diversity Archives - Page 2 of 2 - Sanford Burnham Prebys
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Back by popular demand: The Rising Stars Symposium at Sanford Burnham Prebys

AuthorMiles Martin
Date

May 17, 2023

The annual event aims to foster greater diversity in biomedical research and shine a spotlight on the next generation of scientific leaders.

Sanford Burnham Prebys recently hosted its second annual Rising Stars Symposium, an event that showcases the biomedical research of exceptional postdoctoral and junior faculty candidates from across the country.

Laura Menocal“This was such a valuable learning experience for me,” says Rising Star Laura Menocal, currently a PhD candidate at Weill Cornell Graduate School of Biomedical Sciences. “Participating in the Rising Stars Symposium gave me an important opportunity not only to share my own scientific accomplishments, but also to network and connect with other scientists who share the same passions at an institution that actively fosters inclusivity.”

The 12 Rising Stars were invited, all expenses paid, to the Institute to present their research, network and learn more about postdoctoral and junior faculty opportunities there. 

“This year’s Stars shone bright with their promise and dedication to science,” says Angelica Rocha, PhD, diversity officer, head of the DEI Council at Sanford Burnham Prebys and one of the key organizers of the Symposium. “Their work could lead to the scientific breakthroughs that change the way we view and treat disease. They are at a pivotal stage in their careers, and we would be thrilled if they made our Institute their new home.” 

The event was hosted by the NCI-designated Cancer Center’s Diversity, Equity and Inclusion (DEI) Team and the Institute’s DEI Recruiting Committee, who strive to create an inclusive workforce through equitable hiring, recruitment, and retention practices. 

“Many organizations use diversity and inclusion as buzzwords without taking any concrete steps to actually create inclusive systems and environments,” says Menocal. “Sanford Burnham Prebys is breaking this mold by hosting the Rising Stars Symposium, and I am so proud to have been able to participate.”

After a brief introduction from President and CEO David Brenner, MD, UC San Diego professor JoAnn Trejo, PhD, opened the day of presentations with a keynote address discussing her research on cellular signaling and her experience as a first-generation college student. She also spoke about her years of experience promoting diversity in the biomedical scientists and mentoring early-career scientists.

“I didn’t grow up in a family of scientists. I actually grew up in a family of migrant farmworkers,” said Trejo during her talk. “I had no immediate role models and no one to guide me into what I was going to do. It was mentors who helped me get there—crossing paths with the right people, making connections, and getting good advice and guidance.”

In addition to presenting their work, the Stars were the guests of honor at an afternoon reception celebrating diversity in science. They also participated in professional development workshops, toured the laboratories and core facilities of the Institute, and met with faculty to learn more about career opportunities.

Institute News

Presenting The Conrad Prebys Foundation fellows

AuthorMiles Martin
Date

May 15, 2023

Thanks to a generous grant from The Conrad Prebys Foundation, a diverse group of early-career researchers will gain hands-on experience in drug discovery and translational medicine.

A new educational program at Sanford Burnham Prebys has welcomed a diverse group of early-career scientists to learn how to transform research discoveries into treatments for human diseases. The program was made possible by a generous grant from The Conrad Prebys Foundation as part of its mission to increase the diversity of San Diego’s biomedical workforce.

“Our mission at The Conrad Prebys Foundation is to create an inclusive, equitable and dynamic future for all San Diegans,” says Grant Oliphant, CEO at The Conrad Prebys Foundation. “San Diego is one of the top areas in the country for biomedical research, and we’re pleased to partner with Sanford Burnham Prebys to help strengthen the pipeline of diverse talent in life sciences research.”

Graduate students and postdoctoral fellows selected for the program will complete projects at the Institute’s Conrad Prebys Center for Chemical Genomics (Prebys Center), the nation’s leading nonprofit drug discovery center. The Prebys Center specializes in finding new medicines for diseases with a substantial unmet medical need in order to develop better therapies. 

“Thank you to The Conrad Prebys Foundation. I am beyond grateful for their support,” says predoctoral Prebys fellow Michael Alcaraz, who will complete his project on the links between aging and brain disease with Professor Peter D. Adams, PhD, and Steven Olson, PhD, executive director of Medicinal Chemistry at the Prebys Center. 

To help fulfill the Foundation’s mission, Sanford Burnham Prebys students and postdocs from historically underrepresented groups were encouraged to apply for the new program.

“Promoting diversity in the biomedical workforce is a founding principle of our educational program,” says Alessandra Sacco, PhD, vice dean and associate dean of Student Affairs in the Graduate School of Biomedical Sciences at Sanford Burnham Prebys. Sacco will oversee the new program alongside Dean Guy Salvesen, PhD, and Professor Michael Jackson, PhD

“Working actively to train people from all backgrounds gives opportunities to people who may not otherwise have had them—and it also improves the quality of the research itself,” she adds.

“Translational research is one of the biggest priorities in biomedicine right now because it’s how we turn discoveries into actual medicines,” says Sacco. “This program gives students and postdocs an opportunity to build the skills they need for translational research jobs in academia or industry.”

The fellowship will culminate in a final symposium next spring, where the fellows will present their research to their peers and to the wider community. 

“I’m looking forward to gaining more experience and making my contribution to the translational science at the Prebys Center,” says predoctoral Prebys fellow Merve Demir, who will complete a structural biochemistry project with Assistant Professor Jianhua Zhao, PhD, and Eduard Sergienko, PhD, director of Assay Development at the Prebys Center. 

The full list of fellows includes:
 

Postdoctoral Fellows

– Karina Barbosa Guerra [Deshpande Lab, Ed Sergienko co-mentor]
“SGF29 as a novel therapeutic target in AML”
 
– Merve Demir [Zhao Lab, Ed Sergienko co-mentor]
“Structural studies of MtCK and GCDH enzyme drug targets”
 
– Jerry Tyler DeWitt [Haricharan Lab, TC Chung co-mentor]
“Investigating the unique molecular landscape of ER+ breast cancer in black women” 
 
– Alicia Llorente Lope [Emerling Lab, Ian Pass co-mentor]
“Exploring PI5P4Kγ as a novel molecular vulnerability of therapy-resistant breast cancer” 
 
– Van Giau Vo [Huang Lab, TC Chung co-mentor]
“Identifying enhancers of SNX27 to promote neuroprotective pathways in Alzheimer’s disease and Down Syndrome”
 
– Xiuqing Wei [Puri Lab, Anne Bang co-mentor]
“Selective targeting of a pathogenetic IL6-STAT3 feedforward loop activated during denervation and cancer cachexia”

 

Predoctoral Fellows

– Michael Alexander Alcaraz [Adams Lab, Steven Olson co-mentor]
“Activating the NAMPT-NAD+ axis in senescence to target age-associated disease”
 
– Shea Grenier Davis [Commisso Lab, Steven Olson co-mentor]
“Examining PIKfyve as a potential therapeutic target in pancreatic cancer” 
 
– Patrick Hagan [Cosford Lab, Ian Pass co-mentor]
“Discovery and development of novel ATG13 degrading compounds that inhibit autophagy and treat non-small-cell lung cancer”
 
– Texia Loh [Wang Lab, Ed Sergienko co-mentor]
“Investigating the role of HELLS in mediating resistance to PARP Inhibition in small-cell lung cancer”
 
– Michaela Lynott [Colas Lab, TC Chung co-mentor]
“Identification of small molecules inhibiting ATF7IP-SETDB1 interacting complex to improve cardiac reprogramming efficiency”
 
– Tatiana Moreno [Kumsta Lab, Anne Bang co-mentor]
“Identifying TFEB/HLH-30 regulators to modulate autophagy in age-related diseases”
 
– Utkarsha Paithane [Bagchi Lab, TC Chung co-mentor]
“Identification of small-molecule enhancers of Honeybadger, a novel RAS/MAPK inhibitor” 
 

Institute News

How cancer research silos perpetuate inequity in cancer outcomes: An interview with Svasti Haricharan

AuthorMiles Martin
Date

April 18, 2023

The National Institutes of Health recognizes National Minority Health Month each April. This is a time to raise awareness about the importance of reducing the health disparities faced by racial and ethnic minorities.

For our part, we spoke to Assistant Professor Svasti Haricharan, PhD, about her recently published review in Clinical Cancer Research. The paper describes some of the shortfalls of the current research focusing on cancer disparities. It also reveals what needs to happen to solve this problem. 

This paper describes “research silos” in cancer disparities, but what does this term mean?
The cancer research community has made a lot of progress recognizing that cancer research has a data diversity problem. We know that we need more researchers working on cancer disparities—for example, finding explanations as to why some racial and ethnic minorities have worse cancer survival rates than others. We also know that we need to generate more inclusive data in cancer research generally, which means building databases that include data from people of different backgrounds.

However, what we’re talking about in this new paper is a bit more subtle than that. It has more to do with which disparities researchers are studying and how they’re studying them. Cancer-disparities researchers tend to fall into two different categories with two very different approaches. One group focuses more on the societal problems driving disparities, and the other group is looking closely at the biology. But these two paths aren’t intersecting, which is preventing us from truly addressing racial disparities in cancer.

Can you tell us more about those two groups and how this division affects cancer research?
The first group includes researchers who study cancer disparities in the way most people understand them. They focus on social determinants of health, such as socioeconomic status and systemic bias in the healthcare system. The second group looks at the biology directly, focusing on how genetics impacts the molecular biology of cancer. These are both important research areas, and we’ve made a lot of progress independently with each of them.

The problem is that focusing on one or the other ignores something critical that has gained attention in recent years: lifestyle factors have a direct impact on the molecular biology of cancer. Our lived experiences leave a unique footprint in our cells on top of what’s already there because of what we inherited at birth. By keeping these two types of cancer research trapped in silos, we’re missing synergistic leaps that could truly transform our understanding of cancer outcome inequity. Breaking down these silos is the only way to keep moving this type of research forward.

How can we break down these silos? 
Looking at it broadly, funding bodies need to invest more in research that develops datasets using biological samples from underrepresented groups. This will help us learn more about how societal factors can have a different impact on the biology of cancer—depending on the person with the disease. Here in the lab, we need to create experimental systems that better represent the biology of people from racial and ethnic minorities. This could also help us solve an even bigger problem.

Therapeutic strategies for cancer that we find in the lab don’t often make it to the clinic. Improving the diversity of our cancer data will improve this success-to-failure ratio. It will help us identify treatments that work better in some people than in others and choose the best treatments for each patient. In other words, it will help us work toward truly individualized medicine. Ultimately, we can only develop good precision medicine for cancer when we start looking at all patient demographics more equitably.

Institute News

STEM Shadow Day gives diverse students an inside look at Sanford Burnham Prebys

AuthorMiles Martin
Date

December 2, 2022

As part of ongoing efforts to increase the diversity of the Institute’s trainees, Sanford Burnham Prebys’ DEI Education & Training Committee hosted 36 high school and college students from historically underrepresented backgrounds for a day of lab tours and workshops. The event was sponsored by the San Diego MESA alliance, and more than 20 faculty, staff and current trainees came together to help make the event possible. 

“It’s critical for all students to have opportunities to learn more about scientific research at an early phase in their academic career,” says Paula Checchi, PhD, an administrator in the Institute’s Office of Education, Training and International Students and a leader of our Education & Training Diversity, Equity and Inclusion Committee. “Diversity in the lab contributes so much, both to the trainees’ success and to the overall progress of biomedical research. If we’re going to create a more diverse research community, we need to work from the ground up and support young scholars from all backgrounds every step of the way.”

The day began with an introduction by Hudson Freeze, PhD and a keynote address from Alessandra Sacco, PhD, who spoke to the challenges she’s faced as an Italian American and as a woman in science. 

“My parents When I was younger, some of my relatives asked me why I even wanted to study this because the role of women in science was very different then,” Sacco said. “When I started, I was the only woman in the lab, and that made it difficult to integrate. I didn’t think I’d last a week, but day by day you learn to overcome those challenges in front of you, and it gets a little easier, and it becomes an exciting opportunity to grow.”

She also spoke to the importance of diversity in STEM.

“Diversity is a huge resource, especially in scientific research,” Sacco said. “If you’re asking questions nobody has the answer to, and everybody in the room is from the same background with the same mindset, you’re less likely to less likely to find creative answers. Diversity enriches the scientific discussion, and we’re all part of the same research community.”

After the opening comments, high school students attended workshops on networking skills and mentorship. Meanwhile, college students divided into groups and went on guided tours of labs across campus, where they saw firsthand how Sanford Burnham Prebys researchers are solving pressing problems in medicine.

“It’s so exciting that researchers like Dr. Haricharan are looking at breast cancer in Black and brown women and really getting down to the fundamental biology, not just focusing on socioeconomic factors,” says Shadow Day participant Serina Cuza, referring to recent research from the lab of Svasti Haricharan, PhD “I know there could be pushback, but that’s how you know the research is potentially a breakthrough.”

The event ended with a networking lunch followed by a poster session, featuring work by students in the Sanford Burnham Prebys Graduate School of Biomedical Sciences and alumni of this summer’s SPARK internship program.

“I really enjoyed all the people that I met today,” said Shadow Day participant Yaritza Rubio. “I like that there are so many people from so many different parts of the world here.” 

Institute News

New internship program ignites a SPARK

AuthorMiles Martin
Date

August 8, 2022

For the first time, Sanford Burnham Prebys hosted high school interns from the SPARK program, an initiative by the California Institute for Regenerative Medicine (CIRM) that provides biomedical research opportunities for underrepresented groups throughout California. The SPARK interns each completed a six-week project under the supervision of a faculty mentor and presented their results to scientists at the Institute as well as at CIRM’s annual SPARK conference. 

“Our SPARK program selects diverse students from San Diego and Imperial Valley, and we were proud to have these students at Sanford Burnham Prebys as the inaugural class,” says Program Director Paula Checchi, PhD Checchi is an administrator in the Office of Education, Training and International Services at Sanford Burnham Prebys. She developed the educational components of the program and also organized several community outreach events for interns.

Ameera Ali presenting her research

SPARK stands for Summer Program to Accelerate Regenerative Medicine Knowledge, and students worked in labs learning the hands-on techniques that scientists use to study degenerative diseases—with the ultimate goal of finding new approaches to treat the millions of people affected by these conditions.

“I had no idea that people even worked on zebrafish in labs,” said SPARK intern Ameera Ali, who used zebrafish as a model to study heart disease in the lab of Karen Ocorr, PhD “Traditionally in science you only hear about lab mice and lab rats, but zebrafish are so much more interesting. I can’t wait to work with them again.” 

For intern Saranya Anandakumar, who studied in the lab of Victoria Blaho, PhD, the best moment was a simple one. She says, “My favorite part of the internship was getting to see human blood under the microscope! Seeing all the different types of cells was the coolest thing ever.”

Four interns from high schools in Imperial Valley had the added experience of living away from home for the first time. Samantha Alvarez, who completed her internship in the lab of Brooke Emerling, PhD, stayed with a family in the San Diego area.

“I loved it,” says Alvarez. “I got a chance to take a peek at what it’s going to be like in my adult life once I graduate and I’m independent.”

At Sanford Burnham Prebys, the internship program culminated in a final celebration where students had the chance to share the results of their work and what they’ve learned from their time at the Institute. The students then traveled to Northern California August 2–3 for CIRM’s annual SPARK conference, where they presented their work and networked with interns from other Institutions. 

“My biggest takeaway was all the cultural diversity on campus and in the lab,” says Alvarez. “One of my mentors is from Barcelona, and it was so interesting to compare cultures and experiences. Everybody was so nice and welcoming. It was great.”

Institute News

Sanford Burnham Prebys raises flag for Pride Month

AuthorMiles Martin
Date

June 13, 2022

The ceremony featured speakers from the Institute and was the first formal LGTBQ+ Pride event to be held on campus.

Scientists and staff from across the Institute gathered to celebrate LGBTQ+ Pride at Sanford Burnham Prebys by attending a Pride flag raising ceremony. Our employees spoke to the importance of inclusion in STEM, and the Pride flag was hoisted from the main campus flagpole. 

“By supporting LGBTQ+ and other underrepresented groups, institutions signal that they are open to different viewpoints and people, which is crucial,” says Luca Caputo, PhD, a postdoctoral fellow in the lab of Pier Lorenzo Puri, MD Caputo has been heavily involved in the Institute’s DEI initiatives, and he is also a co-founder of the Queer Science Society, an organization that raises awareness on issues facing LGBTQ+ scholars in STEM. 

“Having a celebration such as the Pride flag ceremony here at Sanford Burnham Prebys helps us support LGBTQ+ scientists at the Institute and beyond,” he adds. 

After an introduction by Alessandra Sacco, PhD, Caputo spoke about the importance of Pride Month and highlighted the need to promote inclusion and diversity in STEM. 

“This is just the first step in the right direction of making Sanford Burnham Prebys a truly inclusive campus and Institute,” he said during his remarks. “I and others on campus are going to hold [our Institute] accountable for numerous steps that are necessary to create a real welcoming and supportive environment, not just for queer scholars but for all underrepresented groups.”

In addition to these comments, Caputo shared his personal story as an LGBTQ+ scientist and briefly described the “invisible minority” phenomenon for LGBTQ+ scientists. This term refers to the fact that the LGBTQ+ community is often excluded from studies aimed at understanding diversity in STEM.

“The lack of inclusion in demographics has a profound effect on efforts to increase equity and inclusion for the LGBTQ+ community” says Caputo. “Many undergraduates do not know or have access to a single LGBTQ+ scientist.”

After Luca told his story, Professor Hudson Freeze, PhD spoke to the spirit of inclusion that Sanford Burnham Prebys was founded on. He also mused on the future of inclusion at the Institute.

“This [flag raising] is a good start, but it’s not the end – We have to keep this going,” Freeze said during his remarks. 

And while this was the first formal Pride event to be held at Sanford Burnham Prebys, it certainly will not be the last.

“Pride means freedom. Pride means hope that future generations of LGBTQ+ people won’t have any doubts about themselves and their worthiness to be in STEM,” says Caputo. “Supporting LGBTQ scientist is simply the right thing to do.”

Institute News

Sanford Burnham Prebys hosts inaugural Rising Stars Symposium

AuthorMiles Martin
Date

May 10, 2022

“I had an exceptionally memorable experience,” says Rising Star Myron Keith Gibert Jr., a PhD candidate at the University of Virginia. 

Sanford Burnham Prebys recently hosted the first-ever Rising Stars Symposium, a three-day postdoctoral recruitment event that provided professional development, leadership training, networking opportunities and mentorship sessions for 12 early-career researchers who were selected based on their academic achievements and research scholarship. Faculty and staff were invited to attend a full day of presentations by the Rising Stars.

“It was an honor to host our inaugural Rising Stars!“ says Angelica Rocha, Ph.D , diversity officer at Sanford Burnham Prebys. Rocha adds, “They are emerging scientific leaders from across the country who impressed us with their work and inspired us with their dedication to equity and inclusion. I would be ecstatic if they joined our Institute.”

The event was an institute-wide diversity, equity and inclusion (DEI) initiative hosted by the DEI Recruitment Committee, one of the three subcommittees at the Institute. The Recruitment Committee promotes an inclusive workplace through recruiting strategies that are equitable and result in increased representation for underrepresented groups.

Young male researcher giving presentationAfter a brief introduction from President Kristiina Vuori, MD PhD, Assistant Professor Svasti Haricharan, PhD opened the day of presentations with a keynote address discussing her research on the genetic differences in breast cells of Black women and the consequences for health disparities, as well as the disparities in representation among academic researchers conducting this work.

For example, in 2019, less than 6% of doctorates were earned by Black people, despite making up about 14% of the population. Even fewer progress to faculty positions. Outdoor reception

“Events like the Rising Stars Symposium provide opportunities to capture the leaks in the science training pipeline and continue to provide career development for scientists from diverse backgrounds,” adds Gibert.

In addition to presenting their work, the Stars were the guests of honor at a reception, which also included poster presentations by researchers from Sanford Burnham Prebys. The event concluded with networking and mentorship sessions between each of the Stars and faculty at the Institute, with whom they could potentially conduct research in the future.

“The Symposium opened my eyes to the exciting research taking place at Sanford Burnham Prebys,” says Rising Star Sedelia Dominguez, a PhD candidate at Washington State University. “I gained confidence in myself as a researcher and was able to find a potential place for my next career step.”

Institute News

Implicit bias in the workplace: An interview with Lydia Villa-Komaroff

AuthorMiles Martin
Date

January 26, 2022

When Lydia Villa-Komaroff, PhD, graduated from MIT in 1975, she was one of only three Mexican American women in the United States to ever receive a PhD in a natural science field. Since then, she has had a diverse career, ranging from research benchwork to academic administration, as well as many years working as a biotechnology executive. As a co-founding member of the Society for the Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS), she has also been a longtime champion of diversity in STEM. 

Today, she owns and operates a one-woman consulting firm, where she continues to work with biotech companies and research organizations to help them acknowledge and confront unconscious biases in the workplace.

Ahead of the implicit bias seminar she is delivering to Sanford Burnham Prebys employees on February 7, we sat down with Villa-Komaroff to discuss implicit bias and how it manifests in the sciences, as well as what organizations can do to address it.

How does implicit bias work?
Villa-Komaroff: We make decisions based on the color or gender of a person we see in less time than it takes to blink. Human beings have a way of thinking about others that is influenced by unconscious assumptions. That way of thinking dominates our decision-making, particularly if we are not aware of it. Our society and the structural racism within it are the consequences of those attitudes. 

How does implicit bias manifest in scientific research?
Villa-Komaroff: The most obvious problem is underrepresentation of minority groups. The classic experiment is taking two identical CVs and giving one a man’s name and one a woman’s and sending them in for the same position to see how they’re received. Men are deemed to be more competent, they’re deemed to be more hirable, they’re more likely to get mentoring and they’re offered higher starting salaries. People really believe they’re making decisions based on merit, but in many cases they aren’t. 

Why is it important to address implicit bias in scientific research?
Villa-Komaroff: Most scientists have heard the term implicit bias, but scientists don’t fundamentally believe that they make any decisions based on biases. But they do, because this is something that’s shared by every member of the human race. It’s not unique to white men. My agenda is to convince scientists that this thing called implicit bias is real and it impacts them and their decisions.

What can individuals and institutions do to recognize and prevent implicit bias?
Villa-Komaroff: The first thing is awareness. You have to be aware that this is something you need to watch out for. The second thing is that we need to put in place processes and checks and balances that help people when they’re making decisions. Those are the important things in terms of hiring faculty and recruiting students. There’s also a need for systems to support students and help them understand how structural racism affects them. People need to realize that recruiting and mentoring people of color doesn’t just benefit them, it benefits everybody. 

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Institute News

New CIRM grant to fund research internships for underrepresented high school students

AuthorMiles Martin
Date

January 25, 2022

Thanks to a new grant awarded to Sanford Burnham Prebys by the California Institute for Regenerative Medicine (CIRM), 57 California high school students from underrepresented groups will have the chance to complete a paid internship at the Institute for the next five consecutive summers. The $509,000 grant was awarded to Paula Checchi, PhD, Alessandra Sacco, PhD, and Evan Snyder, MD, PhD

The mission of CIRM is to accelerate stem cell research and provide treatment to patients with unmet medical needs. And although CIRM directly funds faculty, many of their initiatives also focus on training the next generation of stem cell researchers. Late last year, Sanford Burnham Prebys received $5 million from CIRM to fund new training programs aimed at PhD students and postdoctoral researchers.

“One of the benefits of a program like this is that we’ll be able to inspire students early to pursue biomedical research,” says Checchi, a principal investigators on the grant and longtime educator of high school and undergraduate students. “A lot of students might not even realize that pursuing a STEM degree is an option for them, and that’s something we want to change.” 

The new grant was awarded as part of CIRM’s SPARK Training Program, a diversity, equity and inclusion (DEI) initiative that targets high school students without access to summer research internship opportunities due to socioeconomic constraints. This grant is one of 11 awarded by CIRM to research institutions across California.

“At the high school level, a lot of research internships are unpaid, which can alienate a lot of students, especially if they’re also part of a group that isn’t represented well in scientific research to begin with,” says Checchi. “Programs like this help flip that script and will contribute to increased diversity in science over the long term.”

In addition to getting hands-on research experience, interns will also participate in community outreach, patient advocacy and other educational activities under the mentorship of experienced professors.

“The research element is obviously important, but programs like this also help students develop into confident, capable young scientists who are able to inspire those around them,” says Checchi. “We’re trying to plant the seed for these bright young minds to flourish.”