)
Skin-Deep Discovery: A Novel Vitamin C Metabolic Pathway in Cutibacterium acnes​
Sarina Safavi (Yip Lab)
Exploring Differential Expression in Alzheimer’s Disease Resilience​
Isabel Sakowicz (Kumsta and Tharp Labs)
Glucose-Driven Fibrotic Pathways: Connecting Metabolic Stress to Ovarian Fibrosis​
Mahek Shah (Spruck Lab)
Validating F5446 as an Inducer of Viral Mimicry in Human Breast Cancer Cells​

Institute News

Science in Pictures

AuthorScott LaFee
Date

June 16, 2025

A micrograph using confocal, fluorescence and image stacking technologies depicts the optic nerve head of a rodent. Astrocytes in yellow, contractile proteins in red and vasculature in green.

Image courtesy of Hassanin Qambari and Jayden Dickson, Lions Eye Institute, Australia.

Institute News

Science in Pictures

AuthorScott LaFee
Date

June 9, 2025

A darkfield image of a mammal heart.

Image courtesy of Hillary Guzik, Rochester Institute of Technology.

Institute News

Sanford Burnham Prebys celebrates newest graduate school alumni

AuthorGreg Calhoun
Date

June 4, 2025

The Institute’s Graduate School of Biomedical Sciences held its second Commencement ceremony to celebrate four recent graduates

Family, friends and colleagues gathered at the end of May 2025 to applaud the four newest alumni of the Sanford Burnham Prebys Graduate School of Biomedical Sciences. These early-career scientists are the latest graduates to leave their mark on the institute and carry forth the graduate program’s motto, “Knowledge is the power to heal.”

On Friday, May 30, 2025, the Graduate School of Biomedical Sciences held its graduation ceremony at the institute’s La Jolla campus in the Victor E. LaFave III Memorial Auditorium.

“Each of you has made significant contributions to your field of science, created new knowledge and demonstrated the ability to perform independent research,” said Alessandra Sacco, PhD, dean of the institute’s graduate school and professor and director of the Development, Aging and Regeneration Program in the Center for Cardiovascular and Muscular Diseases.

“Today, we celebrate not only your academic journey, but also your years of dedication to get to this point, and the perseverance and intellectual curiosity that enabled you to reach this milestone.”

Following her remarks, Sacco introduced Ryan Loughran, PhD ’24, to speak on behalf of his fellow graduates.

“Graduate school is an experience unlike any other,” said Loughran. “You’re constantly drinking from a fire hose, learning new techniques, running experiments, coding data pipelines, writing and reviewing papers, preparing posters and giving talks.

‘I came to realize that it’s overwhelming by design. Somewhere in that chaos, something incredible happens. You’re forged by the fire. You begin to absorb information with an insatiable hunger. You think more critically and more creatively when confronting problems, and that is the true gift of the PhD experience.”

Loughran turned the podium over to Guy Salvesen, PhD, the inaugural dean of the graduate school, who provided the Commencement address.

“The graduates in front of you display the success of the program,” he said. “More importantly and more fundamentally, though, they have reached this milestone based on the merits of the hard-won accomplishments that they share with their mentors.”

Diane Klotz, PhD, chief learning officer at Sanford Burnham Prebys, then discussed the meaning of the hoods and symbols that are used in Commencement ceremonies. She invited the graduates forward and instructed faculty members to adorn them with the doctoral academic hoods signifying completion of a PhD program.

This year, the following graduates were recognized:

Andrei Osterman, PhD, the graduate school’s vice dean and associate dean of curriculum and a professor in the Center for Metabolic and Liver Diseases, provided the ceremony’s closing remarks.

“While today is primarily a celebration of individual intellectual achievements, it also recognizes your meaningful contributions to and interactions with the scientific community,” he said. “You have grown through peer review and collaborating with others, and these experiences will benefit you wherever your career takes you.”

More on this year’s graduates

Zong Ming Chua, PhD ’24, was born in Singapore. He developed a deep and early interest in biology after reading Darwin’s seminal work “On the Origin of Species” and various books by Richard Dawkins.

At Sanford Burnham Prebys, Zong Ming investigated the mechanisms that link cellular senescence and epigenetics. He discovered a new role of the histone variant H2A.Z R80C. He found that the histone variant influenced the transcriptomic profile of senescent cells.

Zong Ming moved to the Bay Area after graduating and is currently a computational biologist at GigaGen.

Jordan Friedlein, PhD ’24, was born and raised in Minnesota. From an early age, he expressed a desire to understand how the world worked. In high school, biology and physiology were his favorite classes.

Jordan joined the Bagchi Lab in 2019 and worked on investigating the role of circular RNA derived proteins in Myc-driven cancers. During his five years, Jordan enjoyed contributing to cutting-edge research and building lasting relationships with other grad students and institute members.

Ryan Loughran, PhD ’24, was born and raised in Greensburg, Penn. Growing up in a family with four generations of pharmacists, Ryan always imagined following in their footsteps and taking over the family-owned Loughran’s Pharmacy.

However, his path took a different turn during his undergraduate studies when he had the opportunity to spend a summer in New York City as an intern in the Emerling lab at Weill Cornell Medicine. He later moved with Emerling to help establish her new lab at Sanford Burnham Prebys as her lab manager. He later joined the Emerling lab as a graduate student.

Ryan plans to undertake a short postdoctoral position before transitioning into the pharmaceutical industry, where he aims to apply his knowledge and experience in cancer research to real-world applications.

Zhouting Zhu, PhD ’24, grew up in Changzhou city in the Jiangsu province of China. After completing a Master of Science in Surgery degree from Nanjing University in 2018, Zhouting joined the graduate program at Sanford Burnham Prebys.

She conducted her doctoral research in the lab of Tariq Rana, PhD, an educational affiliate professor in the Graduate School of Biomedical Sciences. Zhouting focused on RNA biology and cancer immunotherapy. Her work explored immune cell dynamics in tumors and spleens under various treatment conditions in mouse cancer models.

Zhouting is currently working toward MD-equivalency certification, with the long-term goal of becoming a board-certified physician-scientist.

Institute News

Science in Pictures

AuthorScott LaFee
Date

June 2, 2025

Purkinje neurons are located in the cerebellar cortex of the brain. With their flask-shaped cell bodies, many branching dendrites and a single long axon, these cells are essential for controlling motor activity.

Image courtesy of Thomas Deerinck, NCMIR, UC San Diego.

Institute News

Evan Snyder named Fellow of the Child Neurology Society

AuthorScott LaFee
Date

May 28, 2025

Evan Snyder, MD, PhD, professor in the Center for Neurologic Diseases, has been named a Fellow of the Child Neurology Society, honoring a distinguished career and significant contributions in the field of child neurology.

Snyder, who is also a member of the Cancer Genome and Epigenetics Program at Sanford Burnham Prebys, is a longtime leader in pediatric neuroscience and stem cell research. He joined Sanford Burnham Prebys in 2003, and was founding director of its original Stem Cell Research Center.

The Child Neurology Society is a professional organization whose mission is to promote the optimal care of children with neurological and developmental disorders by providing education, advocacy and support for clinicians and researchers in the field.

Snyder was cited for his clinical expertise, research contributions and ongoing commitment to the mission of the Society. He is featured in the second edition of Child Neurology: Its Origins, Founders, Growth and Evolution, a collection of biographies detailing the lives of innovators in child neurology throughout history.

Institute News

Scientists and podcasters

AuthorGreg Calhoun
Date

May 27, 2025

Sanford Burnham Prebys scientists bring dramatic stories of scientific achievement to life

In March 2025, Sanford Burnham Prebys scientists Ani Deshpande, PhD, and Pamela Itkin-Ansari, PhD, launched a new podcast exploring groundbreaking discoveries in science and medicine. The initial episodes have garnered rave reviews, including being hailed as “masterpieces” by upcoming podcast guest Adam Heller, PhD, the scientist and inventor who revolutionized blood sugar testing and laid the groundwork for modern continuous glucose monitoring systems.

On the first episode of The Discovery Dialogues Podcast, the hosts examined early descriptions of diabetes across ancient civilizations. Deshpande and Itkin-Ansari traced the research that led to the discovery of insulin and to life-saving treatment for diabetes.

Following its discovery as a treatment for diabetes, insulin had to be purified from millions of animal carcasses. In the follow-up episode, the podcasters discussed the race to make human insulin using genetic engineering, including interviews with Keiichi Itakura, PhD, a key member of the historic team that created the first synthetic gene to make human insulin, and Herb Boyer, PhD, the scientist who founded the first biotech company called Genentech and brought insulin to millions of patients.

Ani Deshpande, PhD, profile photo

Ani Deshpande, PhD, is an associate professor in the Cancer Genome and Epigenetics Program at Sanford Burnham Prebys.

Pamela Itkin-Ansari, PhD, profile photo

Pamela Itkin-Ansari, PhD, is an adjunct professor in the Center for Cardiovascular and Muscular Diseases at Sanford Burnham Prebys.

Last week, Deshpande and Itkin-Ansari released their third episode detailing animals that use insulin as venom and highlighting an animal that can sense low blood sugar faster than a machine.

We recently sat down with them to learn more about their motivations and creative process.

What is your origin story as scientists turned podcasters?

DESHPANDE: I have been very interested in communicating science for quite some time. And I think it is important for more scientists to speak in a way that all people can understand, and to embrace new ways of communicating.

I got especially excited to talk about the incredible potential of GLP-1 drugs such as Ozempic and Wegovy, but I don’t think you can properly understand them without a grasp of diabetes. I decided to tackle diabetes as the podcast’s first topic, and I reached out to Pam as a partner with complementary expertise.

ITKIN-ANSARI: I have done a lot of scientific outreach in the past as a diabetes scientist, including with the La Jolla Playhouse and Fleet Science Center, so I jumped at the opportunity. As it turns out, Ani and I are kindred spirits in terms of our desire to help people understand how biomedical research has changed the world.

What is your process for developing each episode?

DESHPANDE: We have a very elaborate process for deciding on each episode’s topic. outlining the chapters or segments and then passing drafts back and forth until we’ve refined them into a version that is both accurate and entertaining.

ITKIN-ANSARI: Getting that balance right is so important. I’m a Radiolab junkie. I have to hear every episode. The reason I keep coming back is because I get to learn something new and have a ton of fun along the way.

DESHPANDE: It is important to us that we’re not just telling stories people already know, so we take our time to find fascinating stories about the science and the personalities behind the discoveries.

How much research goes into making the podcast?

DESHPANDE: We just read and read and read and read. Then, we bounce ideas off each other to see what makes it into an episode.

ITKIN-ANSARI: The other thing is fact-checking. We feel it our job as card-carrying scientists to be as thorough as we can be to get the facts right.

While writing for the first three episodes, what information or stories surprised you?

ITKIN-ANSARI: For me, I was amazed by the venoms of the cone snail that have already led to an FDA-approved drug for severe pain and may also revolutionize diabetes treatment.

DESHPANDE: I think it’s surprising that diabetes had been described in detail more than three millennia ago. Many of our audience members told us they were surprised by that fact as well.

What teasers can you share about future episodes?

ITKIN-ANSARI: For an upcoming episode, a legendary scientist who changed diabetes care forever after surviving the Holocaust and making his way to the U.S.

DESHPANDE: One of the most fascinating things we will cover in our future episodes and that will surprise most people is that many of the most influential drugs in the history of medicine have come from plant poisons and animal venoms. It blows my mind, and I hope our listeners will also find it to be amazing.

Listeners can find The Discovery Dialogues Podcast on Spotify, Apple Podcasts and Amazon Music. The YouTube version includes on-camera interviews and additional illustrations.

Institute News

Science in Pictures

AuthorScott LaFee
Date

May 26, 2025

The developing nervous system in the eye of a 7-day-old chick embryo.

Image courtesy of Elkhan Yusifov and Martina Schaettin, University of Zurich/Nikon Small World.

Institute News

For Many Researchers, Help Wanted Comes From Distant Locales

AuthorCommunications
Date

May 20, 2025

In his latest letter examining the effects and ramifications of the Trump administration’s assault on science, President and CEO David Brenner, MD, of Sanford Burnham Prebys discusses how other countries recruiting US-based scientists to work or start their careers elsewhere, with greater support and scientific freedom.

You can read Dr. Brenner’s letter here, plus earlier letters and other materials related to Research in Crisis.

Institute News

Science in Pictures

AuthorScott LaFee
Date

May 19, 2025

The abdominal skin of a tick engorged with blood. The ridged construction of the skin allows feeding ticks to expand up to 100 times their body weight.

Image courtesy of Theo Theune, Oost-Souberg, Zeeland, The Netherlands/Nikon Small World.