Targeting the molecular parts of health and disease
Cancer and human disease are fundamentally molecular. Just like a complex machine is a sum of its mechanical parts, human biology is made up of many molecular parts.
Our goal is to understand how the molecular parts work with each other to support health, and how they malfunction to cause disease. This molecular view of biology guides the way we study disease progression, the methods we use to understand it, and our approach to discovering new therapies.
Members of the CMS program focus on understanding how the many "molecular parts" – proteins, genes, lipids, minerals, vitamins, sugars, and carbohydrates – work together to promote the fundamental processes of cellular life and death, signaling across cell membranes, healthy metabolism, and immunity. We want to know WHAT they do, HOW they work, and WHAT they look like. This approach is central for targeting cancer treatment and discovering new therapies.
Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor.
Huang J, Duran A, Reina-Campos M, Valencia T, Castilla EA, Müller TD, Tschöp MH, Moscat J, Diaz-Meco MT
Cancer Cell 2018 Apr 9 ;33(4):770-784.e6
Ekanayake V, Nisan D, Ryzhov P, Yao Y, Marassi FM
Biophys J 2018 Aug 7 ;115(3):533-542
Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy.
Lundquist MR, Goncalves MD, Loughran RM, Possik E, Vijayaraghavan T, Yang A, Pauli C, Ravi A, Verma A, Yang Z, Johnson JL, Wong JCY, Ma Y, Hwang KS, Weinkove D, Divecha N, Asara JM, Elemento O, Rubin MA, Kimmelman AC, Pause A, Cantley LC, Emerling BM
Mol Cell 2018 May 3 ;70(3):531-544.e9