Malene Hansen Archives - Sanford Burnham Prebys
Institute News

Year in review: Top stories in 2017

AuthorSusan Gammon
Date

January 9, 2018

In the last 12 months, SBP scientists published 338 scientific papersthat’s almost a paper a day. We are proud of this impressive achievement, and equally proud of the quality of research in these scientific studies. Whether you are seeing them for the first time or coming back for another look, check out the most popular stories from SBP’s researchers in 2017.

  1. Scientists take a deeper dive into cellular trash
    Malene Hansen, PhD, led the first-ever comprehensive analysis of autophagy in a living animal during aging. The study was published in eLIFE.  
     
  2. Drug short-circuits cancer signaling
    A drug that zeroes in on mutated nuclear receptors found in cancer will soon be entering Phase 1 clinical trials at the Dana Farber Cancer Center for patients with colorectal cancer. Research by Xaio-kun Zhang, PhD, describes how the targets cancer but leaves normal proteins alone.
     
  3.  Biomarker may predict early Alzheimer’s disease
    Erkki Ruoslahti, MD, PhD, has discovered a new approach to detect Alzheimer’s disease at its earliest stages. His research team found a biological marker, or biomarker, that’s associated with brain inflammation—a trigger for the Alzheimer’s process, which takes many years to produce symptoms. 
     
  4.  Steps toward a promising therapy for a rare bone disease
    Yu Yamaguchi, MD, PhD, led a study proving fresh insight into the mechanism of multiple hereditary exotoses (MHE)—a rare disease that causes the growth of multiple benign bone tumors. The research opened the door for testing the drug palovarotene in Phase 2/3 clinical trials for patients with MHE.
     
  5. New insights into bipolar disease
    An international collaborative study led by Evan Snyder, MD, PhD, was first to explain the molecular basis of bipolar disease and may support the development of a diagnostic test for the disorder. The research may also help scientists develop tools to predict the likelihood of patient response to lithium treatmenta highly effective drug that works in only 30% of bipolar patients.

Institute News

Preuss School interns get an “A” grade at SBP

AuthorHelen I. Hwang
Date

August 4, 2017

“I got to do things I never thought I could do,” said Yadira Gomez Rangel, 16, a rising junior at Preuss School in San Diego. “I got a chance to dissect a fly, which I didn’t think I could do,” she told the audience at Sanford Burnham Prebys Medical Discovery Institute (SBP), which included SBP Trustees Malin Burnham and Wain Fishburn as well as CEO Perry Nisen, MD, PhD

Rangel is one of seven students from the prestigious Preuss School, who completed a two-week internship. Students from the Preuss School, affiliated with UC San Diego, strive to become the first in their families to graduate from college. The SBP Preuss program is designed to introduce young scientists-in-training to medical research by working hand in hand with our scientists.

The group of 16-year-olds got a chance to rotate among four different labs at SBP. The other students included Michelle Villa Bardales, Josué Barragán, Edizandro Morales Herrera, Arturo Torres Jimenez, Jenny Nguyen and Natalie Nguyen. Students presented posters in English and Spanish, received a certificate and a stipend for their hard work.

Fishburn said the Preuss program at SBP was “inspirational” as he hoped the young teens would continue their path in science. At the celebratory luncheon with students, their families and SBP staff, Fishburn chatted with Tommy Le, a Preuss School graduate. Le was part of the SBP Preuss program for the two-week internship, followed by a six-week internship the following year, and is now doing a summer internship at SBP before entering UC San Diego in the fall where he’ll major in biochemistry.

Each summer, SBP also hosts a six-week internship for rising Preuss seniors, sponsored by the NIH CURE program. Two of the seven interns (who happen to be all female), Gizelle Avitia Mejica and Julieta Morales Ornelas, also completed the two-week Preuss program, which inspired them to apply again at SBP. “About 90 percent of what I learned in the lab I wouldn’t have been taught in the classroom,” says Mejica.  

During the internship, the teenagers studied several aspects of medical research. They examined the correlation between obesity and heart disease in fruit flies in the laboratory of Rolf Bodmer, Ph.D. Also, the kids studied zebrafish and tackled the challenge of curing diabetes in the laboratory of Duc Dong, Ph.D. They looked at how to use C. elegans worms to understand the aging process in the laboratory of Malene Hansen, Ph.D. Finally, in the laboratory of Jing Crystal Zhou, Ph.D., the young scientists learned about RNA modification, a process that occurs in all living organisms and can influence how diseases occur.

With hands-on training and in-depth laboratory involvement, the Preuss students gained invaluable skills and networking opportunities. The program is made possible by founding philanthropists Peggy and Peter Preuss and Debby and Wain Fishburn. Jimenez said, “It’s been a wonderful experience!”

Preuss School Internship Program with SBP Trustees

 

Institute News

Former SBP postdoc Louis Lapierre now assistant professor at Brown University

Authorjmoore
Date

April 15, 2016

This is the first post in a series that will share what past SBP postdocs are doing now. 

Louis Lapierre, PhD, was a postdoctoral researcher in the laboratory of Malene Hansen, PhD, associate professor in the Development, Aging, and Regeneration Program from 2008 to 2014, where he studied the molecular mechanisms of aging using the microscopic roundworm C. elegans. Since January 2015, he has been an assistant professor in the Department of Molecular Biology, Cell Biology, and Biochemistry at Brown University. His lab researches the role of lipophagy in aging, the process by which cells recycle fats to enhance longevity.

What did you gain from your postdoc experience at Sanford-Burnham? What was the best thing about doing science here?

Conducting research at Sanford-Burnham was a great stepping-stone in my career development. After my first publication there, because I was in a lab led by an emerging scientist, I had the flexibility to carry out research that I personally cared about, which led to interesting and unexpected findings. Eventually, I obtained independent financial support that was critical for my transition to independence. Importantly, SBP’s location in La Jolla means that it is surrounded by highly skilled researchers and state-of-the-art infrastructure, which makes for a cutting-edge, competitive environment.

How did you find your first job after your postdoc? Was it challenging?

I interviewed for several positions during the first half of 2014. The faculty job search is grueling, but I feel privileged to have gone through it. The main challenge is the outstanding level of competition not only at research-intensive institutions, but also at lower tier schools.

Why do you say participating in the faculty selection process was a privilege?

I think it’s easy to forget that our accomplishments were possible because, at some point, someone believed in us. Receiving support from colleagues and mentors and then being selected for interview by a search committee is a privilege that only a few postdocs get to experience.

What advice do you have for postdocs who hope to find a faculty position?

During your postdoc, plan meticulously to position yourself in line with funding opportunities and aggressively pursue emerging topics. During the job search, understand your value on the market, develop an interesting research program with long-term potential and strategically market yourself at conferences. 

What do you enjoy most about your work and why?

I think the most fascinating part of basic research is the possibility of making new and exciting discoveries, and being at the forefront of knowledge. I also find mentoring highly rewarding because I get to make a difference in someone else’s life by building their confidence. This is especially gratifying when I get to work with students who have a passion for science, which is so important to thrive in this competitive environment.

What do you miss most about San Diego and why?

You only realize what you have when you lose it. Leaving San Diego was difficult because I knew nowhere else would be as good. I miss San Diego, not only for its incredible weather and beautiful beaches, but most importantly for the great friends I made there.

Institute News

SBP helps students “worm” up to science at STEM Expo

Authorsgammon
Date

March 7, 2016

On Saturday, March 5, a keen group of SBP volunteers hauled wagons of lab coats, mutant worms and magnifying glasses to give the next generation of scientists—mainly kids in grades K-8—an opportunity to see first-hand how tiny worms named C. elegans are used to understand the aging process.

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Institute News

Fine-tuning cellular energy increases longevity

AuthorJessica Moore
Date

February 25, 2016

New research from SBP has identified a protein that can extend the natural lifespan of C. elegans, a microscopic roundworm commonly used for research on aging and longevity. The findings, published in Cell Reports, expand what we know about the aging process and may lead to new ways to delay the onset of human age-related diseases such as cancer and neurodegenerative diseases. Continue reading “Fine-tuning cellular energy increases longevity”

Institute News

SBP’s 37th Annual Symposium: Aging and Regeneration

Authorsgammon
Date

November 3, 2015

On Friday, October 30, more 350 people came to SBP’s 37th Annual Symposium to hear leading scientists present their latest research on aging and regeneration.  The presenters, listed here, provided valuable insight into the latest studies on what causes aging, and strategies to repair injuries, prolong life, and prevent diseases.  The event was hosted by (from left to right): Rolf Bodmer, PhD, Malene Hansen, PhD, (in bee costume for Halloween) Alexey Terskikh, PhD

 

organizers-symposium-beaker

Many congratulations to Esther Minotti for successfully organizing the event!

symposium-photo-beaker

And many thanks to the Glenn Foundation for Medical Research for their support.

Institute News

Newly discovered cell stress pathway could hold therapeutic promise for diverse diseases

AuthorGuest Blogger
Date

January 5, 2015

This post was written by Janelle Weaver, PhD, a freelance writer.

When cells are faced with unfavorable environmental conditions, such as limited nutrient availability, the activation of adaptive stress responses can help protect them against damage or death. For example, stressed cells can maintain sufficient energy levels for survival by degrading and recycling unnecessary or dysfunctional cellular components. This survival mechanism, known as autophagy (literally, ‘self-digestion’), also plays key roles in a variety of biological processes such as development and aging, and is often perturbed in various diseases. Even though tight control of autophagy is key to survival, relatively little is known about the signaling molecules that regulate this essential process. Continue reading “Newly discovered cell stress pathway could hold therapeutic promise for diverse diseases”

Institute News

Sanford-Burnham researcher awarded American Federation for Aging Research award

Authorsgammon
Date

December 23, 2014

Malene Hansen, PhD, associate professor in our Development, Aging, and Regeneration Program has been awarded the Julie Martin Mid-Career Award in Aging Research. The award includes a new grant to continue her research in the field of aging. Hansen is a three-time American Federation for Aging Research (AFAR) grant recipient. AFAR’s grants are given to scientists at institutions nationwide based on hard work, ingenuity, and leadership that advance cutting-edge research to help us live healthier, longer lives. Continue reading “Sanford-Burnham researcher awarded American Federation for Aging Research award”