Jorge Moscat, Ph.D.

Jorge Moscat's Research Focus

Cancer, Metabolic Diseases, Inflammatory Bowel Disease, Inflammatory/Autoimmune Disease
Cancer Biology, Cancer Metabolism, Cell Signaling, Inflammation, Metabolic Signaling, Oncogenes
Cultured Cell Lines, Mouse
Cellular and Molecular Imaging

The signaling pathways that regulate inflammation and cell proliferation, and their interface with metabolism, are central in the control of tumor initiation and progression as well as in the development of metastasis. The study of these fundamental biological questions results in the identification of non-oncogenic and oncogenic vulnerabilities that will lead to the design of more efficacious and less toxic anti-cancer therapies.

Jorge Moscat's Research Report

We are interested in the study of these pathways in the context of the role and mechanism of action of a number of key signaling molecules, which include the autophagy and signaling adapters p62 and NBR1, and the kinases MEKK3, PKCζ and PKCλ/ι. All contain PB1 protein-protein interaction domains that confer selectivity to their mechanism of action, and make them attractive targets in cancer. My laboratory discovered p62 (Sanchez et al., MCB 18, 3069, 1998), which along with NBR1 are two proposed chaperones in autophagy, and we showed that both play critical roles as signaling adaptors in inflammation, metabolism and cancer. We were pioneers in the field and have demonstrated that p62 is a central molecule in cancer, beyond its role as autophagy substrate and adaptor. Studies ongoing in my laboratory are aimed at understanding how these signaling adaptors regulate the complex series of interactions in the tumor microenvironment, specially the cross-talk between the tumor epithelium and the stroma, in several types of cancers including pancreatic, liver and intestinal.

Likewise, we were the first to address the role of PKCζ in cell signaling (Berra et al., Cell 74, 555, 1993; Diaz-Meco et al., Cell 86, 777, 1996; Leitges et al., Mol. Cell 8, 771, 2001). Later, we were the first to demonstrate that, contrarily to previous assumptions based on cell lines and transfection experiments, PKCζ is a novel tumor suppressor and negative regulator of inflammation, metabolic reprograming, and stemness. More recent studies in our laboratory are focused on the signaling cross-talk between stem cells and Paneth cells in the intestinal niche, and how PKCζ and PKCλ/ι regulate intestinal cancer initiation in the context of the effect of inflammation and the microbiome. Our studies address these complex processes, and their underlying signaling pathways, by using physiologically relevant mouse models of colon cancer, and the interrogation of human samples. Specifically, this approach guarantees the importance of our findings and their potential impact in human disease.



Jorge Moscat's Bio

Dr. Moscat earned a bachelor’s degree in chemistry and a doctorate in biochemistry/molecular biology at the Universidad Complutense in Madrid, Spain. He completed postgraduate studies with fellowships of the Spanish Education and Science Ministry and Juan March Foundation in Madrid and at the NIH. Dr. Moscat joined the University of Cincinnati in 2006 from the Center of Molecular Biology of the Spanish National Research Council in Madrid, where he conducted cancer cell biology research, focusing primarily on signaling pathways in cancer, obesity and inflammation. In 2008, he became professor and chairman of the Department of Cancer and Cell Biology at the University of Cincinnati College of Medicine and associate director of basic science for the Cincinnati Cancer Consortium. Dr. Moscat joined the Institute's faculty in 2011.


1984: Ph.D., Universidad Complutense, Madrid, Biochemistry and Molecular Biology
1980: B.S., Universidad Complutense, Madrid, Biochemistry

Other Affiliations

Member of Editorial Boards
EMBO Journal
EMBO Reports

Honors and recognitions

Member of the Editorial Board of Molecular and Cellular Biology
2006: Elected Member of the Academia Europaea
2002: Member of the Editorial Board of EMBO Journal
2002: Member of the Editorial Board of EMBO Reports
2001: Award of the Juan March Foundation
2000: Award of the Carmen and Severo Ochoa Foundation
1999: Award of the Spanish Royal Academy of Sciences
1998: Award of the Foundation for Health Sciences
1995: Elected member of the European Molecular Biology Organization (EMBO)
1989 & 1991: Awards of the Spanish Cancer Scientific Association

CMSN Accessory


Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis.

Ma L, Tao Y, Duran A, Llado V, Galvez A, Barger JF, Castilla EA, Chen J, Yajima T, Porollo A, Medvedovic M, Brill LM, Plas DR, Riedl SJ, Leitges M, Diaz-Meco MT, Richardson AD, Moscat J

Cell 2013 Jan 31 ;152(3):599-611

Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis.

Valencia T, Kim JY, Abu-Baker S, Moscat-Pardos J, Ahn CS, Reina-Campos M, Duran A, Castilla EA, Metallo CM, Diaz-Meco MT, Moscat J

Cancer Cell 2014 Jul 14 ;26(1):121-135

p62 in Cancer: Signaling Adaptor Beyond Autophagy.

Moscat J, Karin M, Diaz-Meco MT

Cell 2016 Oct 20 ;167(3):606-609

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The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation.

Fischer K, Fenzl A, Liu D, Dyar KA, Kleinert M, Brielmeier M, Clemmensen C, Fedl A, Finan B, Gessner A, Jastroch M, Huang J, Keipert S, Klingenspor M, Brüning JC, Kneilling M, Maier FC, Othman AE, Pichler BJ, Pramme-Steinwachs I, Sachs S, Scheideler A, Thaiss WM, Uhlenhaut H, Ussar S, Woods SC, Zorn J, Stemmer K, Collins S, Diaz-Meco M, Moscat J, Tschöp MH, Müller TD

Nat Commun 2020 May 8 ;11(1):2306

NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly.

He F, Antonucci L, Yamachika S, Zhang Z, Taniguchi K, Umemura A, Hatzivassiliou G, Roose-Girma M, Reina-Campos M, Duran A, Diaz-Meco MT, Moscat J, Sun B, Karin M

J Hepatol 2020 Jun ;72(6):1182-1195

Serrated Colorectal Cancer: The Road Less Travelled?

Nakanishi Y, Diaz-Meco MT, Moscat J

Trends Cancer 2019 Nov ;5(11):742-754

The complexity of the serine glycine one-carbon pathway in cancer.

Reina-Campos M, Diaz-Meco MT, Moscat J

J Cell Biol 2020 Jan 6 ;219(1)

The Dual Roles of the Atypical Protein Kinase Cs in Cancer.

Reina-Campos M, Diaz-Meco MT, Moscat J

Cancer Cell 2019 Sep 16 ;36(3):218-235

Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer.

Reina-Campos M, Linares JF, Duran A, Cordes T, L'Hermitte A, Badur MG, Bhangoo MS, Thorson PK, Richards A, Rooslid T, Garcia-Olmo DC, Nam-Cha SY, Salinas-Sanchez AS, Eng K, Beltran H, Scott DA, Metallo CM, Moscat J, Diaz-Meco MT

Cancer Cell 2019 Mar 18 ;35(3):385-400.e9

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