CIRM Archives - Sanford Burnham Prebys
Institute News

SPARK interns ignite their passion for research at Sanford Burnham Prebys

AuthorMiles Martin
Date

August 2, 2023

The SPARK program aims to train tomorrow’s experts in regenerative medicine.

Sanford Burnham Prebys welcomed its second cohort of SPARK interns this summer. SPARK, which stands for Summer Program to Accelerate Regenerative Medicine Knowledge, is an initiative by the California Institute for Regenerative Medicine (CIRM) to provide research opportunities for high schoolers from underrepresented groups throughout California. The SPARK interns completed a six-week project under the supervision of a faculty mentor and presented their work to scientists at the Institute.

“It was great connecting with everybody in the lab and learning about their background, why they came here, and what they’re trying to learn,” says SPARK intern Katelyn Gelle. “Getting to compare their experiences with mine was really inspiring, because there’s so much to learn from other people who love science.”

Sanford Burnham Prebys is one of 11 institutions throughout California that hosts SPARK interns, and the program was funded by a grant from CIRM. This year’s interns were the second cohort of five to be supported by that grant.

“Last year’s SPARK program was a great success, and we’re so happy to be able to keep up the momentum with another group of bright, talented interns,” says Program Director Paula Checchi, PhD Checchi is an administrator in the Office of Education, Training and International Services at Sanford Burnham Prebys. Paula developed and oversaw the educational components of the internship program.

SPARK students worked in labs learning the hands-on techniques that scientists use to study degenerative diseases—with the goal of finding new approaches to treat the millions of people affected by these conditions. Completing an individual project with a faculty mentor gave interns the chance to experience the real-life ins and outs of research.

“It was really unexpected how much refining and editing it takes to get a result from experiments” says SPARK intern Medha Nandhimandalam. “You don’t cure cancer in a day.”

The internship also included other educational opportunities, such as a tour of the Sanford Consortium for Regenerative Medicine and a Diversity in Science seminar series. The program culminated in a final celebration at the Institute where students had the chance to share the results of their work and what they’ve learned from their time in the lab.

“The lab itself was my favorite part of the experience – not just the academic side but the whole lifestyle and experience of working with the scientists and spending time with them day to day” says SPARK intern Rini Khandelwal.

As a final capstone to the internship experience, the students will travel to Los Angeles August 8–9 for CIRM’s annual SPARK conference, where they presented their work and networked with interns from other Institutions across the state.

Institute News

New internship program ignites a SPARK

AuthorMiles Martin
Date

August 8, 2022

For the first time, Sanford Burnham Prebys hosted high school interns from the SPARK program, an initiative by the California Institute for Regenerative Medicine (CIRM) that provides biomedical research opportunities for underrepresented groups throughout California.

The SPARK interns each completed a six-week project under the supervision of a faculty mentor and presented their results to scientists at the Institute as well as at CIRM’s annual SPARK conference. 

“Our SPARK program selects diverse students from San Diego and Imperial Valley, and we were proud to have these students at Sanford Burnham Prebys as the inaugural class,” says Program Director Paula Checchi, PhD Checchi is an administrator in the Office of Education, Training and International Services at Sanford Burnham Prebys. She developed the educational components of the program and also organized several community outreach events for interns.

SPARK stands for Summer Program to Accelerate Regenerative Medicine Knowledge, and students worked in labs learning the hands-on techniques that scientists use to study degenerative diseases—with the ultimate goal of finding new approaches to treat the millions of people affected by these conditions.

“I had no idea that people even worked on zebrafish in labs,” said SPARK intern Ameera Ali, who used zebrafish as a model to study heart disease in the lab of Karen Ocorr, PhD “Traditionally in science you only hear about lab mice and lab rats, but zebrafish are so much more interesting. I can’t wait to work with them again.” 

For intern Saranya Anandakumar, who studied in the lab of Victoria Blaho, PhD, the best moment was a simple one. She says, “My favorite part of the internship was getting to see human blood under the microscope! Seeing all the different types of cells was the coolest thing ever.”

Ameera Ali presenting her research

SPARK intern Ameera Ali presents her research

Four interns from high schools in Imperial Valley had the added experience of living away from home for the first time. Samantha Alvarez, who completed her internship in the lab of Brooke Emerling, PhD, stayed with a family in the San Diego area.

“I loved it,” says Alvarez. “I got a chance to take a peek at what it’s going to be like in my adult life once I graduate and I’m independent.”

At Sanford Burnham Prebys, the internship program culminated in a final celebration where students had the chance to share the results of their work and what they’ve learned from their time at the Institute. The students then traveled to Northern California August 2–3 for CIRM’s annual SPARK conference, where they presented their work and networked with interns from other Institutions. 

“My biggest takeaway was all the cultural diversity on campus and in the lab,” says Alvarez. “One of my mentors is from Barcelona, and it was so interesting to compare cultures and experiences. Everybody was so nice and welcoming. It was great.”

Institute News

New CIRM grant to fund research internships for underrepresented high school students

AuthorMiles Martin
Date

January 25, 2022

Thanks to a new grant awarded to Sanford Burnham Prebys by the California Institute for Regenerative Medicine (CIRM), 57 California high school students from underrepresented groups will have the chance to complete a paid internship at the Institute for the next five consecutive summers.

The $509,000 grant was awarded to Paula Checchi, PhD, Alessandra Sacco, PhD, and Evan Snyder, MD, PhD

The mission of CIRM is to accelerate stem cell research and provide treatment to patients with unmet medical needs. And although CIRM directly funds faculty, many of their initiatives also focus on training the next generation of stem cell researchers. Late last year, Sanford Burnham Prebys received $5 million from CIRM to fund new training programs aimed at PhD students and postdoctoral researchers.

“One of the benefits of a program like this is that we’ll be able to inspire students early to pursue biomedical research,” says Checchi, a principal investigators on the grant and longtime educator of high school and undergraduate students. “A lot of students might not even realize that pursuing a STEM degree is an option for them, and that’s something we want to change.” 

The new grant was awarded as part of CIRM’s SPARK Training Program, a diversity, equity and inclusion (DEI) initiative that targets high school students without access to summer research internship opportunities due to socioeconomic constraints. This grant is one of 11 awarded by CIRM to research institutions across California.

“At the high school level, a lot of research internships are unpaid, which can alienate a lot of students, especially if they’re also part of a group that isn’t represented well in scientific research to begin with,” says Checchi. “Programs like this help flip that script and will contribute to increased diversity in science over the long term.”

In addition to getting hands-on research experience, interns will also participate in community outreach, patient advocacy and other educational activities under the mentorship of experienced professors.

“The research element is obviously important, but programs like this also help students develop into confident, capable young scientists who are able to inspire those around them,” says Checchi. “We’re trying to plant the seed for these bright young minds to flourish.” 

Institute News

It’s a “Great Idea” Dr. Sacco!

AuthorSusan Gammon
Date

May 31, 2017

Alessandra Sacco, PhD, associate professor in the Development, Aging, and Regeneration Program has been awarded a CIRM “Great Idea.” The award was one of six that are part of CIRM’s Discovery Inception Program to provide funding for great ideas that could impact stem cell research but need funding support to test those ideas. 

Sacco’s proposal, “Generation of expandable, self-renewing muscle stem cells for Duchenne Muscular Dystrophy” will test a new method to boost the supply of cells that help build skeletal muscle—a step toward future therapies for this devastating disorder that affects 1:3500 males.

Although the genetic defect responsible for the disease, the lack of a functional dystrophin protein, has been known for years, still no cure is available to patients.

Patients develop paralysis, cardiorespiratory failure, and death in their early 20s.

The progression of the disease is associated with a loss of muscle regenerative potential, as muscle stem cells (MuSC) become functionally exhausted. MuSCs give rise to skeletal muscle cells, and are involved in the normal growth of muscle, as well as regeneration following injury or disease.

“Our goal is to develop a method whereby self-renewing human MuSCs could be expanded in vitro and then used for “disease in a dish” modeling and drug screening as well as transplanted to provide a supply of cells that self-renew long-term.

“CIRM’s support will help our research team gather the data necessary to apply for larger funding opportunities, from CIRM and other institutions, in the future,” says Sacco.

What is CIRM?

CIRM, California’s stem cell institute, was created by the voters of California in 2004 when they passed Proposition 71. The institute funds stem cell research at institutions and companies throughout California with the goal of accelerating treatments to patients with unmet medical needs.

 

Institute News

National Academy of Inventors names two Sanford-Burnham researchers as Charter Fellows

Authorsgammon
Date

December 16, 2014

Two Sanford-Burnham professors have been named Charter Fellows of the National Academy of Inventors (NAI): Erkki Ruoslahti, MD, PhD, distinguished professor and former president of Sanford-Burnham, and Kristiina Vuori, MD, Ph.D., current president of the Institute. Ruoslahti and Vuori are now part of a group of 414 NAI Fellows from more than 150 prestigious research universities, government, and nonprofit research institutions. Continue reading “National Academy of Inventors names two Sanford-Burnham researchers as Charter Fellows”