About us

Learn how Sanford Burnham Prebys' innovative research leads to medical discoveries and drug therapies that benefit patients.
scientists at work

Leading the way

Sanford Burnham Prebys Medical Discovery Institute has deep expertise in fundamental biology and one of the most comprehensive drug discovery centers in the nonprofit world that accelerates the translation of our discoveries toward patient benefit.

40+ years

of pioneering research

Our mission

We conduct world-class collaborative research dedicated to finding cures for human disease, improving quality of life, and educating and training the next-generation of scientists, thus creating a legacy for its employees, partners, donors and community.

How we aim to improve human health

Sanford Burnham Prebys Medical Discovery Institute is dedicated to discovering the fundamental molecular causes of disease and devising the innovative therapies of tomorrow. The Institute takes a unique, collaborative approach to medical research and has established major research programs in cancer, neurodegeneration, diabetes, and infectious, inflammatory, and childhood diseases. The Institute is especially known for its world-class capabilities in stem cell research and drug discovery technologies.
Sanford Burnham Prebys is a U.S.-based, non-profit public benefit corporation based in San Diego (La Jolla), California.

Who we are

  • Sanford Burnham Prebys discoveries begin with our people – scientists, postdoctoral candidates, graduate students and support staff – who work collaboratively toward understanding the cause of disease and identifying new therapeutic approaches to improve human health.
  • As an independent, nonprofit institution, we focus on conducting biomedical research in cancer, neuroscience, immunolgy and rare children’s diseases.
  • The Institute is home to one of the most comprehensive drug discovery centers in the nonprofit world.
  • Our innovative approach to research underpins our strategic partnerships with the biotech and pharmaceutical industry.
  • We cultivate the next generation of biomedical scientists through our graduate and postdoctoral training programs.
Sanford Burnham Prebys employs more than 700 scientists and staff in San Diego (La Jolla), CA. We are widely recognized for our NCI-designated Cancer Center, the Conrad Prebys Center for Chemical Genomics and the Sanford Children’s Health Research Center.
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Our approach to improving human health is built on three principles

Fundamental research

Our track record of pioneering research spans more than 40 years, and has produced breakthrough discoveries in cancer, neuroscience, immunology and rare children's diseases.

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Translational research

We operate one of the most advanced drug discovery centers in the world that leverages biomedical discoveries to develop prototype drugs.

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Education and training

We are committed to education and training the next generation of scientific leaders to ensure our legacy continues.

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Fact sheet

Sanford Burnham Prebys Fact Sheet

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Publications

From development to aging: the path to cellular senescence.

Sacco A, Belloni L, Latella L

Antioxid Redox Signal 2020 Mar 31 ;

Genetic and pharmacologic modulation of cementogenesis via pyrophosphate regulators.

Chu EY, Vo TD, Chavez MB, Nagasaki A, Mertz EL, Nociti FH, Aitken SF, Kavanagh D, Zimmerman K, Li X, Stabach PR, Braddock DT, Millán JL, Foster BL, Somerman MJ

Bone 2020 Mar 26 ;:115329

Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells.

Galenkamp KMO, Sosicka P, Jung M, Recouvreux MV, Zhang Y, Moldenhauer MR, Brandi G, Freeze HH, Commisso C

Cancer Discov 2020 Mar 21 ;

Experimental concepts for linking the biological activities of antimicrobial peptides to their molecular modes of action.

Malanovic N, Marx L, Blondelle SE, Pabst G, Semeraro EF

Biochim Biophys Acta Biomembr 2020 Mar 12 ;:183275

Difference contact maps: From what to why in the analysis of the conformational flexibility of proteins.

Iyer M, Li Z, Jaroszewski L, Sedova M, Godzik A

PLoS One 2020 ;15(3):e0226702

Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases.

Minina EA, Staal J, Alvarez VE, Berges JA, Berman-Frank I, Beyaert R, Bidle KD, Bornancin F, Casanova M, Cazzulo JJ, Choi CJ, Coll NS, Dixit VM, Dolinar M, Fasel N, Funk C, Gallois P, Gevaert K, Gutierrez-Beltran E, Hailfinger S, Klemenčič M, Koonin EV, Krappmann D, Linusson A, Machado MFM, Madeo F, Megeney LA, Moschou PN, Mottram JC, Nyström T, Osiewacz HD, Overall CM, Pandey KC, Ruland J, Salvesen GS, Shi Y, Smertenko A, Stael S, Ståhlberg J, Suárez MF, Thome M, Tuominen H, Van Breusegem F, van der Hoorn RAL, Vardi A, Zhivotovsky B, Lam E, Bozhkov PV

Mol Cell 2020 Mar 5 ;77(5):927-929

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