diversity Archives - Sanford Burnham Prebys
Institute News

Demystifying Día de los Muertos at Sanford Burnham Prebys 

AuthorGreg Calhoun
Date

November 8, 2024

The Institute honored the holiday with a special event that connected participants with the tradition’s customs and cuisine.

On Wednesday, November 6, 2024, Chairmen’s Hall on the Sanford Burnham Prebys campus was transformed by the sights, smells and sounds of Día de los Muertos.

As attendees snacked on sweet breads and sipped Mexican hot chocolate and spiced coffee, they were encouraged to learn more about the holiday through a gallery exhibit featuring posters discussing the tradition’s origin and symbolism.

Día de los Muertos is held on November 1 and 2 each year. It provides an opportunity for families and communities to ceremonially welcome back the souls of deceased loved ones for a reunion. Central to the holiday are altars called ofrendas, or “offerings,” that include personal mementos and symbolic items meant to help guide back the souls of family members. Some symbols also highlight the celebration’s focus on enjoying the sweetness of life even while recognizing the inevitability of death.

The Día de los Muertos event at Sanford Burnham Prebys featured an ofrenda that was constructed through community participation. In the weeks prior, attendees were able to attend two arts and crafts sessions to make wooden sugar skulls and decorate picture frames for the ofrenda.

Institute Dia de los Muetos ofrenda
group of employees eating lunch at Institute Dia de los Muetos celebration
Dia de los Muetos Pan de muerto

Images courtesy of Sara Sandoval

In addition to the gallery exhibit and ofrenda, the event included traditional decorations such as colorful papel picado, a traditional Mexican craft made from perforated tissue paper, which was hung like streamers, as well as monarch butterflies that migrate through Mexico during the holiday and represent the returning souls of ancestors. A playlist of traditional Mexican folk music accentuated the crafts and cuisine, which included family recipes shared in a potluck meal.

This event was a continuation of the Holidays Around the World series at Sanford Burnham Prebys. This series is planned by volunteers from labs and departments across campus, the Diversity, Equity, Inclusion and Belonging (DEIB) Council and DEIB program manager, Lauren Mitchell, MS, to bring the Sanford Burnham Prebys community together to learn more about the many cultures represented within the institute’s faculty, staff and trainees.

More information on the holiday can be found on the website for The Mexican Museum in San Francisco.

Images courtesy of Sara Sandoval.

Institute News

Women in Science event at Sanford Burnham Prebys examines how female faculty members navigate research careers

AuthorGreg Calhoun
Date

August 19, 2024

Four panelists at different career stages shared insights and answered audience questions

Sanford Burnham Prebys held a Women in Science event on Monday, August 12, 2024. The session was in Fishman Auditorium on the Institute’s campus and focused on how female faculty members at different career stages have navigated their professional journeys in academia and the life sciences. 

Eric Wang,  PhD, an assistant professor in the Cancer Molecular Therapeutics Program at Sanford Burnham Prebys and co-chair of the Education and Training Diversity, Equity and Inclusion (DEI) Committee, opened the event and introduced the moderator, Shanshan Yin, PhD, a postdoctoral associate working in the lab of Peter D. Adams, PhD, and four panelists from Sanford Burnham Prebys: 

  • Caroline Kumsta, PhD, an assistant professor in the Development, Aging and Regeneration Program and associate dean of Student Affairs of the Graduate School of Biomedical Sciences 
  • Alessandra Sacco, PhD, the director of the Development, Aging and Regeneration Program and dean of the Graduate School of Biomedical Sciences 

Shanshan Yin, PhD, is a postdoctoral associate working in the lab of Peter D. Adams, PhD. She was the panel discussion moderator.

Work and life balance 

Yin asked the panelists to discuss how they balance their work and personal lives, and what strategies they use to restore their energy levels and maintain a positive mindset. 

“I had to learn to manage my schedule, rather than letting it manage me,” said Kumsta. “I’ve gained a greater appreciation for stepping away from problems, and I often find that I come up with new solutions during or after hiking or working out, instead of by just working more and more.” 

“Because I am setting up a new lab, it feels like I am working even more than I did as a postdoctoral fellow,” said Sun. “My persistence, curiosity and interest in the scientific process are the key drivers that are helping me as the lab gets up to speed.” 

Caregiving 

Yin followed this conversation by requesting that the panelists comment on the factors of childcare and family obligations throughout the careers of female faculty members. 

“The childcare system for working parents in the U.S. leaves a lot of room for improvement,” said Bradley. “This has not improved through the course of my career, and it is something we think about a lot within the Postdoctoral Training Advisory Group as we discuss ways to improve the experience of postdoctoral fellows at the institute.” 

Panelist Xueqin (Sherine) Sun, PhD, is an assistant professor in the Cancer Genome and Epigenetics Program.

“It can be hard to feel less productive as a scientist after having kids,” said Sun. “This is something we each have to navigate and there are no easy answers.” 

Audience questions 

Yin welcomed audience members to ask the panelists additional questions. 

Sacco fielded a question about the balancing act of working long hours for short-term gain versus the increased risk of burnout. She said, “For me, this has really happened in phases. Some parts of certain experiments or application cycles require extra effort, and you have to learn when you can pull back and have a more balanced schedule.” 

Kumsta answered a question about unrealistic expectations for postdoctoral fellows. She said, “I encourage every postdoc and principal investigator to have open and honest conversations about expectations for working hours, vacation time and weekend emails, among other topics. That won’t fix everything, but it will prevent a lot of uncertainty and build a foundation for addressing issues.” 

The panelists had noted the strong representation of male scientists and staff members in the audience. Sacco responded to a question about what male scientists could do better to improve the environment for women in the field. She said, “We should all recognize our own biases, minimize their impact when making decisions, and be good listeners to other scientists’ needs.”      

Gender and academic rank 

The event closed with a conversation about gender disparities in academic ranks at research and higher education institutions. The panelists focused on the attrition than can occur after the end of postdoctoral fellowships as a major challenge for retaining women in academic science.  

Kumsta explored some potential solutions that funders and institutions could consider. She said, “An extra year of funding for early-career female scientists and an extra year on the tenure clock may help us retain women and support their promotion from junior faculty positions. We also need to find ways to reward the extra administrative service that many female faculty members are asked to give on faculty committees.” 

Caroline Kumsta, PhD

Panelist Caroline Kumsta, PhD, is an assistant professor in the Development, Aging and Regeneration Program and associate dean of Student Affairs of the Graduate School of Biomedical Sciences.

“I think certain things are getting better, but we need to do even more to retain women in the field,” said Sun. “The National Institutes of Health allowing time and budget for childcare costs in training grants was an important step.” 

“Today’s event reminds us of the importance of speaking up,” said Sacco. “We can articulate and share our vision for a better tomorrow and work together to achieve it.” 

The Women in Science event was hosted by the Education and Training DEI Committee at Sanford Burnham Prebys and supported by the Institute’s Diversity, Equity, Inclusion and Belonging (DEIB) Council and DEIB program manager, Lauren Mitchell.  

Institute News

Pride flag flies proudly at Sanford Burnham Prebys 

AuthorGreg Calhoun
Date

June 11, 2024

The Institute marked Pride month by ceremonially raising the Pride flag and discussing progress toward inclusion in the scientific community 

Sanford Burnham Prebys recognized the beginning of Pride month with a Pride flag-raising event on Friday, June 7, 2024. The gathering included an opportunity for speakers in a variety of roles throughout the Institute to share comments on the meaning of the Pride flag in their lives and careers. 

David Brenner, MD, president, CEO and Donald Bren Chief Executive Chair at Sanford Burnham Prebys, opened the ceremony, saying, “I’m very proud of everyone for working together to make this a welcoming community.” 

Luca Caputo

Luca Caputo, PhD, postdoctoral associate in the lab of Lorenzo Puri, MD, discussed the mission of the Queer Science Society, which was founded to create a safe space for postdoctoral fellows and other scholars in San Diego. He added, “I’m happy to be here in this inclusive environment.” 

Patrick Kearney, PhD, director of medicinal chemistry in the Conrad Prebys Center for Chemical Genomics, added, “After I joined the Institute last year and saw the Pride flag flying for the first time, I was incredibly moved. It was the first time I’d seen this happen in 40 years as a scientist. While it may seem simple, it is far from trivial, and it tells me that things are different here.” 

Luca Caputo, PhD, postdoctoral associate in the lab of Lorenzo Puri, MD, discussed the mission of the Queer Science Society, which was founded to create a safe space for postdoctoral fellows and other scholars in San Diego. He added, “I’m happy to be here in this inclusive environment.” 

Patrick Kearney, PhD, director of medicinal chemistry in the Conrad Prebys Center for Chemical Genomics, added, “After I joined the Institute last year and saw the Pride flag flying for the first time, I was incredibly moved. It was the first time I’d seen this happen in 40 years as a scientist. While it may seem simple, it is far from trivial, and it tells me that things are different here.” 

Allessandra Cecchini

The Pride flag-raising event was planned by the Institute’s Diversity, Equity, Inclusion and Belonging (DEIB) Council. Lauren Mitchell, MS, program manager for DEIB, expressed gratitude for the meaningful contributions of the volunteers and speakers, as well as the many participants that attended and showed support for DEIB at the Institute.

Pride flag raising

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Institute News

The Conrad Prebys Foundation fellows take center stage

AuthorGreg Calhoun
Date

May 20, 2024

Following a year of hands-on training and scientific inquiry supported by a generous grant from the Conrad Prebys Foundation, a diverse group of early-career researchers recently presented their promising progress on translational research projects.

Twelve scientists-in-training at Sanford Burnham Prebys presented research updates at the Conrad Prebys Foundation Fellows Symposium on May 14, 2024, at the Institute’s Fishman Auditorium.

The presentations were the culmination of a yearlong educational program at Sanford Burnham Prebys providing early-career scientists with workshops, mentorship and research experiences focused on how to transform research discoveries into new treatments. The Conrad Prebys Foundation provided critical funding for the program as part of the foundation’s mission to increase the diversity of San Diego’s biomedical workforce.

Conrad Prebys Foundation fellows poster presentations“This truly has been a pioneering program at the Institute,” says Alessandra Sacco, PhD, director of, and professor in, the Development, Aging and Regeneration Program at Sanford Burnham Prebys; and dean of the Institute’s Graduate School of Biomedical Sciences.

The graduate students and postdoctoral fellows selected to participate in the program conducted projects at the Institute’s  Conrad Prebys Center for Chemical Genomics (Prebys Center), the nation’s leading nonprofit drug discovery center. The Prebys Center specializes in finding new medicines for diseases with a substantial unmet medical need.

“Each participant worked with a pair of co-mentors, one in the laboratory and another in the Prebys Center,” adds Sacco. In addition to extensive mentorship, the program included educational sessions about the drug discovery process.

“This program’s multifaceted approach to training and development has been incredibly rewarding,” says Sacco. Before introducing the symposium’s first speaker, Sacco thanked Michael Jackson, PhD, senior vice president of Drug Discovery and Development at the Prebys Center and director of the Institute’s Cancer Molecular Therapeutics Program; Jessica Colomb, associate director of Administration at the Prebys Center; and all the mentors who contributed to the program’s success.

Conrad Prebys Foundation fellows poster presentationsAfter the conclusion of the fellows’ formal presentations, Lauren Mitchell, MS, program manager for Diversity, Equity, Inclusion and Belonging (DEIB) at Sanford Burnham Prebys, moderated a discussion for fellowship awardees regarding how this training program enriched their skillset, benefited their career development and contributed to their overall sense of belonging and community, among other topics.

The symposium ended with a poster session and reception celebrating the Conrad Prebys Foundation, participants, mentors and contributors.

“I would like to express my utmost gratitude to the Conrad Prebys Foundation for this fellowship,” says Xiuqing Wei, PhD, postdoctoral associate in the lab of Lorenzo Puri, MD, director of, and professor in, the Development, Aging and Regeneration Program at Sanford Burnham Prebys.

Wei adds, “It was a wonderful experience working with my co-mentors on an amazing translational research project.” Wei focused on methods for targeting the abnormal regulation of a key proinflammatory cytokine which is associated with muscle waste under the conditions of nerve injuries and cancer.

The Conrad Prebys Foundation fellows who presented at the symposium were:

Postdoctoral Fellows

  • Merve Demir
    Zhao Lab, Ed Sergienko co-mentor
    “Structural studies of MtCK and GCDH enzyme drug targets”
  • Alicia Llorente Lope
    Emerling Lab, Ian Pass co-mentor
    “Exploring PI5P4Kγ as a novel molecular vulnerability of therapy-resistant breast cancer” 
  • Van Giau Vo
    Huang Lab, TC Chung co-mentor
    “Identifying enhancers of SNX27 to promote neuroprotective pathways in Alzheimer’s disease and Down Syndrome”
  • Xiuqing Wei
    Puri Lab, Anne Bang co-mentor
    “Selective targeting of a pathogenetic IL6-STAT3 feedforward loop activated during denervation and cancer cachexia”

Predoctoral Fellows

  • Michael Alexander Alcaraz
    Adams Lab, Steven Olson co-mentor
    “Activating the NAMPT-NAD+ axis in senescence to target age-associated disease”
  •   Shea Grenier Davis
    Commisso Lab, Steven Olson co-mentor
    “Examining PIKfyve as a potential therapeutic target in pancreatic cancer” 
  • Aditi Pedgaonkar
    Deshpande Lab, Ed Sergienko co-mentor
    “SGF29 as a novel therapeutic target in AML” 
  • Patrick Hagan
    Cosford Lab, Ian Pass co-mentor
    “Discovery and development of novel ATG13 degrading compounds that inhibit autophagy and treat non-small-cell lung cancer” 
  • Texia Loh
    Wang Lab, Ed Sergienko co-mentor
    “Investigating the role of HELLS in mediating resistance to PARP Inhibition in small-cell lung cancer” 
  • Michaela Lynott
    Colas Lab, TC Chung co-mentor
    “Identification of small molecules inhibiting ATF7IP-SETDB1 interacting complex to improve cardiac reprogramming efficiency” 
  • Tatiana Moreno
    Kumsta Lab, Anne Bang co-mentor
    “Identifying TFEB/HLH-30 regulators to modulate autophagy in age-related diseases” 
  • Utkarsha Paithane
    Bagchi Lab, TC Chung co-mentor
    “Identification of small-molecule enhancers of Honeybadger, a novel RAS/MAPK inhibitor”
Institute News

Showcasing stellar scientists-in-training: The Rising Stars Symposium at Sanford Burnham Prebys

AuthorGreg Calhoun
Date

May 7, 2024

The annual event brought 12 doctoral-degree candidates and postdoctoral fellows to the Institute to help nurture diversity in research and feature Rising Stars poised to move science forward.

Sanford Burnham Prebys recently hosted its third annual Rising Stars Symposium, a research meeting and networking opportunity for 12 postdoctoral candidates.

Thomas Martinez, PhD, headshot

“If I could do another postdoctoral fellowship, I would do it here,” said David Brenner, MD, president, CEO and Donald Bren Chief Executive Chair at Sanford Burnham Prebys, during his opening remarks. “I hope you feel very welcome here as part of the family.”

Following Brenner’s introductory comments, Ani Deshpande, PhD, associate professor in the Cancer Genome and Epigenetics Program at Sanford Burnham Prebys and associate director of Diversity, Equity and Inclusion in the Institute’s NCI-designated Cancer Center, introduced the symposium’s keynote speaker, Thomas Martínez, PhD, assistant professor of Biological Chemistry and Pharmaceutical Sciences at the University of California, Irvine.

“I have read all the participants’ biographies, and it is clear you all truly are rising stars,” said Martínez. “Every journey in science is unique, but if you find great mentors, adopt an attitude of service and seek to engage with your community, that will carry you a long way.”

The 12 Rising Stars were then invited to give presentations on research they conducted during their graduate school training.

“I was really excited to share my research at Sanford Burnham Prebys,” says Rebecca Mello, a 2024 Rising Star and graduate student at the Scripps Research Skaggs Graduate School of Chemical and Biological Sciences. “It was an amazing opportunity to participate in such a prestigious event.”

Rebecca Mello headshot

In addition to the full-day symposium, the Rising Stars took tours of the Institute, learned about its core facilities and shared research resources, networked with Institute scientists, and gained a better understanding of postdoctoral opportunities at Sanford Burnham Prebys.

“It was really lovely to meet many members of the faculty and staff,” adds Mello. “It seems like a really welcoming community and a well-equipped research institution.”

“When you compare the symposium to a normal recruiting visit where you might go to one lab and some core facilities, this event allows you to have many more interactions and leaves you with a much more complete understanding of the Institute and its collaborative culture,” says Evelyn Sanchez Hernandez, PhD, a 2023 Rising Star who joined Sanford Burnham Prebys as a postdoctoral associate in the Bradley lab and the Cancer Metabolism and Microenvironment Program. Hernandez moderated a session at this year’s event.

The 2024 Rising Star Symposium was sponsored by the NCI-designated Cancer Center and was planned collaboratively by the Institute’s Diversity, Equity, Inclusion and Belonging (DEIB) Council; the Cancer Center’s Diversity, Equity and Inclusion (DEI) team; and planning and selection committees.

The planners are grateful for everyone who contributes to this Institute-wide effort, including workshop facilitators, panelists, the Communications team, the Research Administrative Services team and many volunteers.

“It made me proud to work here seeing the tremendous partnerships in action that make this symposium possible,” says Lauren Mitchell, MS, program manager for DEIB at Sanford Burnham Prebys. “I think we were successful in shaking up the standard recruiting process and opening the eyes of both the Stars and attendees to new potential opportunities.”

Hernandez says, “This event is really important because it helps promote and foster more diversity in the scientific community, which is something I want to contribute to and help make happen throughout my career.”

Institute News

Speaking of International Day of Women and Girls in Science

AuthorScott LaFee
Date

February 7, 2024

Designated by the United Nations, the 9th International Day of Women and Girls in Science is Sunday, February 11, preceded by two days of meetings, presentations and outreach among global leaders, with a focus on women scientific leadership in sustainable development.

The real work, of course, is what happens afterward. Women continue to be underrepresented in the science, technology, engineering and mathematics (STEM) workforce. In 2021, according to the National Center for Science and Engineering Statistics, 65% of STEM jobs in the United States were held by men, 35% by women. Less than 30% of researchers worldwide are women.

These numbers have long held sway, both in academia and industry. There has been progress, to be sure, but it has been slow and uneven, hindered by stereotypes and biases, a dearth of role models, educational differences and opportunities and sheer inertia. The hurdles to equity and equality are deep and ingrained.

Every female scientist has stories about their own efforts and struggles. We asked scientists at Sanford Burnham Prebys to recount some of theirs, the lessons learned and the challenges yet to be overcome.
 

A fighting chance

My personal experience can testify to the importance of appreciation of diversity.

As an international scholar, it was not always easy to navigate an entirely new culture. I remember my first few months in America when going to a restaurant felt like a small adventure. Now I look back to those days with fondness and gratitude because my mentor and colleagues showed me what an inclusive community means to a newcomer.

They encouraged my expression, valued my input and always waited with great patience when I needed a second or two to fetch a perfect word for the moment. It was their kindness that helped me through the initial adjustment period.

Shengjie Feng, PhDAnd then one day, I found the sense of belonging in a roaring ballpark with my lab mates around me, rooting for Giants. I am grateful that I was shown how “diversity” is done because that is exactly how I aspire to build a team in my future lab, a team where uniqueness is not only accepted but even celebrated so everyone can be at ease as themselves and feels free to explore and express no matter where they are from and what they believe.

While it is important to level the playing field for everyone, sometimes it will not suffice for a disadvantaged group until we vigorously advocate for their rights. As a woman scientist, it pains me that I have witnessed over the years so many brilliant young women who had to stop chasing their dreams at one point or another. They let go of their passion and settled for less ambitious career paths for various reasons: lack of mentorship, family responsibilities and even the pressure of conforming to social norms.

I know how hard it is to achieve success in the highly competitive realm of scientific pursuit while managing a functional family because I am too a mother of two young children. Our society asks women to juggle too many balls. It is no wonder that far fewer
women reach the promised land of professorship when roughly equal numbers of students of
both genders started out on this journey.

I consider it rare fortune that I have been blessed with constant guidance from mentors and unwavering support from family. It will be my mission to pass on this blessing to all the women I have the honor to work with in the future. A fighting chance is all they ask, and I will strive to be the helping hand that delivers that chance.

Shengjie Feng, PhD
Assistant Professor
Degenerative Diseases Program
 

Mentors make a difference

Even though gender inequities in STEM are slowly improving, we still have a lot of work to do. Several studies have shown that among early career investigators, women experience a one-to-two delay in getting their first grants funded, publish fewer high-impact papers and get credited and cited less frequently for their work, as compared to men. I believe that creating awareness and building a supportive network of mentors and peers is extremely important to navigate and overcome the challenges we face in science.

Kelly Kersten, PhDI have always been fascinated by the complex mechanisms underlying disease, and specifically cancer. I was the first woman in my family to attend university and to pursue a PhD degree in the biomedical sciences.

With few women in leading academic positions that could serve as a role model, I found it difficult to believe that I could someday be successful as a scientist. Fortunately, over the past years I have had the opportunity to work with some incredible female scientists who helped me along the way.

During my master’s program at Utrecht University, I secured an internship in the laboratory of the late-Professor Zena Werb at University of California San Francisco. She had an incredible track record of mentoring early career researchers and was a big advocate for (young) women in science.

For my graduate training, I joined the lab of Professor Karin de Visser at the Netherlands Cancer Institute in Amsterdam. Karin is an incredibly smart and determined principal investigator who taught me to be resilient and persistent, and the importance of always following the data. The mentorship and support of these remarkable women has been instrumental in the decisions I have made to date in my career, and I am grateful for the opportunity to have trained under them.

We all need some support and encouragement to excel in our scientific journey. It’s never too early to start building your network of mentors, peers and sponsors to support you along the way.

Kelly Kersten, PhD
Assistant Professor
Cancer Metabolism and Microenvironment Program
 

We’re still a minority

Caroline Kumsta, PhDDuring my PhD and postdoctoral training, I have been lucky to have two amazing female scientists as mentors, who made it seem easy to be successful in science. The reality however is that female scientists get less lab space, have a longer path to their first independent research grant and have a more extended review process for their publications than their male peers.

To achieve equitable treatment and full inclusion of women in science, we have to constantly examine and dismantle the barriers that create these disparities. At Sanford Burnham Prebys, we have started to work toward a more welcoming environment for everyone, including women.

The truth is, however, that we’re still a minority here, and we, as women in science, still have to push for fairer policies and to make sure our voices are heard and valued. Personally, I am involved in outreach programs to get young girls excited about science. Seeing their excitement when they learn something new in the lab reminds me why this is so important, and I get excited when I see the next generation of girls who can see themselves as scientists without a second thought.

Caroline Kumsta, PhD
Assistant Professor
Development, Aging and Regeneration Program
 

Note: On February 14, there will be a roundtable discussion on the topic of women and girls in science from 9:30 a.m. to 10:30 a.m. in Fishman Auditorium. Coffee, pastries and fruit will be served. Click here to RSVP.

Institute News

Sanford Burnham Prebys’ Shadow Day supports diversity and inclusion in STEM education

AuthorSusan Gammon
Date

November 20, 2023

Creating an inclusive environment in STEM is crucial for ensuring a broad range of perspectives and ideas, ultimately contributing to the advancement of scientific research and innovation.

This month, Sanford Burnham Prebys’ DEI Education & Training Committee hosted more than 20 high school and college students from historically underrepresented backgrounds for a day of lab tours and workshops. The event was sponsored by the San Diego MESA alliance, and faculty, staff and current trainees came together to help make the event possible.

“The sponsorship by the San Diego MESA Alliance demonstrates the collaborative efforts between organizations to support diversity and inclusion in STEM education,” said Paula Checchi, PhD, administrator in the Institute’s Office of Education, Training and International Students and leader for our DEI Committee. “Such partnerships play a vital role in breaking down barriers and providing resources to underrepresented students to overcome challenges in pursuing careers in science and technology.”

STEM Shadow Day at Sanford Burnham Prebys serves as a model for other institutions seeking to enhance diversity in STEM fields. By actively engaging with students from underrepresented backgrounds and providing them with meaningful experiences, the Institute is contributing to a more inclusive and equitable future in science and research.

After the opening comments from Checci and Alessandra Sacco, Ph.D, Dean of the Graduate School of Biomedical Sciences and Director and Professor of the Development, Aging and Regeneration Program at Sanford Burnham Prebys, high school students attended a workshop on networking skills and mentorship. Meanwhile, college students divided into groups and went on guided tours of labs across campus, where they saw firsthand how researchers are solving pressing problems in medicine.

“I’ve always known that I wanted to go into a biomedical research career,” said Owen Kelly, a high school student at High Tech High in Chula Vista. Kelly “Coming here and seeing how things really are in laboratories is very cool—it makes me even more excited to think about a future in science.”

The event ended with a networking lunch followed by a poster session, featuring work by graduate students and alumni of this summer’s SPARK internship program—a six-week, fully paid internship open to high schoolers from San Diego and Imperial Counties.

“Diversity is a huge resource, especially in scientific research,” Sacco said. “If you’re asking questions nobody has the answer to, and everybody in the room is from the same background with the same mindset, you’re less likely to less likely to find creative answers. Diversity enriches the scientific discussion, and we’re all part of the same research community.”

Institute News

SPARK interns ignite their passion for research at Sanford Burnham Prebys

AuthorMiles Martin
Date

August 2, 2023

The SPARK program aims to train tomorrow’s experts in regenerative medicine.

Sanford Burnham Prebys welcomed its second cohort of SPARK interns this summer. SPARK, which stands for Summer Program to Accelerate Regenerative Medicine Knowledge, is an initiative by the California Institute for Regenerative Medicine (CIRM) to provide research opportunities for high schoolers from underrepresented groups throughout California. The SPARK interns completed a six-week project under the supervision of a faculty mentor and presented their work to scientists at the Institute.

“It was great connecting with everybody in the lab and learning about their background, why they came here, and what they’re trying to learn,” says SPARK intern Katelyn Gelle. “Getting to compare their experiences with mine was really inspiring, because there’s so much to learn from other people who love science.”

Sanford Burnham Prebys is one of 11 institutions throughout California that hosts SPARK interns, and the program was funded by a grant from CIRM. This year’s interns were the second cohort of five to be supported by that grant.

“Last year’s SPARK program was a great success, and we’re so happy to be able to keep up the momentum with another group of bright, talented interns,” says Program Director Paula Checchi, PhD Checchi is an administrator in the Office of Education, Training and International Services at Sanford Burnham Prebys. Paula developed and oversaw the educational components of the internship program.

SPARK students worked in labs learning the hands-on techniques that scientists use to study degenerative diseases—with the goal of finding new approaches to treat the millions of people affected by these conditions. Completing an individual project with a faculty mentor gave interns the chance to experience the real-life ins and outs of research.

“It was really unexpected how much refining and editing it takes to get a result from experiments” says SPARK intern Medha Nandhimandalam. “You don’t cure cancer in a day.”

The internship also included other educational opportunities, such as a tour of the Sanford Consortium for Regenerative Medicine and a Diversity in Science seminar series. The program culminated in a final celebration at the Institute where students had the chance to share the results of their work and what they’ve learned from their time in the lab.

“The lab itself was my favorite part of the experience – not just the academic side but the whole lifestyle and experience of working with the scientists and spending time with them day to day” says SPARK intern Rini Khandelwal.

As a final capstone to the internship experience, the students will travel to Los Angeles August 8–9 for CIRM’s annual SPARK conference, where they presented their work and networked with interns from other Institutions across the state.

Institute News

San Diego Pride is this week. We asked: Why are LGBTQ+ people the “invisible minority” in STEM?

AuthorMiles Martin
Date

June 22, 2023

Conversations around diversity and inclusion are abundant in academic institutions, but one group in particular—the LGBTQ+ community—is frequently left out of those conversations. 

June is LGBT+ Pride month, but San Diego has made it a local tradition to continue the celebration into July, when the city hosts its annual Pride Festival. This year’s San Diego Pride Festival will be held July 15-16. Pride celebrations around the world give people and institutions alike the opportunity to reflect on the unique struggles of the LGBTQ+ community and consider how we can support these individuals to the benefit of all.

Luca Caputo, PhD

To learn more about the struggles of LGBTQ+ people in the scientific community, we spoke to Sanford Burnham Prebys postdoctoral associate Luca Caputo, PhD Caputo is the cofounder of Queer Science Society San Diego, whose mission is to raise awareness of the concerns of queer scholars in STEM. They are a frequent speaker on LGBTQ+ issues in STEM, most recently at the Fleet Science Center in Balboa Park, where they are included in their New Science exhibition. Caputo is also involved in DEI initiatives here at the Institute, where they helped spearhead our first-ever Pride flag raising last year. 

Why is LGBTQ+ considered the “invisible minority” in STEM? 

The reason why the LGBTQ+ community is an invisible minority is not because there are no queer scientists or STEM professionals. Rather, it’s because there’s a huge lack of data about queer representation in the scientific community. This community has historically not asked for this data, so queer people are not represented in reports and statistics about minority representation. This is not just a data problem—it can prevent LGBTQ+ people from feeling like they belong in STEM. 

Have you personally experienced this?

The lack of representation of queer scientists during my earlier studies had me questioning my belonging in STEM and academia, and the lack of data and discourse around these issues only made it worse. I was lucky and privileged to later encounter great mentors who made me feel welcome and appreciated for everything I am, not only for my pipetting skills. However, not everybody is so lucky.

What needs to happen to correct this problem?

Institutions that track demographic data for scientists and STEM students need to be more inclusive in their methods. This is slowly starting to change—one great example is that the National Science Foundation is finally including questions on sexuality, orientation and gender identity in its Survey of Earned Doctorates, but this is just one small step forward. 

There are still major societal problems affecting queer people in academia, such as unfair U.S. immigration laws that don’t acknowledge same-sex partnerships as marriages for visa purposes. These laws keep talent away from the U.S. or pose an unfair economic burden to same-sex couples, as they will need to travel abroad and navigate complex legislation to get married and be recognized. 

In the meantime, what can non-queer allies do to support the LGBTQ+ community in STEM?

One important thing is being responsive and listening to what members of the community have to say. An easy example is to normalize and respect the sharing of pronouns in email signatures and in Zoom meetings. This will help create a welcoming atmosphere and an environment that will allow LGBTQ+ individuals to safely come out and be confident and comfortable. 

On a more institutional level, many steps can be taken to make workplaces more welcoming, such as having all-gender-inclusive restrooms and honoring Pride months with concrete gestures, like holding Pride events. It’s also important not to wait for members of the LGBTQ+ community to ask for these gestures. These are all approaches that can be translated to being allies to any underrepresented group in STEM, not just the LGBTQ+ community.

How does being more inclusive benefit the scientific community as a whole?

It benefits the community in so many ways. For example, the amount of talent in the scientific community will increase exponentially. Having different point of views will increase our ability to find new cures for diseases and solutions to other real-world problems. Additionally, we have an ethical obligation to make the community inclusive and representative of the whole population, because most basic research is paid for by the entire public via taxes and charitable donations. Finally, increasing inclusivity will also improve the relationship between the scientific community and the general population, as marginalized communities will be able to see their needs and perspectives represented.

Institute News

Opinion: Including researchers of diverse backgrounds makes science more accurate and applicable

AuthorAlessandra Sacco, Michael Jackson and Svasti Haricharan
Date

June 14, 2023

America has always been an experiment, an ongoing enterprise to determine how and how well people of different races, cultures and experiences might govern and live together. It’s an experiment that extends to every aspect of our lives. We celebrate our diversity and inclusivity through the food we eat, the languages we speak and the stories we tell.

Unfortunately, universities and other research institutions in the United States often do not have stories to tell about diversity and inclusion. People of color and women who aspire to careers in academic research are frequently discouraged early on from entering the grueling pipeline (which may extend more than a decade) by the lack of opportunities, access and accommodation.

It is no accident that non-White and female scientists are significantly and consistently underrepresented in the ranks of U.S. academic faculty: approximately 30 percent are female, just 6 percent are Black or Hispanic. Despite recent social awareness and movements toward change, the composition of tenure-track or tenured underrepresented faculty of color in the U.S. increased by only 1 percentage point (11 percent to 12 percent) between 2013 and 2019.

There are fundamental reasons why well-intentioned platitudes and policies regarding science and education don’t reflect reality. Neil A. Lewis Jr., a communications professor at Cornell University, wrote in a 2022 essay in Nature Human Behavior that “What counts as ‘good science’ tends to be research approaches that prioritize the experiences of dominant groups, and not approaches developed to prioritize people placed on the margins of society.”

He added, “The topics that count are ones that fit with the ‘master narratives’ in the field, and not the ‘counter narratives’ that sometimes emerge from marginalized groups.”

Many studies have demonstrated that the more diverse a research team is, the more likely its findings are to move fields forward and create new technologies and inventions. Simultaneously, research conducted by scientists who do not belong to dominant groups is more likely to be ignored by the larger research community, resulting in the so-called “diversity-innovation paradox” that slows scientific progress.

Historically, scientific and clinical studies have addressed research and health questions primarily through the prism of White males, overlooking or ignoring potential — or even likely differences — that might be found in women or people of color. As late as 1977, for example, the Food and Drug Administration recommended excluding women of childbearing potential from phase 1 and early phase 2 drug trials.

This is changing. It’s now well-documented that males and females differ in their response to drug treatment. Likewise, among different ethnicities. Inclusion is now law, and new research points to improved representation among communities of color in most clinical trials.

The embrace of science, technology, engineering and mathematics, or STEM, in public education has become a fundamental force for long-term good. The more children of every size, shape and color who are exposed to these disciplines, the more diverse and energized future generations of scientists, engineers and health professionals will be.

However, we are still in the first steps toward making this journey more accessible to marginalized groups. There is no mainstream movement yet in this direction. The ability to break into the upper echelons of academia continues to be constrained not only by race and ethnicity, but by privilege, with first-generation students facing many more barriers than those with at least one parent with a higher education degree. Scientists who are from the LGBTQ community also face significant challenges to finding acceptance for their research and their identity in academia.

A new educational program at Sanford Burnham Prebys, an independent biomedical research institute in La Jolla, attempts to remedy this singular reality. Funded by a grant from The Conrad Prebys Foundation, the institute has welcomed a group of 13 graduate students and postdoctoral fellows from diverse backgrounds and identities, all of whom will be working in labs, gaining hands-on experience in drug discovery and translational medicine from industry-trained researchers.

They come from near and far, having previously studied at places like San Diego State University, University of San Diego, University of Barcelona and Hong Kong University of Science and Technology. Their research interests are diverse: new treatments for breast and pancreatic cancers, how DNA repairs itself, regenerating heart muscle and how the brain protects itself from Alzheimer’s disease.

The goal is to provide these young scientists with advanced research training that will better position them to not just have successful, productive careers, but also become role models and leaders in biomedical research.

The Prebys Foundation fellows, as they are called, represent a small step in the right direction. Similar efforts are needed elsewhere, everywhere, at small and large institutions, laboratories and places where the work of science gets done.

As a nation, we must be committed to planting the seeds of new generations of scientists through programs like STEM. And when they begin to mature, we must provide the water and nutrients to ensure our young scientists bear fruit for a very long time.

Alessandra Sacco, PhD, is vice dean and associate dean of student affairs in the Graduate School of Biomedical Sciences at Sanford Burnham Prebys, and co-director of the fellowship program. Michael Jackson, PhD, is senior vice president for drug discovery and development and co-director in the Conrad Prebys Center for Chemical Genomics, and co-director of the fellowship program. Svasti Haricharan, PhD, is associate director for training and education in the NCI-Designated Cancer Center at Sanford Burnham Prebys. All live in San Diego.

This story originally appeared in San Diego Union-Tribune.