Heart Disease Archives - Sanford Burnham Prebys

Tag: Heart Disease

Institute News

A year-end note from David Brenner

AuthorDavid Brenner
Date

December 19, 2023

David A Brenner, MD

This past year — my first full calendar year as president and CEO of Sanford Burnham Prebys — has been exciting and immensely rewarding. We’ve accomplished a lot and, more importantly, laid the groundwork for a wealth of future achievements.

It begins with having a plan. We are in the midst of a biomedical revolution, one in which the old ways of thinking about and doing science no longer address the complexities of modern research or the greater needs in public health.

Sanford Burnham Prebys is particularly positioned to adapt and lead in this new world by combining distinct and powerful resources with a unified mission driven by ambitious goals that emphasize disease-focused centers combined with enabling technology programs.

Of course, doing so requires a brilliant faculty, one that boasts exceptional skills and vision not just in this moment, but in the years to come. Our faculty know what to do. Our newest faculty promise to further propel and elevate. In less than a year, we have hired eight early-career scientists and physicians, an unprecedented number in such a short time.

They are among the best and brightest, coming from elite labs and institutions across the country: Shengie Feng, PhD (Howard Hughes Medical Institute and UCSF); Kelly Kersten, PhD (UCSF); Angela Liou, MD (Children’s Hospital of Philadelphia) Sanjeev Ranade, PhD (Gladstone Institutes); Sanju Sinha, PhD (National Cancer Institute); Xueqin Sherine Sun, PhD (Cold Spring Harbor Laboratory); Kevin Tharp, PhD (UCSF); and Xiao Tian, PhD (Harvard Medical School).

A couple have already started their next chapters of their careers at Sanford Burnham Prebys, including already landing new grants! Others begin in January or March. Please welcome them.

These eight scientists represent the first wave. There are more to come, the benefit of Denny Sanford’s landmark gift early in 2023.

It has been a robust year in science at Sanford Burnham Prebys, too.

The Cancer Center received a merit extension from the NCI related to its support grant, a rare recognition of ongoing excellence. The Prebys Center for Chemical Genomics continues to be the go-to place for drug discovery, highlighted by a trio of recent awards totaling almost $25 million to pursue novel leads and promising therapies to treat all manners of addiction.

Sanford Burnham Prebys researchers are pushing boundaries across disciplines, from DNA loops in pediatric brain tumors and a sugar with anti-cancer properties to a heart attack study that could change regenerative medicine and discovering that an incurable liver disease might just be curable.

We’ve also welcomed two new trustees: Michael R. Cunningham, PhD and Lori Moore.

It’s been a busy year. It’s been a good year.

With all of you, next year will be even better.

Institute News

Sanford Burnham Prebys graduate student selected for prestigious Women in Science scholarship

AuthorMiles Martin
Date

June 20, 2023

Katya Marchetti, a young woman with brown hair against a background of yellow flowers

Katya Marchetti has had her heart set on research since childhood. Today, she’s a bright, confident scientist making her dream a reality at Sanford Burnham Prebys.

Katya Marchetti, a first-year PhD student in the lab of Karen Ocorr, PhD, was recently awarded an Association for Women in Science (AWIS) scholarship. This competitive award encourages outstanding women pursuing degrees in science, technology, engineering and mathematics (STEM) fields at San Diego colleges and universities.

“Receiving this recognition highlights the importance of advocating for women’s empowerment in STEM and fostering an inclusive and diverse scientific community,” says Marchetti.

Marchetti grew up in Bakersfield California and finished her undergraduate degree from UC San Diego in just three years. Last year, she enrolled as a graduate student at 21 years old, making her one of the youngest PhD students to ever join the Institute. For her, the AWIS award is a culmination of a lifelong enthusiasm for science, inspired and encouraged by her family.

“I’m a very curious person,” says Marchetti. “I just inherently have to know how everything works, and my dad is the one got me inspired and interested in exploring things. I am so grateful for the opportunities that he fought for me to have, because he gave me everything that he didn’t.”

With the enthusiastic support of her family, Marchetti began her research career at the ripe age of nine years old. 

“My first-ever science project was heart research,” she says. “My favorite song was “Kickstart My Heart” by Mötley Crüe, and I wanted to see if it would raise blood pressure. I tested myself and my family, and we actually found that it did, obviously.” 

Today, Marchetti’s heart research is a bit more sophisticated. She studies hypoplastic left heart syndrome (HLHS), a rare disease in which the left side of the heart is underdeveloped and unable to effectively pump oxygenated blood to the rest of the body. HLHS is a congenital disease that is nearly always fatal without heart surgery. Marchetti’s research focuses on uncovering the genetics that underpin this disease to find new ways to prevent and treat it.

“Researching heart disease is very rewarding in and of itself, but it’s also really motivating to work on a disease that occurs in one of the most vulnerable populations,” says Marchetti. 

Marchetti is also heavily involved on campus at the Institute, as one of just two graduate students to serve on the Institute’s Education and Training committee, part of the Institute’s Diversity Equity and Inclusion Council. She has also mentored interns for the Institute’s CIRM-sponsored SPARK program, which provides research experiences to high school students from underrepresented backgrounds.

“I really love mentoring people who don’t have a lot of lab experience,” says Marchetti. “It’s my favorite thing I’ve done in graduate school so far. I think that’s kind of my way of paying forward the opportunities that I’ve had.” 

Marchetti will use the funds from the AWIS scholarship to further support her HLHS research. She also maintains that even after finishing her PhD, her long-term goal is to continue working in the San Diego research community. 

“If were to describe myself as a city, it would be San Diego,” she says. “It’s really the perfect place for me.” 

Institute News

NIH grant aims to boost heart muscle

AuthorMonica May
Date

August 23, 2019

striated muscle fibers

Heart disease is the number one killer of Americans. Now, the National Institutes of Health (NIH) has awarded a four-year grant totaling nearly half a million dollars to Sanford Burnham Prebys to find medicines that could help people repair damaged heart muscle—and potentially reduce the risk of heart attack or other cardiovascular events. 

“Each year we lose far too many loved ones to heart attacks and other heart conditions,” says grant recipient Chris Larson, PhD, adjunct associate professor in the Development, Aging and Regeneration Program at Sanford Burnham Prebys. “Now, we have the opportunity to find medicines that may help more people live long, active lives by strengthening their heart muscles.”

Nearly half of American adults—approximately 120 million people—have cardiovascular disease, according to the American Heart Association and NIH. The condition occurs when blood vessels that supply the heart with oxygen and nutrients become narrowed or blocked, increasing risk of a heart attack, chest pain (angina) or stroke. Current medications for cardiovascular disease can lower blood pressure or thin the blood to minimize risk. Still, five years after a heart attack, 47% of women and 36% of men will die, develop heart failure or experience a stroke. No medicines that repair heart muscle exist. 

To identify drugs that may stimulate heart muscle growth, Larson and his team will screen hundreds of thousands of compounds against human heart muscle cells, called cardiomyocytes. The work will be done in collaboration with Alexandre Colas, PhD, assistant professor in the Development, Aging and Regeneration Program at Sanford Burnham Prebys, who developed the high-throughput screening system that will be employed.

Once the scientists identify drug candidates that promote heart muscle growth, they will study these compounds in additional cellular and animal models of heart disease in the hopes of uncovering insights into the biology behind the repair process. 

“After experiencing a heart attack or other cardiovascular event, many people live in fear that it will happen again,” says Colas. “Today we embark on a journey toward a future where people living with cardiovascular disease don’t have to be afraid of a second heart attack.”

Institute News

5 takeaways from Insights: Heart Disease

AuthorMonica May
Date

February 15, 2019

SBP Insights:Heart Disease

It’s easy to forget about the fist-sized organ in our chest. But the heart is arguably the most important muscle in the body. We can’t live without it, after all. 

To help educate the public about heart health and share the latest scientific advances, this month Sanford Burnham Prebys Medical Discovery Institute (SBP) invited the San Diego community to a free panel discussion focused on the heart. 

More than 70 community members attended the event, whose speakers included cardiologist Anthony N. DeMaria, MD; Jack White, chair in Cardiology, professor of Medicine, founding director, Sulpizio Cardiovascular Center at UC San Diego Health; Donna Marie Robinson, an individual living with heart failure; and heart researcher Karen Ocorr, PhD, assistant professor, Development, Aging and Regeneration Program at SBP. Jennifer Sobotka, executive director at the American Heart Association San Diego, moderated the discussion.

In a special introduction provided by Rolf Bodmer, PhD, director and professor in the Development, Aging and Regeneration Program at SBP, he explained that his heart research uses model organisms such as the fruit fly. He quipped, “Which some of you didn’t even know had a heart.” 

The ensuing discussion was robust and insightful. Below are five important takeaways: 

  1. Heart disease is the number-one killer of Americans. Nearly half of American adults have some form of heart or blood vessel disease.
  2. Obesity is an epidemic in America. In the 1960s, approximately 13 percent of American adults were obese, according to the Centers for Disease Control (CDC). Today, that number has tripled to nearly 40 percent. DeMaria illustrated this point with a colored map showing obesity’s prevalence during each decade, which drew gasps from the crowd. 
  3. Know your numbers. Donna Marie was healthy and fit, so she didn’t think that a fainting episode could have been heart disease. “My cardiologist saved my life,” she said. Now, she encourages everyone to “know your numbers, including your cholesterol level and your blood pressure.” 
  4. Rethink swatting that pesky fruit fly. We share 80 percent of disease-causing genes with the tiny insect, including ion channels that keep the heart pumping. For this reason scientists are studying fruit-fly hearts in an effort to learn about the many mysteries of the heart, such as how the rhythm disorder atrial fibrillation (AFib) arises. 
  5. Consider moving to Italy. Just about everyone wants to know which science-backed diet to follow for optimal health. DeMaria explained that the most robust data supports eating a Mediterranean diet rich in fruits, vegetables and olive oil.

Read the La Jolla Light’s coverage of the event. 

Institute News

American Heart Association awards postdoctoral fellowship to SBP scientist

AuthorMonica May
Date

January 23, 2019

Chiara Nicoletti, PhD, Sanford Burnham Prebys

It’s no surprise that muscles are important to our metabolism: it’s why building muscle at the gym can accelerate weight loss. 

Scientists are particularly interested in how muscle metabolism affects the heart, arguably the most important muscle in the body. With heart disease remaining the number-one killer of men and women in the U.S., the hunt is on to better understand the molecular mechanisms of the heart so we can develop better treatments. (Learn more about heart disease at our upcoming SBP Insights event.) 

Research is revealing that altered communications between skeletal and heart muscle increases the risk of heart disease. But the molecular mechanisms behind this link are currently unknown. 

Now, the American Heart Association has awarded a two-year postdoctoral fellowship to SBP’s Chiara Nicoletti, PhD, to study the genetic basis of metabolic changes in skeletal muscle that ultimately lead to heart disease. Nicoletti works in the lab of Pier Lorenzo Puri, MD, professor in the Development, Aging and Regeneration Program at SBP. 

Findings from Nicoletti’s work could uncover therapeutic targets for heart disease and/or lead to a prognostic tool that could predict heart disease risk. Both developments would be much-needed advances in the battle against heart disease. 

Interested in keeping up with SBP’s latest discoveries, upcoming events and more? Subscribe to our monthly newsletter, Discoveries.

Institute News

Peter Crawford, MD, PhD, elected to the American Society for Clinical Investigation

Authorjmoore
Date

April 19, 2016

Header image

The director of SBP’s Cardiovascular Metabolism Program was recently elected into a pre-eminent honor society for physician-scientists. Peter Crawford, MD, PhD, was one of 74 medical researchers whose nominations to the American Society for Clinical Investigation (ASCI) were accepted in 2016. This distinction is conferred only on investigators who have made significant scientific advances prior to the age of 50. Continue reading “Peter Crawford, MD, PhD, elected to the American Society for Clinical Investigation”