Nicholas Cosford, Ph.D.

Nicholas Cosford's Research Focus

Related Diseases > Bone Mineralization Disorders, Cancer, Neurodegenerative and Neuromuscular Diseases, Neurological and Psychiatric Disorders, Alzheimer's Disease, Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease), Prostate Cancer, Pancreatic Cancer, Breast Cancer, Ovarian Cancer

We are interested in investigating the interactions of small molecule compounds with therapeutically important proteins and cellular signaling pathways. One aspect of our research emphasizes the use of medicinal chemistry and chemical biology approaches to probe intracellular pathways that regulate cell survival and cell growth. Another area of active research is the development of synthetic chemistry methodology using microfluidic technology for the rapid synthesis of biologically active small molecules. Therapeutically, we are primarily focused on the discovery and optimization of compounds that have the potential to treat cancer, CNS diseases and infectious diseases.

Nicholas Cosford's Bio

Dr. Cosford obtained his B.A. in chemistry and Ph.D. in organic chemistry from the University of Bath in England. As a medicinal chemist with over 20 years of experience leading small-molecule drug discovery and hit-to-lead optimization projects, he worked in both biotech and big pharma prior to joining SBP in 2008.

At Sibia Neurosciences and at Merck Research Laboratories, he directed multidisciplinary research teams focused on small-molecule hit-to-lead optimization and was responsible for moving several lead compounds through to the clinical phase. Examples include taking a nicotinic receptor agonist from initiation of research through to Phase II clinical; taking mGlu5 negative allosteric modulators (NAMs) from HTS hits through in vivo proof-of-concept to Phase I/II (ongoing); design, synthesis and optimization of an mGlu5 PET tracer clinical candidate; and design, synthesis and optimization of an Akt allosteric inhibitor preclinical candidate that led to MK2206. To date, Dr. Cosford’s research has resulted in more than 90 peer-reviewed scientific publications, over 40 issued patents, and over 40 additional patent applications pending.

In 2006, he received the FRAXA Foundation Award for Outstanding Contributions to Fragile X Research. His ongoing industry alliances include serving as a scientific advisor to CalAsia Pharmaceuticals, which seeks to accelerate academic discoveries into treatments for unmet medical needs, and to TumorGen MDx, where he has helped design a microchip to detect the presence of cancer stem cells.

CMSN Accessory

Publications

Egan DF, Chun MG, Vamos M, Zou H, Rong J, Miller CJ, Lou HJ, Raveendra-Panickar D, Yang CC, Sheffler DJ, Teriete P, Asara JM, Turk BE, Cosford ND, Shaw RJ
Mol Cell 2015 Jul 16;59(2):285-97
Welsh K, Milutinovic S, Ardecky RJ, Gonzalez-Lopez M, Ganji SR, Teriete P, Finlay D, Riedl S, Matsuzawa S, Pinilla C, Houghten R, Vuori K, Reed JC, Cosford ND
PLoS One 2016;11(9):e0161952
Dhanya RP, Sheffler DJ, Dahl R, Davis M, Lee PS, Yang L, Nickols HH, Cho HP, Smith LH, D'Souza MS, Conn PJ, Der-Avakian A, Markou A, Cosford ND
J Med Chem 2014 May 22;57(10):4154-72
Pinkerton AB, Sergienko E, Bravo Y, Dahl R, Ma CT, Sun Q, Jackson MR, Cosford NDP, Millán JL
Bioorg Med Chem Lett 2018 Jan 1;28(1):31-34
Zhang X, Kumata K, Yamasaki T, Cheng R, Hatori A, Ma L, Zhang Y, Xie L, Wang L, Kang HJ, Sheffler DJ, Cosford NDP, Zhang MR, Liang SH
ACS Chem Neurosci 2017 Sep 20;8(9):1937-1948
Finlay D, Teriete P, Vamos M, Cosford NDP, Vuori K
F1000Res 2017;6:587