Natasha Giusti, Author at Sanford Burnham Prebys
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Women in Science Lecture series showcases public health and nutrition policy leader

AuthorGreg Calhoun
Date

February 23, 2026

The series highlights the groundbreaking work and unique perspectives of women leaders in the biomedical sciences

On February 11, 2026, Sanford Burnham Prebys Medical Discovery Institute hosted the second event in the Women in Science Lecture Series. The occasion opened with a presentation by Cheryl A.M. Anderson, PhD, MPH, MS, professor and dean of the Herbert Wertheim School of Public Health and Human Longevity Science at the University of California San Diego and director of the UCSD Center of Excellence in Health Promotion and Equity.

Anderson introduced attendees to some of the pivotal findings of her mentors studying the effects of nutrition on public health, including the landmark dietary approaches to stop hypertension (DASH) clinical trial. Because of the challenges in achieving significant heart disease prevention benefits outside of the controlled environments used in studies such as the DASH trial, Anderson was determined to explore other approaches.

“I put together this concept that instead of asking the individual to figure it all out from our dietary recommendations, maybe we could figure out how to have a healthy, sustainable food system,” said Anderson.

“I see a sustainable food system as one that maintains our ability to get lots and lots of nutrition and where you meet the current population’s needs without compromising what future generations might also need.”

In addition to discussing her scientific journey, Anderson provided insight into her experience serving with other experts to provide input into two different iterations of the federal government’s Dietary Guidelines for Americans. These guidelines from the Department of Health and Human Services and Department of Agriculture set the standards for food in federally funded programs such as public school and day care lunches as well as the Women, Infants and Children (WIC) special supplemental nutrition program. Anderson shared her experience working collaboratively to provide science-based counsel in an ecosystem that also contains political considerations such as the interests of industries involved in agriculture and food production.

Angela Liou, MD seated left and Cheryl A.M. Anderson, PhD, MPH, MS right

Anderson (at right) opened the event discussing her career journey focused on how to develop a healthy, sustainable food system. The event also featured a fireside chat and audience question-and-answer session with Anderson and Liou.

Lukas Chavez, PhD, MS, associate professor in the Cancer Genome and Epigenetics Program at Sanford Burnham Prebys and scientific director of the Pediatric Neuro-Oncology Molecular Tumor Board at Rady Children’s Institute for Genomic Medicine, then moderated a fireside chat and audience question-and-answer session with Anderson and Angela Liou, MD, physician-scientist and pediatric oncologist with a dual appointment at Rady Children’s Health and the Cancer Genome and Epigenetics Program at Sanford Burnham Prebys. Topics included: how new scientific insights are translated to reduce population-level health risks or guide care for children facing serious illnesses; how new technologies change the way you conduct research and deliver patient care; what can be done to ensure that scientific discoveries can be equitably accessed and lead to better outcomes for all; and what do future clinicians and scientists need in terms of skills, mindset and institutional support to succeed as public health researchers and physician-scientists.

The Women in Science Lecture Series, featuring quarterly events that are free and open to the public, is part of broader efforts at Sanford Burnham Prebys to foster an environment that nurtures the success of individuals from all backgrounds. The series is hosted by the Office of Workforce Engagement & Belonging and highlights the groundbreaking work and unique perspectives of women leaders in the biomedical sciences, while fostering mentorship and collaboration across the Torrey Pines Mesa.

Registration is open for the next event in the series on May 13, 2026.

Institute News

Science in Pictures

AuthorScott LaFee
Date

February 23, 2026

Carcinoma cells via fluorescence microscopy.

Image courtesy of Frederick Keeney, The Wistar Institute, Philadelphia.

Institute News

Science in Pictures

AuthorScott LaFee
Date

February 16, 2026

Mouse brain vasculature, as imaged by light sheet fluorescence microscopy.

Image courtesy of Ali Erturk, Munich, Germany.

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Cell stress response bears good news and bad news for liver cancer

AuthorGreg Calhoun
Date

February 12, 2026

Cell stress response protein implicated in cancer progression, yet it also weakens resistance to immunotherapies

Metabolic disorders such as obesity and type 2 diabetes place extra stress on the liver. Liver cells try to protect themselves from the accompanying surge in dysfunctional proteins by activating factors that help restore an appropriate protein balance.

One of these factors is a protein called activating transcription factor 6 alpha (ATF6α) that was recently shown to drive the onset of liver cancer if left permanently active. In a Nature study published February 4, 2026, an international team of scientists demonstrated that activating ATF6α in mice caused liver disease that progressed to liver cancer.

In data from human liver cancer patients, ATF6α activation was linked with more aggressive tumors, a suppressed immune system surrounding tumors and reduced patient survival.

The researchers also uncovered ways that ATF6α might be used to advance the treatment of liver cancer. Liver cells with ATF6α switched off developed fewer tumors. While high ATF6α activity levels were associated with cancer progression, they also were found to make tumors more susceptible to certain immunotherapies.

These findings suggest the need for future clinical trials to test drugs that directly target ATF6α to treat the disease. Additionally, it might prove advantageous to screen liver cancer patients for ATF6α activity to find those most likely to benefit from existing immunotherapies.

Portrait of Randal J. Kaufman, PhD

Randal Kaufman, PhD, is a professor in the Center for Metabolic and Liver Diseases at Sanford Burnham Prebys and a co-corresponding author of the study. Image credit: Sanford Burnham Prebys.

To learn more, read the German Cancer Research Center press release.


Xin Li, PhD, a postdoctoral fellow at the German Cancer Research Center (DKFZ), shares first authorship of the study with co-corresponding author Cynthia Lebeaupin, PhD, principal scientist at Pfizer and former postdoctoral researcher at Sanford Burnham Prebys Medical Discovery Institute.

The other co-corresponding authors are Dirk Haller, PhD, Technische Universität München; Randal Kaufman, PhD, Sanford Burnham Prebys; and Mathias Heikenwälder, PhD, University of Tübingen and DKFZ.

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How scientists turned plant poisons into medicines

AuthorGreg Calhoun
Date

February 9, 2026

Scientists and science communicators detail how caustic compounds meant to deter eaters of plants were harnessed to treat diabetes

The US Food and Drug Administration approved Metformin for use as a diabetes drug more than 30 years ago. This medicinal compound—prescribed to patients to help control high blood sugar—was discovered in nature through a toxic herb found in a variety of medieval remedies.

Sanford Burnham Prebys scientists Ani Deshpande, PhD, and Pamela Itkin-Ansari, PhDrecently released episode six of the Discovery Dialogues Podcast focused on Metformin and other medications with origins as plant poisons. The podcast features surgeon and writer Ambarish Satwik, MD, as well as endocrinologist David Nathan, MD, and Nir Barzilai, MD, a geneticist and longevity researcher. 

The new episode of the Discovery Dialogues Podcast is available on YouTubeSpotify and Apple Podcasts.

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Science in Pictures

AuthorScott LaFee
Date

February 9, 2026

Stereomicrography of bacterial growth in a petri dish.

Image courtesy of Neil James Egan, PPG Industries, Cleveland, Ohio.

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Science in Pictures

AuthorScott LaFee
Date

February 3, 2026

A human donor central retinal artery was cannulated (intubated) and perfused with Lectin FITC, a specific protein chemically linked to a fluorescent dye. The microvasculature of the optic nerve head area at the center is visible.

Image courtesy of Dong An, Lions Eye Institute, Australia.

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Q & A with Postdoctoral Researcher Ambroise Manceau, PhD, from the Commisso Lab

AuthorCommunications
Date

January 22, 2026

Meet one of our early-career scientists at Sanford Burnham Prebys Medical Discovery Institute: Ambroise Manceau, PhD, a postdoctoral researcher in the lab of Cosimo Commisso, PhD. Manceau studies pancreatic ductal adenocarcinoma — the most common form of pancreatic cancer with only a 13% five-year survival rate.

When and how did you become interested in science?
When I was very young, I was a bit of a nerd when it came to reading reviews of new scientific studies written for kids. Especially anything related to biology.

I lost sight of that interest at some point in my teenage years. I tried going into computer science, but I realized very quickly that it wasn’t a good fit for me. That forced me to do some deeper self-reflection about what I really wanted to do, and that brought me back to biology.

I started studying biology at college, and everything just clicked into place. I really found my way when I went to college.

What brought you to the Commisso lab at Sanford Burnham Prebys?
I have an uncle that I always admired who is a researcher here in California. From talking with him, it sounded like a great place to work and live as a scientist. When I was an undergraduate in France, I decided to do a four-month internship abroad in Los Angeles at the University of Southern California.

I absolutely loved it, and I knew I wanted to return when I could. Because you can finish your graduate school program a bit faster in France, I decided to go back to France to earn my doctorate and then apply for postdoctoral positions in Southern California.

I was looking for labs conducting interesting research in the region, and that is when I found the Commisso lab. It has been a terrific fit for me.

What are the key areas of research you focus on?
My broad focus is on metabolism and organelle biology in pancreatic cancer. My main project looks at macropinocytosis, which is a cellular process that allows cells to gather extra resources from their surrounding environments. Pancreatic cancer cells use this process as an adaptation because they exist in an environment where resources are scarce, and they need to find fuel for their expansion.

I study the contents taken in when pancreatic cancer cells contort their cell surfaces to create pockets called macropinosomes. By analyzing every single protein located on macropinosomes, I found that calcium and zinc transporter proteins present in macropinosomes also are required for macropinocytosis.

These proteins have never been targeted before in pancreatic cancer. By continuing to research them, our long-term goal is to use this strategy to cut the nutrient supply to tumors and see if we can inhibit tumor growth.

Ambroise Edouard Manceau photo collage in lab

What motivates you about your research?
One thing I enjoy is how you adjust your hypothesis based on what you are learning from the experiments. You need to adapt your hypothesis as you gain knowledge, but you don’t always realize it because it can happen one little step at a time.

Then you look at your project a year later, and it is very satisfying to see how much it evolved and how much you changed your mind by following the data.

Also, now that I have attended pancreatic cancer conferences and met with physicians and patients, I have more appreciation for the need to improve upon available therapies.

What do you like about working here?
The people at Sanford Burnham Prebys embrace collaboration. They also are very curious, knowledgeable and kind. With the core facilities, workshops and other opportunities for learning and networking, we have so many resources available to us.

Then add on top of that the location in San Diego, which is a great hub for biomedical research and the biotech industry. And we have the Southern California coast, culture and weather for when we aren’t working.

Have you had an influential mentor?
In addition to my uncle, my thesis mentor and principal investigator back in France were very influential in my professional development. Here, I feel like Cosimo is doing everything he can to get the best out of me, including supporting me to go to workshops and conferences.

What do you enjoy doing when you’re not in the lab?
I’m a bit addicted to rock climbing, and San Diego is a great place to be a climber. I have access to an incredible indoor climbing gym, but I also can go climbing outdoors within a 15-minute drive from where I live.

I also play a bit of tennis, go running and relax at the beach. And I’m painting some, which is something I used to do on rainy days in France. We don’t have many rainy days here, though, so I always want to be outside.

Postdocs at Sanford Burnham Prebys are pushing the boundaries of science every day through curiosity, collaboration, and innovation. This series highlights their unique journeys, what inspires their work, and the impact they’re making across our labs.

Explore the Full Series

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Science in Pictures

AuthorScott LaFee
Date

January 19, 2026

Using confocal, deconvolution and image stacking techniques, a micrograph of a human I pluripotent stem cell-derived cardiac organoid.

Image courtesy of Syed Ashraf, Divya Sridharan and Salvia Zafar, Ohio State University.

Institute News

Science in Pictures

AuthorScott LaFee
Date

January 12, 2026

A confocal micrograph of human neurons reprogrammed from skin cells.

Image courtesy of  Bruno Cisterna and Eric Vitriol, Medical College of Georgia at Augusta University.