ngiusti, Author at Sanford Burnham Prebys
Institute News

Two trainees selected for Science in Motion Travel Awards

AuthorGreg Calhoun
Date

August 29, 2025

The Sanford Burnham Prebys Center for Cardiovascular and Muscular Diseases recently announced the winners of the 2025 Science in Motion Travel Awards.

Gabriele Guarnaccia, a graduate student in the lab of Alessandra Sacco, PhD, will use his award to attend the 8th Cancer Cachexia Conference being held September 25–27, 2025, in Turin, Italy.

Luca Caputo, PhD, a postdoctoral associate in the lab of Pier Lorenzo Puri, MD, was selected to attend Frontiers in Myogenesis: Innovations in Myogenesis, From Molecular Mechanisms to Therapeutic Interventions, which will be held October 6–11, 2025, in Sunriver, Oregon.

The goal of the Science in Motion Travel Awards is to support conference participation for emerging researchers in labs with a primary affiliation in the Center for Cardiovascular and Muscular Diseases.

Applications will open again on January 15, 2026.

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Science in Pictures

AuthorScott LaFee
Date

August 25, 2025

A colorized scanning electron micrograph of mouse fat cells (red) surrounded by a network of blood vessels (green).

Image courtesy of Daniel Malide, National Heart, Lung and Blood Institute, NIH.

Institute News

Q & A with Postdoctoral Researcher Kelly Li, PhD, from the Yip Lab

AuthorCommunications
Date

August 22, 2025

Blending a love of biology with the power of data science, Kelly Li, Phd, is tackling one of life’s biggest mysteries: aging. In Yuk-Lap (Kevin) Yip’s lab at Sanford Burnham Prebys, Kelly studies how aging cells influence disease, teaming up with collaborators to explore promising new therapeutic approaches.

Can you tell us about your research at Sanford Burnham Prebys?
I’m part of a pure computational biology lab, where we analyze complex biological data instead of doing benchwork. My current project focuses on aging and senescence—cells that no longer function but don’t die and can affect surrounding cells through inflammation. We use cutting-edge tools like single-cell multi-omics to study these cells and explore potential therapeutic targets. It’s a highly collaborative effort, especially with Dr. Peter Adams’ lab.

How did you first become interested in science?
I’ve always been curious about how things work, especially complex systems like biology. I studied cell and molecular biology as an undergrad and was fascinated—but also frustrated—by how traditional experiments studied one gene at a time. I wanted a more holistic view, so I turned to computational biology during my Ph.D., where I used data science to study diabetic complications. That’s when I really fell in love with using machine learning and data analysis to understand biology.

What brought you to Sanford Burnham Prebys?
I followed my mentor, Dr. Kevin Yip, here from Hong Kong. He moved during my Ph.D., and we had ongoing projects, so it was a natural transition for me to join his lab as a postdoc. I’ve been here since October 2022 and am now working on this exciting aging-related project.

What’s it like to collaborate on such a large project?
It’s very dynamic. The project involves collaborators across Sanford Burnham Prebys, UC San Diego, and institutions like Yale and the University of Minnesota. We meet regularly, share data and ideas, and refine our hypotheses together. I lead the data analysis side, so after running results, I’ll send them around, and we iterate based on group discussions. These interactions are where new ideas often emerge.

What motivates you about your research?
It’s a combination of curiosity and a desire to make a meaningful impact. Curiosity drives me to ask deeper questions and design more insightful experiments. I also find motivation in the research process itself—troubleshooting challenges encourages critical thinking and fosters collaboration with others.

How has the Institute supported your growth?
The environment is very collaborative. It’s easy to talk science—even informally in the lunchroom—and that leads to meaningful conversations and collaborations. I’ve also benefited from professional development programs like grant writing and leadership workshops. They’ve helped not just with research but with career planning as well.

You received a Fishman Fund Award. What did that support allow you to do?
The Fishman Fund I received is a career development award for postdocs. I used the funding to attend aging-related conferences, which helped me get up to speed in the field. I connected with other researchers, heard inspiring talks, and had great discussions with trainees and leaders in aging research. It really expanded my perspective and helped me refine my research questions.

What are your career goals?
I’d love to stay in academia and eventually run my own lab. Whether that’s in the U.S. or back in Hong Kong, I’m not sure yet. But I’m committed to research and continuing to explore how computational approaches can answer big biological questions.

Kelly Li photo collage

What do you enjoy outside of science?
I like hiking and exploring the beautiful nature around San Diego. I also enjoy watching movies, dancing, and going to the gym—I try to stay active. That’s part of the anti-aging routine, right?

Do you have any advice for aspiring scientists—especially those interested in computational biology?
Yes! Learn the basics—both programming and biology. You need to understand the data and the underlying biology to really make discoveries. Stay curious and motivated, even when you’re knee-deep in code. And be collaborative—great ideas often come from conversations with others.

Any mentors who’ve had a big impact on your journey?
Definitely my PI, Kevin Yip. He’s been my mentor since undergrad. He introduced me to computational biology, was incredibly patient when I was just starting out, and has always supported me. I learned so much from how he approaches writing, research, and mentoring. I’m very grateful.

Postdocs at Sanford Burnham Prebys are pushing the boundaries of science every day through curiosity, collaboration, and innovation. This series highlights their unique journeys, what inspires their work, and the impact they’re making across our labs.

Explore the Full Series

Institute News

Science in Pictures

AuthorScott LaFee
Date

August 18, 2025

Hepatocytes or liver cells are the most abundant cell type in the human liver, and play multiple roles, including building proteins, producing bile to aid digestion of fats and chemically processing molecules found normally in the body, like hormones, as well as foreign substances like medicines and alcohol.

Image courtesy of Donna Beer Stolz, University of Pittsburgh.

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Science in Pictures

AuthorScott LaFee
Date

August 11, 2025

A confocal micrograph of Drosophila (fruit fly) ovirioles. In female insects, ovirioles are tubes in which eggs cells form at one end and complete development as they reach the other end of the tube. Scientists use insect ovarioles to study basic processes that help insects, including those that cause disease, reproduce quickly.

Image courtesy of National Institutes of Health.

Institute News

Summer interns SPARK interest in regenerative medicine

AuthorGreg Calhoun
Date

August 7, 2025

Eleven participants presented posters at event marking the end of six weeks of hands-on biomedical research experience at Sanford Burnham Prebys

The institute welcomed its fourth cohort of interns this year for the Summer Program to Accelerate Regenerative Medicine Knowledge (SPARK). SPARK is an initiative by the California Institute for Regenerative Medicine (CIRM) that provides research opportunities for high schoolers from underrepresented groups throughout California.

The SPARK participants completed six-week internships at Sanford Burnham Prebys and completed projects under the supervision of their faculty mentors.

“My internship experience has been terrific,” said Aanika Tipirneni, a rising senior who worked in the lab of Evan Snyder, MD, PhD. “I learned about stem cells a few years ago in school, and I never thought I’d actually have a chance to work with them as a high school student.”

“I was able to do a ton of research and even had my own project, which was a truly rewarding experience,” said Ananya Asudani, a rising senior who interned in the lab of Sanjeev Ranade, PhD, director of the SPARK internship program.

“I met a lot of interesting people from all over the world this summer,” said Daniel Ruiz, who will be attending Loyola University of Chicago this fall after his internship in the lab of Xueqin (Sherine) Sun, PhD. “I also enjoyed learning the sterile procedures for growing cells in culture and how to prepare gels for my experiments.”

SPARK intern presenting poster. Image credit: Sanford Burnham Prebys

Image credit: Sanford Burnham Prebys

The interns delivered poster presentations at an event held on campus on August 1, 2025. The students detailed their projects and what they had learned over the course of their internships.

“These students are amazing,” said Ranade. “They are so motivated already as high school students, and they all will go on to do great things.”

SPARK intern presenting poster. Image credit: Sanford Burnham Prebys

Image credit: Sanford Burnham Prebys

“I think the most important thing I learned this summer was the ability to design and carry out a research project,” said Asudani. “It also was motivating to see how everyone in the lab brings different expertise to the table, and yet they all work together cohesively for the overall goal of studying congenital heart defects in Down Syndrome.”

“I’m hoping to continue working in the Snyder lab throughout the school year while applying to universities with opportunities to continue studying stem cells and regenerative medicine,” said Tipirneni.

The SPARK internship culminated with CIRM’s annual SPARK conference at The Alexandria at Torrey Pines from August 3-4, 2025. The participants from Sanford Burnham Prebys presented their work and networked with more than 110 interns from other institutions across the state.

“I would definitely recommend the SPARK internship to any high school student interested in biology, stem cells and regenerative medicine,” said Ruiz. “It’s such an outstanding opportunity to learn, gain experience and get connected in the field, and it absolutely was a highlight of my summer.”

2025 Sanford Burnham Prebys SPARK interns

Institute News

Preuss School interns wrap up unforgettable research experience

AuthorGreg Calhoun
Date

August 4, 2025

Aspiring biomedical researchers and health care professionals gained hands-on research training during three weeks at Sanford Burnham Prebys

On Friday, July 25, 2025, the Sanford Burnham Prebys community celebrated the contributions of six high school student interns from the Preuss School. Located on the University of California San Diego campus in La Jolla, the Preuss School educates students striving to be first-generation college graduates.

Participants in the Preuss internship program gained valuable hands-on research experience over three weeks. This program is generously funded by Peggy and Peter Preuss, and Debby and Wain Fishburn.

The students were split into teams of three to complete complementary experiments while studying the common fruit fly.

“The interns have learned biological concepts and experimental techniques, and also participated in career development workshops,” said Yuk-Lap (Kevin) Yip, PhD, a professor and the interim director of the Center for Data Sciences at Sanford Burnham Prebys, during the July 25 capstone presentation.

“Over the course of just three weeks, they have learned about how an unhealthy diet will affect the health of fruit flies.”

The interns discussed what attracted them to the program and presented the results of their experiments.

“I chose this program because I wanted to learn more about biology and the biomedical research field,” said intern Ahmed Ahmed.

Preuss Interns conducting experiment using fruit flies, pipetting in the lab

Image credit: Sanford Burnahm Prebys.

“I want to become a forensic scientist,” said intern Mia Gidey. “I know I need to have hands-on lab experience, so this program was really beneficial for me.” 

“This program has helped me develop a better understanding of what I would like to pursue as a career,” said intern Joshua Hernandez.

In addition to studying the effects of high-fat and high-sugar diets on fruit flies, the participant teams also had the opportunity to learn additional research techniques during workshops.

Preuss Interns conducting experiment using fruit flies, pipetting in the lab

Image credit: Sanford Burnahm Prebys.

“We were able to conduct flow cytometry experiments with our mentor, Theo Tzaridis,” said intern Bella Dinh. Flow cytometry is a technology that analyzes single cells or particles as they flow past one or more lasers while suspended in a fluid. The interns used the technique to examine proteins on the surfaces of cancer cells that affect the activity of immune cells and the effectiveness of immunotherapy.

“Our group took part in an STK4 inhibitor screening workshop with our mentor, Josh Minyard,” said intern Daniela Ledesma. The participants learned about the drug discovery and development process and went hands-on to compare the efficiency and potency of three drug candidates.

“Thank you so much to everybody that helped us throughout this journey,” said intern Kenia Avila. “We appreciate all of you and we are so grateful for everything that you’ve done.”

Katya Marchetti, a graduate student at Sanford Burnham Prebys and coordinator of the 2025 Pruess internship program, provided closing remarks following the interns’ capstone presentations.

“I am just completely blown away by how incredible every single one of you are,” said Marchetti. “Beyond the techniques and protocols you learned, I hope that you walk away from this summer with a better idea of what you might want to pursue as a career as well as the ability to think like a scientist.”

Institute News

Science in Pictures

AuthorScott LaFee
Date

August 4, 2025

The face of a 6-day-old zebrafish larva, one of science’s preferred animal models. What look like eyes will develop into nostrils and the bulges on either side will become eyes.

Image courtesy of Oscar Ruiz and George Eisenhoffer, University of Texas MD Anderson Cancer Center.

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Science in Pictures

AuthorScott LaFee
Date

July 28, 2025

Micrograph of mouse keratinocytes, a major cell type of the epidermis or outermost layer of skin.

Image courtesy of Nancy Kedersha, ImmunoGen, Inc.

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Opinion: How long are we going to live? The question should be: How well?

AuthorDavid A. Brenner
Date

July 24, 2025

It’s not hard to estimate life expectancy. Online calculators abound, from very simple to more complex, from the ominous (Death Clock) to the optimistic (Living to 100).

The information they require for predictions range from minimal, such as gender and age (Social Security), to fairly detailed. The Living to 100 calculator, for example, asks dozens of questions about diet, sleep habits, stress factors and incorporates data from the on-going The New England Centenarian Study at Boston University.

It’s hard to estimate life expectancy.

While these calculators are fun (barring unhappy results) and sometimes informative, they are guesstimates. However, scientists are developing tools that more precisely predict life expectancy based upon empirical indicators, such as mutation rates, blood biomarkers, telomere length and DNA methylation patterns that measure how your body is aging at a cellular level.

I am a principal investigator in the CIAO Study, an international effort to divine the longevity secrets of centenarians living in the Cilento-Salerno region of Italy. Some of the factors that help them live long and well are plainly apparent: They have active, social lives. They eat right, i.e., the Mediterranean diet. They are mentally resilient.

But these centenarians also have lower blood levels of metabolites (substances produced or used during metabolism) linked to cardiovascular disease and diabetes. They enjoy robust microcirculation of blood, comparable to persons 30 years younger, with lower levels of fasting glucose levels and LDL (bad) cholesterol.

Their telomeres are longer. Telomeres are the protective caps at the ends of chromosomes, like the plastic tips of shoelaces. Telomeres naturally shorten with age, and shorter telomeres are associated with an increased risk of cancer, heart disease and other age-related ailments. But telomere shrinkage is not fixed. It can be affected, good and bad, by lifestyle and other factors.

Our goal should be to accurately compare biological age versus chronological age. The latter can be deceiving: Some 60-year-olds are frail and have heart disease while others are pictures of health. A biological age lower than a chronological age suggests healthier aging and a longer life despite what the calendar says.

More and more, there are tests that effectively measure biological age, though none you can do online at the moment.

For example, a new blood test powered by machine learning analyzes hundreds of proteins to estimate a person’s risk of developing 18 major age-related diseases, such as  heart disease, cancer, diabetes and Alzheimer’s, and of dying prematurely from any cause. Other blood-based tests estimate the biological age of individual organs, a potential predictor of future, organ-specific health problems.

Key among these organs is the brain. Imaging technologies are helping researchers measure the rate of age-related cognitive decline and risk of dementia — sometimes with a single MRI scan.

Another approach, notes Xiao Tian, who studies aging processes and mechanisms at Sanford Burnham Prebys, is the frailty index, which combines key elements of a person’s medical history, functional status (like ability to dress or prepare meals) and performance tests, such as gait speed and handgrip strength.

“A higher frailty index suggests that the biological systems in the body are under greater decline or faster aging, regardless of chronological age,” said Tian. “Frailty assessments are now being adapted to middle-aged populations to catch early signs of accelerated aging.”

The body provides plenty of peeks into its biological future, from how it modifies DNA to perform necessary functions and how each of us uniquely converts food and drink into energy to whether we can lift modest weights or walk without immediate fatigue.

This data, combined with important lifestyle factors like marital status, smoking, alcohol consumption and physical activity, can help predict life expectancy more accurately. But the value of these tests isn’t in predicting how old you might become, but rather in helping determine how many of those years are likely to be spent in good health if you do the right things.

And that, after all, is the answer we’re all really seeking.

View the original piece in The San Diego Union-Tribune