events Archives - Page 8 of 10 - Sanford Burnham Prebys
Institute News

2018 Fishman Award Ceremony honors postdoctoral scholars

AuthorSusan Gammon
Date

September 26, 2018

More than 100 supporters of SBP came out to celebrate this year’s Fishman Award recipients: Usue Etxaniz Irigoien, PhD, Koen Galenkamp, PhD, Laura Martin-Sancho, PhD, and Ee Phie Tan, PhD The annual awards ceremony, held September 20 at the Sanford Consortium, recognizes postdocs who have made extraordinary efforts and encourages their passion for careers in science.

The evening began with a warm welcome from founder Reena Horowitz, who described how she began the Fishman Fund with the late Mary Bradley (her dear friend) to honor Dr. William and Lillian Fishman. The Fishmans were the founders of SBP and firmly believed in helping young postdoctoral scientists become great principal investigators—and these awards help boost young researchers to meaningful careers in science.

Jeanne Jones, the Fishman Fund’s co-founder designee, shared that since the fund’s inception, 64 recipients have been awarded. The career development awards—bestowed annually to three postdocs—provide a generous $10,000 stipend to allow them to attend workshops and travel to national and international conferences to learn the latest developments in their research fields. Additionally, a Fishman Fund Fellowship Award, which provides salary support for two years in addition to benefits and a career-development stipend, was awarded this year for the second time in SBP history.

The keynote speaker was Aman Mann, PhD, who won the Fishman Award in 2011. Today, Mann is a research assistant professor at SBP and an entrepreneur and founder of AivoCode, a neuroscience company that licenses technology originally developed at SBP. Mann reflected on how the award gave him added confidence and resources to pursue his career goals—and he encouraged this year’s recipients to similarly follow their dreams.

If you are interested in donating to the Fishman Fund, click here.

The 2018 Fishman Fund Fellowship winner, Usue Etxaniz Irigoien, PhD, was presented with her award by Reena Horowitz. Irigoien, originally from the Basque region of Spain, is the first in her family to pursue a graduate degree in science. She is currently a postdoctoral researcher in the laboratory of Lorenzo Puri, PhD, and is studying the communication between nerves and muscles. Irigoien’s research is providing insights that may lead to improved therapies for neuromuscular diseases such as ALS. In the future, she hopes to become a principal investigator of her own lab.

The Fishman Fund Awardees:

Koen Galenkamp, PhD, was presented with his award by Andrew Viterbi, a distinguished scientist and former SBP trustee. Galenkamp works in the laboratory of Cosimo Commisso, PhD, and specializes in seeking ways to starve pancreatic tumors of the food they need to survive and grow. Originally from Amsterdam, Galenkamp thanked his colleagues and wife—who is also a postdoc in San Diego—and shared his plans to use the funds to attend a comprehensive pancreatic cancer conference at Cold Spring Harbor Laboratories.

Laura Martin-Sancho, PhD, a postdoc in the lab of Sumit Chanda, PhD, received her Fishman Fund Award from Armi Williams, a Fishman Fund Board member and longtime SBP supporter. Martin-Sancho is working to develop antiviral medicines that will combat infectious diseases such as influenza, dengue, and West Nile and Zika viruses. Martin-Sancho’s career goal is to be an independent investigator in an academic organization. She will use her stipend to attend a Keystone RNA virus conference in Dublin, Ireland.

Ee Phie Tan, PhD, originally from Malaysia, joined SBP in 2016 to work in the lab of Malene Hansen, PhD Tan is studying autophagy—a cell process that tidies up cell debris and recycles parts to maintain health. Defects in autophagy are linked to many aging-related diseases such as Alzheimer’s and Parkinson’s disease, and even cancer. Tan received her award from Reena Horowitz and will use the funds to attend a Gordon Research Conference in Texas and a Keystone Symposium in Santa Fe, New Mexico. 
 

Institute News

Duc Dong honored at Alagille Syndrome Alliance Gala

AuthorSusan Gammon
Date

July 10, 2018

Associate Professor Duc Dong, PhD, was the guest of honor at the Gala of Dreams, the inaugural fundraiser for the Alagille Syndrome Alliance held June 30 at the San Diego Marriott Del Mar. Dong is a trailblazer in the field of Alagille syndrome research—he is working toward a cure for the extremely rare genetic condition that affects approximately one in 30,000 births.

Babies born with Alagille syndrome have too few bile ducts—which are essential for the transport of waste out of the liver. This causes toxins build up in the liver and throughout the body, leading to constant severe itching, and more critically, liver damage and failure. Alagille syndrome patients also have many other life-threatening developmental defects in other parts of their bodies, including the heart, kidneys, vertebrae, and blood vessels. There is no cure for this debilitating disease, and up to 50 percent of patients eventually need a liver transplant, often during childhood.

Dong and his team have been studying JAGGED1, the gene implicated in Alagille syndrome. Taking advantage of an unusual animal model, the zebrafish, he has been able to uncover a novel genetic mechanism for the disease—opening new potential therapeutic avenues. Further, his team has surprisingly discovered that the bile ducts lost can be regenerated after turning the affected gene back “on.”

“The implication is that these developmental defects in Alagille syndrome patients could potentially be reversible and therefore curable,” says Dong. “We will now start screening for drugs that may be used to restore the function of this genetic pathway and hopefully allow for these lost bile ducts to regenerate. We will continue to challenge the science of Alagille syndrome to move closer to a cure.”

The theme of the event, “The Dawn of a Dream,” signified new advances in Alagille syndrome research and the anniversary of the organization’s 25th year in existence. The evening gave advocates, families, doctors and pharma representatives an opportunity to interact in a fun, casual setting and participate in a silent auction to raise money for research. Dong’s lab was presented with the Champion of Alagille Syndrome Award and funds raised by the Alliance through crowd sourcing.

Institute News

Highlights from the 2018 Faculty Retreat

AuthorSusan Gammon
Date

June 4, 2018

SBP’s annual Faculty Retreat was held May 30–31 in beautiful Carlsbad, California.

This year’s theme was “Fundamental Cellular Processes in Health and Disease,” and featured 20 speakers from SBP areas of expertise:

·         Development and Aging — Malene Hansen, PhD, Lorenzo Puri, MD, PhD, Karen Ocorr, PhD, Alexey Terskikh, PhD, and Rolf Bodmer, PhD

·         Immunity and Inflammation Rob Weschler-Reya, PhD, Linda Bradley, PhD, Scott Peterson, PhD, and Jeff Smith, PhD

·         Technology Platforms — Dorit Hanein, PhD, Sumit Chanda, PhD, and Niels Volkmann, PhD

·         Drug and Disease Targets — Michael Jackson, PhD, Garth Powis, PhD, Wanda Reynolds, PhD, Elena Pasquale, PhD, and Matt Peroski, PhD

·         Share Resources Update — Craig Hauser, PhD

Special congratulations to Duc Dong, PhD, and Crystal Zhao, PhD, both of whom were officially promoted to associate professors.

Faculty promotion
Pictured (left to right): Duc Dong, PhD, Elena Pasquale, PhD and Crystal Zhao PhD

Dong, in the Human Genetics Program, is advancing research in cell/organ replacement therapy that may ultimately benefit patients with diabetes and Alagille syndrome—a genetic disorder that can affect the liver, heart and other parts of the body.

Zhao, in the Tumor Initiation and Maintenance Program, is studying the regulation of neural stem cells—research that may lead to therapies for neurological diseases, including Alzheimer’s disease, Parkinson’s disease, and mental health disorders that affect cognitive abilities.

A highlight of the annual retreat is the presentation of the “WOW” award, which stands for Wonderful Original Work. This year, the WOW was given to Robert Wechsler-Reya, PhD, who won for his presentation titled “Overcoming Immune Evasion in Pediatric Brain Tumors.”

Wechsler-Reya’s research goal is to advance immunotherapy for medulloblastoma tumors—the most common malignant brain tumor in children. By increasing certain cell surface molecules called MHC on these cancer cells, he believes he can improve the ability of T cells to recognize the tumors and kill them.

Wechsler-Reya is a professor in the Tumor Initiation and Maintenance Program at SBP and is also the program director for the Joseph Clayes III Research Center for Neuro-Oncology and Genomics at Rady Children’s Institute for Genomic Medicine.

Cosimo Commisso, PhD, and Crystal Zhao, PhD, served as faculty organizers.

And many thanks to Wendy Lyon and Nelson, the research administrative specialists who organized the event.

Institute News

Cancer immunology symposium highlights hot area in cancer research

AuthorSusan Gammon
Date

March 19, 2018

The Cancer Immunology and Tumor Microenvironment Symposium held at Sanford Burnham Prebys Medical Discovery Institute (SPB) on March 8, 2018 attracted a full house of international attendees.

Its success likely stems from the impressive roster of speakers invited by Carl Ware, PhD, director of the Infectious and Inflammatory Diseases Center and Linda Bradley, PhD, also a professor in that program. The presenters included many thought leaders in the field from such prestigious institutions as University of Pittsburgh, University of Ontario Fred Hutchinson Cancer Research Center, the Mayo Clinic, Moores Cancer Center at UC San Diego and University of Washington School of Medicine.

Today, immunotherapy is one of the most exciting areas of new discoveries and treatments for many types of cancer. Although huge strides have been made—some patients experience complete remission—more breakthroughs are needed. Some patients do not respond at all, some relapse and others experience undesirable, often life-threatening side effects. And some cancers, such a pancreatic, brain, breast and prostate, have shown very limited benefit.

“This symposium brings experts in the fields of cancer and immunology together to promote scientific exchange and collaboration,” says Ware. “It’s meetings like this that will help us accelerate the understanding and development of new immune system-based therapies for cancer patients.”

Institute News

SBP brings science to San Diego community at STEM

AuthorSusan Gammon
Date

March 8, 2018

STEM Expo Day kicked off a week-long festival on Saturday, March 3, 2018 at Petco Park. The event marked the 10th annual San Diego Festival of Science and Engineering Expo Day—one of the largest STEM (Science, Technology, Engineering and Math) festivals in the U.S. The community outreach event provided learning and hands-on activities for students in grades kindergarten through 12th grade, as well as adults and families to ignite their passion for STEM education.

“STEM Expo is a great way to get our future researchers excited about science, and I believe that’s why SBP’s involvement continues to expand,” said Karen Ocorr, PhD, an SBP faculty member who organized a research demonstration for the exhibit booth.

About 40 SBP volunteers, including faculty, postdocs, staff and graduate students, worked in three shifts throughout the day to talk with visitors and guide them through two sets of interactive programs.

Ocorr set up a station where children received paper lab coats with personalized name tags to explore the food preferences of fruit flies and how it affects their heart health. Visitors used microscopes and high-powered LED magnifying glasses to look at fly abdomens to see if they had eaten sugar (dyed red) or fat (dyed blue). Not surprisingly, the fruit flies prefer a high sugar diet. Ocorr shared videos of beating fly hearts showing that both high sugar and high fat are bad for heart function.

The second station gave visitors an opportunity to interact with models of drugs and human proteins made by a 3D printer, courtesy of Adam Godzik, PhD, director of the Bioinformatics and Structural Biology Program at SBB. Godzik’s lab also brought glasses for viewing a virtual reality program showing how protein folding configurations are used to design drugs.

The event, which was free and open to the public, had more than 130 interactive exhibits with hands-on learning activities.

In spite of rain an estimated 25,000 people participated in EXPO Day at Petco Park.

Institute News

Spectacular 2017 SBP annual Gala celebrates “Sights Set on Discovery”

AuthorHelen Hwang
Date

October 18, 2017

Friends and supporters of Sanford Burnham Prebys Medical Discovery Institute (SBP) gathered under the stars on Harbor Island in downtown San Diego for our spectacular Annual Gala, themed “Sights Set on Discovery.” Raising money to advance biomedical research inspired a warm, jubilant evening as guests celebrated SBP’s many scientific accomplishments. 

In a unique setting, supporters enjoyed a jazz trio in an outdoor reception on a glittering barge on the water. Then, guests moved inside to an elegant ballroom for the program. Guests included the Institute’s namesakes T. Denny Sanford and Malin Burnham.

SBP President Kristiina Vuori, MD, PhD kicked off the program with an inspirational speech about SBP’s reputation as a global leading research Institute. She also honored the outstanding career of one of SBP’s longest-serving scientists José Luis Millán, PhD, whose research on calcification is leading to therapies for heart disease, kidney failure and other devastating disorders. His work resulted in the discovery of a new drug at our own on-site Conrad Prebys Center for Chemical Genomics and is now being tested in humans.

Three of SBP’s preeminent scientists spoke about how philanthropy bridges the gap between basic biomedical research, drug discovery and patient therapeutics.

The researchers introduced a touching video about how their own personal experiences—whether as patients themselves or first-hand witnesses to the devastating effect on loved ones—drives them to work tirelessly on the research they do at SBP. Guests then raised their paddle for a successful Fund-A-Need.

Following the dinner, the party continued on the outdoor patio, boogying to music from The Mighty Untouchables.

The Gala raised around $500,000 for biomedical research. SBP guests had a marvelous time, dancing under the stars and raising money for a noble cause—to “transform the future of human health,” as Dr. Vuori put it.

Click the SBP Facebook album to see photos from the event.  

Click on the SBP YouTube channel to see the touching video guests watched at the Annual Gala.

If you would like to donate to SBP, click Donate now

Institute News

2017 Fishman Fund Award Ceremony celebrates postdoctoral scholars

AuthorHelen I. Hwang
Date

September 20, 2017

More than 100 supporters of Sanford Burnham Prebys (SBP) Fishman Fund Awards came out to honor this year’s Fishman Fund Award recipients: David Sala Cano, PhD, Michael J. Stec, PhD, and Jose Luis Nieto Torres, PhD, at the Sanford Consortium on Tuesday evening.

Malin Burnham, SBP’s Honorary Board Trustee, spoke about SBP exemplifying collaboration as part of its DNA. He also said that of all the organizations he works with, he gets the most satisfaction from being involved with SBP. Dr. Torres received the award and Fishman Fund medallion from Burnham, while Torres’ parents watched on with pride. They flew in from Spain, visiting the United States for the first time.

Fishman Fund co-founders and SBP supporters Reena Horowitz and Jeanne Jones led the ceremonies as they spoke about the founding of the Fishman Fund Award in 2001. The Fishman Fund Career Development Awards have grown from a $1,500 allowance to $10,000 stipends for each recipient so they can attend workshops, network and travel to national and international scientific conferences to learn about the latest developments in their research fields. The generosity of Fishman Fund donors enables such important career advancement opportunities for future scientific leaders.

Greg Lucier, former SBP board member and CEO of NuVasive, Inc., also spoke on the topic of “we versus me,” emphasizing the importance of teamwork. SBP supporters Dr. Andrew Viterbi, co-founder of Qualcomm, and Armi Williams, Fishman Fund Advisory Board member and former SBP trustee, presented Fishman Fund awards and medallions to Drs. Stec and Cano, respectively.

This year’s recipients gave short presentations on their work, each of which dealt with aging, including muscle stem cells, muscle regeneration and autophagy (body’s ability to eliminate waste and recycle). Read more about their work below.

Your contributions provide vital support for the Fishman Fund. Please donate now.

2017 Fishman Fund Awardees:

David Sala Cano, PhD, a postdoctoral scholar in the laboratory of Alessandra Sacco, PhD, is working on muscle stem cells. He focuses on muscle wasting, a major health problem that leads to poor quality to life, and is associated diseases such as diabetes, chronic kidney disease, cancer and aging. He is working on identifying new targets for drugs that may prevent skeletal muscle degeneration.

Dr. Cano comes to La Jolla from a small town of Abrúcies, Spain. He holds degrees from the University of Barcelona, including a BS degree in biochemistry, a MS degree in physiology and a PhD in biomedicine. His goal is to become a principal investigator in an academic setting, combining his passion for research and teaching.

Michael J. Stec, PhD, focuses on understanding the mechanisms regulating stem cell function and skeletal muscle regeneration; he is also in the laboratory of Alessandra Sacco, Ph.D. He aims to develop novel therapies for improving muscle function in aged and diseased individuals.

Dr. Stec hails from Whippany, New Jersey. He holds a BS degree in health and exercise science from the College of New Jersey, a MS degree in exercise science from Bloomsburg University of Pennsylvania and a PhD in pathobiology and molecular medicine from the University of Alabama in Birmingham. Ultimately, his career goal is to obtain a position in the biotech industry.

Jose Luis Nieto Torres, PhD, is a postdoctoral scholar in the laboratory of Malene Hansen, PhD He conducts research on autophagy—a process our bodies use to eliminate cell waste by recycling debris into usable sources of energy. Our bodies need to be able to eliminate debris that accumulates over time and make new components for proper functioning. Autophagy declines with aging, and is associated with many age-related diseases.

Dr. Torres joined SBP from Palencia, Spain. He obtained his BS degree in biochemistry and biology from the University of Salamanca and MS and PhD degrees in molecular biology from the Universidad Autonoma de Madrid. In the future, Dr. Torres aims to become a principal investigator of his own lab in an academic setting.

 

 

 

 

 

 

Institute News

Showing kids why mutants matter at the STEM Expo

AuthorJessica Moore
Date

March 7, 2017

Want to see some mutant worms? If you do, you’re like the hundreds—or possibly thousands—of children and their parents who visited the Sanford Burnham Prebys Medical Discovery Institute (SBP) booth at the STEM Expo, held Saturday, March 4 to kick off the San Diego Festival of Science and Engineering.

Those families got to watch live C. elegans—tiny worms used at SBP to study the biology of aging—move under a magnifying glass. By comparing normal worms to mutants that don’t move as well, they learned about how a single change to DNA can have a huge impact on how a whole body works. Scientists from the lab of Malene Hansen, PhD, associate professor at SBP, who provided the worms, explained how mutations in the same gene also cause human diseases like Ehlers-Danlos syndrome, which involves hyperflexible joints and skin.

They also had the chance to use virtual reality headsets to look at the shapes of proteins—the machines that make things happen inside cells—and how they can change as a result of a mutation. The 3D visualization tool was created by the lab of Adam Godzik, PhD, professor and director of the Bioinformatics and Structural Biology Program at SBP. Researchers from Godzik’s group told visitors about how they use similar computer modeling to find new mutations that could be important in cancer.

Kids left the SBP booth with temporary DNA tattoos on their hands (or sometimes their faces), mini lab coats personalized on the spot so they could pretend to be scientists at home and, maybe, a newfound interest in biology, thanks to the enthusiasm of the Institute’s many volunteers.

Institute News

First scientific meeting on Alagille syndrome sparks hope for a cure

AuthorKristen Cusato
Date

February 28, 2017

“My child is 4 years old. Can we have a playdate?” said one parent of a child with Alagille syndrome to another.

That kind of connection was a bonus of the 8th Annual Rare Disease Day symposium, held on February 24th at Sanford Burnham Prebys Medical Discovery Institute (SBP) in La Jolla.  The focus this year was Alagille syndrome (ALGS), a genetic disorder that affects one in 30 thousand births. ALGS primarily affects bile ducts in the liver, but can also damage the heart, kidney and other parts of the body. It can cause painful body itching as toxins are released into the bloodstream because they’re not absorbed and processed by the liver. Many patients require a liver transplant to survive.

Symposium chair Duc Dong, PhD, assistant professor at SBP, created an event that brought researchers and medical doctors from all over the world together for the first time to talk about new perspectives, ideas and collaborations that offer fresh hope for these patients and their families.

“We want patients and families to know there are a lot of people working on this,” Dong said. “When all these researchers and clinicians come together, we see hope that this disease can be conquered.”

Scientists shared two decades of Alagille syndrome research, including the advances and challenges. Cindy Luxhoj, executive director of the Alagille Syndrome Alliance talked about the Alagile Warriors, a group of patients with the disorder. Some have passed away, and others battle the disease every day. A young woman who has Alagille shared what it’s like to live with the disorder, and how important it is to bridge the gap between patients and researchers.

“That’s what this was all about,” Dong said. “We hope the information that comes out of this meeting pushes us over the edge and help us find a cure for Alagille.”

In photo: Assistant Professor Duc Dong, PhD, (left) with Alagille syndrome patient Kashton (center) and his parents

Institute News

Reena Horowitz honored at Sanford Burnham Prebys Medical Discovery Institute

AuthorHelen I. Hwang
Date

December 13, 2016

During a special end-of-the-year gathering, Reena Horowitz was honored for her hard work and dedication to Sanford Burnham Prebys Medical Discovery Institute (SBP). Held in the Fishman Auditorium at SBP, friends and staff thanked Horowitz with a bouquet of flowers, applause and a speech from Kristiina Vuori, PhD, president of SBP. Vuori thanked Horowitz for being a “leading ambassador for the Institute.”

In Vuori’s speech, she explained how Horowitz became involved with the Institute through her friendship with her neighbor Lillian Fishman. Dr. William T. Fishman and his wife, Lillian Fishman, founded SBP forty years ago. “Reena’s friendship with Lillian provided the Institute with a champion in the community, as well as the development of two of SBP’s institutional programs, the Fishman Fund Awards and the Group of 12 & Friends. Reena co-founded and has managed both of these extraordinary programs for over a decade,” said Vuori.

To nurture the careers of future scientific trailblazers at SBP, the Fishman Fund was established by SBP supporters Mary Bradley and Reena Horowitz to honor the founders of the Institute, Dr. William and Lillian Fishman. Over 55 postdoctoral students have been supported by the Fishman Fund, which awards postdoctoral fellowships and career development grants.

Horowitz co-founded G12 & Friends, a lecture and get-together with friends hosted monthly at SBP. What started out as Horowitz, Lillian Fishman and a few friends has ballooned into a group that usually draws over 100 guests, curious about a wide range of topics from science, medicine and the arts.

The celebration was an occasion to thank Horowitz for being a passionate supporter of SBP’s scientific programs within the community.

To find out more about the Fishman Fund and how to support it, click here.