Alessandra Sacco Archives - Sanford Burnham Prebys
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Experts exchange advances in the science of healthier aging in San Diego

AuthorGreg Calhoun
Date

April 1, 2025

Two scientific meetings in late March brought together researchers studying aging and its implications for disease

Scientists from San Diego and across the United States gathered March 26-27, 2025, to discuss the latest advancements in aging research. The NIH-funded San Diego Nathan Shock Center, a collaboration among the Salk Institute for Biological Studies, Sanford Burnham Prebys and the University of California San Diego, opened the two scientific meetings with its 2025 symposium on Wednesday, March 26, at the Salk Institute in the Conrad T. Prebys Auditorium in La Jolla.

The event focused on the center’s primary research area, “The Heterogeneity of Aging.” Just as people and organisms age at different rates, scientists have demonstrated that tissues also age at their own speeds – even some cells within tissues age at a unique pace. This phenomenon, known as heterogeneity of aging, is of great interest to researchers as it may hold clues for how to develop interventions that enable people to lead healthier lives as they age.  

The San Diego Nathan Shock Center Symposium convened 193 in-person attendees and another 113 virtual participants over Zoom.

Shanshan Yin, PhD, a postdoctoral associate in the lab of Peter D. Adams, PhD, director and professor in the Cancer Genome and Epigenetics Program at Sanford Burnham Prebys, presented an update on her research regarding breast cancer and aging. She discussed results from investigating changes in gene expression and immune system activity in breast cancer tumors as mice age, leading to increased cancer incidence. Yin was awarded a San Diego Nathan Shock Center pilot grant in 2023.

The 8th annual La Jolla Aging Meeting was held on Thursday, March 27, also in Salk’s Conrad T. Prebys Auditorium. The event brought together 257 in-person attendees and featured mostly short talks from San Diego-based postdoctoral fellows and students researching the biology of aging.

Kelly Yichen Li, PhD, a postdoctoral associate in the lab of Kevin Yip, PhD, interim director of the Center for Data Sciences and professor in the Cancer Genome and Epigenetics Program, delivered a talk regarding her work on zombie-like senescent cells that persist but no longer divide like most normal cells. Li discussed her work exploring cell types in samples of liver tissue. She discovered differences in cell composition and gene expression based on the age of the samples. Li and her collaborators continue to work on methods to identify senescent cells in tissue samples, which would accelerate research in the field.

Tatiana Moreno, a graduate student in the lab of Caroline Kumsta, PhD, associate dean of Student Affairs in the Graduate School of Biomedical Sciences and assistant professor in the Center for Cardiovascular and Muscular Diseases, detailed her studies regarding aging and the body’s cellular recycling system, a process called autophagy. Moreno discussed her findings measuring autophagy in blood samples drawn from human volunteers of various ages, including results regarding the effects of a 12-week exercise program.

Rouven Arnold, PhD, a postdoctoral associate in the Adams lab at Sanford Burnham Prebys, presented his work seeking to better understand how aging can lead to a loss of the unique cellular identity that allows cells to carry out specialized functions in different organs. Arnold focused on the HIRA protein, one of the histone chaperones responsible for helping to build spools out of histones used to hold DNA like a thread. Following studies of HIRA’s role in the aging liver, his results suggest that HIRA plays a protective role to preserve liver cell identity and promote healthy aging in the liver.

Alessandra Sacco, PhD, professor and director of the Development, Aging and Regeneration Program in the Center for Cardiovascular and Muscular Diseases at Sanford Burnham Prebys, and dean of the institute’s Graduate School of Biomedical Sciences, was a cohost for both events. Adams was a cohost for the La Jolla Aging Meeting.


About the San Diego Nathan Shock Center 
The San Diego Nathan Shock Center (SD-NSC), led by Gerald Shadel, PhD, Audrey Geisel Chair in Biomedical Science and professor in the Molecular and Cell Biology Laboratory at the Salk Institute, was established in the fall of 2020 with the overall goal of understanding the heterogeneity of aging in order to allow development of personalized interventions to increase the number of years of healthy life.

To this end, the center provides three novel scientific Research Resource Cores to develop new human cell models of aging and enable the integrated analysis of molecular, cellular and tissue heterogeneity. The SD-NSC also supports and advocates basic biology of aging research in general through the development, training and mentoring activities of a Research Development Core and robust outreach efforts. All of these activities are accomplished via a consortium of three premier research institutions on the La Jolla Research Mesa: the Salk Institute for Biological Studies, Sanford Burnham Prebys and the University of California San Diego.

Alessandra Sacco serves as director of the SD-NSC Research Development Core and Peter Adams serves as co-director of the SD-NSC Heterogeneity of Aging Core.

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Registration open for San Diego aging research meetings in March

AuthorGreg Calhoun
Date

March 12, 2025

There are two exciting opportunities in March for individuals interested in learning more about aging research conducted in San Diego and across the country.

San Diego Nathan Shock Center Symposium

On Wednesday, March 26, 2025, the San Diego Nathan Shock Center will hold its annual symposium on “The Heterogeneity of Aging” at the Salk Institute in the Conrad T. Prebys Auditorium and on Zoom. Speakers and topics for the event include:

  • Hongkui Zeng, PhD, Allen Institute for Brain Science – “Dynamic changes of cell types in the aging brain” 
  • Tony Wyss-Coray, PhD, Stanford University – “Young blood for old brains and the quest to slow aging” 
  • Adam Salmon, PhD, Barshop Institute at UT Health San Antonio – “Understanding the translational potential of geroscience from cells to primates” 
  • Lingyan Shi, PhD, University of California San Diego – “Optical Metabolic Nanoscopy for Studying Aging and Diseases” 

More information is available on the symposium website.

Register online to attend by Monday, March 17, 2025.


La Jolla Aging Meeting

The La Jolla Aging Meeting follows the next day on Thursday, March 27, 2025. It also will be held at the Salk Institute in the Conrad T. Prebys Auditorium. The event will include scientific presentations and networking with a focus on postdoctoral researchers and students.  

Nathan Le Brasseur, PhD, director of the Robert and Arlene Kogod Center on Aging at the Mayo Clinic, will present the keynote address. 

More information is available on the meeting website.  

Register online to attend by Monday, March 17, 2025.

Alessandra Sacco, PhD, professor in the Center for Cardiovascular and Muscular Diseases at Sanford Burnham Prebys, and dean of the institute’s Graduate School of Biomedical Sciences, is a cohost for both events. Peter D. Adams, PhD, director and professor in the Cancer Genome and Epigenetics Program at Sanford Burnham Prebys, is a cohost for the La Jolla Aging Meeting.


About the San Diego Nathan Shock Center
The San Diego Nathan Shock Center (SD-NSC), led by Gerald Shadel, PhD, Audrey Geisel Chair in Biomedical Science and professor in the Molecular and Cell Biology Laboratory at the Salk Institute, was established in the fall of 2020 with the overall goal of understanding the heterogeneity of aging in order to allow development of personalized interventions to increase the number of years of healthy life.

To this end, the center provides three novel scientific Research Resource Cores to develop new human cell models of aging and enable the integrated analysis of molecular, cellular and tissue heterogeneity. The SD-NSC also supports and advocates basic biology of aging research in general through the development, training and mentoring activities of a Research Development Core and robust outreach efforts. All of these activities are accomplished via a consortium of three premier research institutions on the La Jolla Research Mesa: the Salk Institute for Biological Studies, Sanford Burnham Prebys and the University of California San Diego.

Alessandra Sacco serves as director of the SD-NSC Research Development Core and Peter Adams serves as codirector of the SD-NSC Heterogeneity of Aging Core.

Institute News

Women in Science event at Sanford Burnham Prebys examines how female faculty members navigate research careers

AuthorGreg Calhoun
Date

August 19, 2024

Four panelists at different career stages shared insights and answered audience questions

Sanford Burnham Prebys held a Women in Science event on Monday, August 12, 2024. The session was in Fishman Auditorium on the Institute’s campus and focused on how female faculty members at different career stages have navigated their professional journeys in academia and the life sciences. 

Eric Wang,  PhD, an assistant professor in the Cancer Molecular Therapeutics Program at Sanford Burnham Prebys and co-chair of the Education and Training Diversity, Equity and Inclusion (DEI) Committee, opened the event and introduced the moderator, Shanshan Yin, PhD, a postdoctoral associate working in the lab of Peter D. Adams, PhD, and four panelists from Sanford Burnham Prebys: 

  • Caroline Kumsta, PhD, an assistant professor in the Development, Aging and Regeneration Program and associate dean of Student Affairs of the Graduate School of Biomedical Sciences 
  • Alessandra Sacco, PhD, the director of the Development, Aging and Regeneration Program and dean of the Graduate School of Biomedical Sciences 

Shanshan Yin, PhD, is a postdoctoral associate working in the lab of Peter D. Adams, PhD. She was the panel discussion moderator.

Work and life balance 

Yin asked the panelists to discuss how they balance their work and personal lives, and what strategies they use to restore their energy levels and maintain a positive mindset. 

“I had to learn to manage my schedule, rather than letting it manage me,” said Kumsta. “I’ve gained a greater appreciation for stepping away from problems, and I often find that I come up with new solutions during or after hiking or working out, instead of by just working more and more.” 

“Because I am setting up a new lab, it feels like I am working even more than I did as a postdoctoral fellow,” said Sun. “My persistence, curiosity and interest in the scientific process are the key drivers that are helping me as the lab gets up to speed.” 

Caregiving 

Yin followed this conversation by requesting that the panelists comment on the factors of childcare and family obligations throughout the careers of female faculty members. 

“The childcare system for working parents in the U.S. leaves a lot of room for improvement,” said Bradley. “This has not improved through the course of my career, and it is something we think about a lot within the Postdoctoral Training Advisory Group as we discuss ways to improve the experience of postdoctoral fellows at the institute.” 

Panelist Xueqin (Sherine) Sun, PhD, is an assistant professor in the Cancer Genome and Epigenetics Program.

“It can be hard to feel less productive as a scientist after having kids,” said Sun. “This is something we each have to navigate and there are no easy answers.” 

Audience questions 

Yin welcomed audience members to ask the panelists additional questions. 

Sacco fielded a question about the balancing act of working long hours for short-term gain versus the increased risk of burnout. She said, “For me, this has really happened in phases. Some parts of certain experiments or application cycles require extra effort, and you have to learn when you can pull back and have a more balanced schedule.” 

Kumsta answered a question about unrealistic expectations for postdoctoral fellows. She said, “I encourage every postdoc and principal investigator to have open and honest conversations about expectations for working hours, vacation time and weekend emails, among other topics. That won’t fix everything, but it will prevent a lot of uncertainty and build a foundation for addressing issues.” 

The panelists had noted the strong representation of male scientists and staff members in the audience. Sacco responded to a question about what male scientists could do better to improve the environment for women in the field. She said, “We should all recognize our own biases, minimize their impact when making decisions, and be good listeners to other scientists’ needs.”      

Gender and academic rank 

The event closed with a conversation about gender disparities in academic ranks at research and higher education institutions. The panelists focused on the attrition than can occur after the end of postdoctoral fellowships as a major challenge for retaining women in academic science.  

Kumsta explored some potential solutions that funders and institutions could consider. She said, “An extra year of funding for early-career female scientists and an extra year on the tenure clock may help us retain women and support their promotion from junior faculty positions. We also need to find ways to reward the extra administrative service that many female faculty members are asked to give on faculty committees.” 

Caroline Kumsta, PhD

Panelist Caroline Kumsta, PhD, is an assistant professor in the Development, Aging and Regeneration Program and associate dean of Student Affairs of the Graduate School of Biomedical Sciences.

“I think certain things are getting better, but we need to do even more to retain women in the field,” said Sun. “The National Institutes of Health allowing time and budget for childcare costs in training grants was an important step.” 

“Today’s event reminds us of the importance of speaking up,” said Sacco. “We can articulate and share our vision for a better tomorrow and work together to achieve it.” 

The Women in Science event was hosted by the Education and Training DEI Committee at Sanford Burnham Prebys and supported by the Institute’s Diversity, Equity, Inclusion and Belonging (DEIB) Council and DEIB program manager, Lauren Mitchell.  

Institute News

Sanford Burnham Prebys celebrates first graduate school Commencement ceremony

AuthorGreg Calhoun
Date

June 7, 2024

The Sanford Burnham Prebys Graduate School of Biomedical Sciences held its first-ever Commencement ceremony to celebrate nearly 20 years of educating future scientists

On Friday, May 31, 2024, the Sanford Burnham Prebys Graduate School of Biomedical Sciences hosted four graduates, their family members and friends as well as current students, faculty members and staff at the Institute’s campus in La Jolla for the school’s first-ever Commencement ceremony.

In addition to honoring the four graduates in attendance, the event also recognized the 62 other alumni who graduated from the Institute’s graduate school in the nearly 20 years since its founding in 2006.

“The graduate school is a direct extension of our commitment to training the next generation of scientists,” said David Brenner, MD, president, CEO and Donald Bren Chief Executive Chair at Sanford Burnham Prebys, during his welcoming remarks. “We focus on cultivating a collaborative culture where students are full participants. Thank you for your dedication to learning and creating new knowledge, and for your contributions to our mission of translating science to improve health.”

Brenner added, “We’re incredibly proud of you!”

Alessandra Sacco, PhD, director of, and professor in, the Development, Aging and Regeneration Program at Sanford Burnham Prebys, and dean of the Institute’s Graduate School of Biomedical Sciences, delivered the Commencement address.

“Hold onto perseverance and trust in yourself as you move forward,” said Sacco. “Never forget the sacrifices you have made, the hours in the lab and the failed experiments that have shaped you into better researchers.”

Sacco also remarked, “You are the next generation of scientists. You can make a difference by pushing on scientific boundaries while also having a positive influence on your communities.”

Alessandra Sacco, PhD, director of, and professor in, the Development, Aging and Regeneration Program at Sanford Burnham Prebys, and dean of the Institute’s Graduate School of Biomedical Sciences, delivered the Commencement address.

After concluding her remarks by wishing the graduates great success throughout their professional journeys, Sacco introduced Stephen Sakuma, PhD ’24, to speak on behalf of the Institute’s 66 alumni.

Stephen Sakuma, PhD ’24, spoke on behalf of the Institute’s
66 alumni.

“The faculty and community at Sanford Burnham Prebys have been tremendous and afforded me the most meaningful opportunities to learn and grow,” said Sakuma. “The journey has been long and, at times, arduous, but it also has been exceedingly rewarding.”

Diane Klotz, PhD, chief learning officer at Sanford Burnham Prebys, then discussed the meaning of the hoods and symbols that are used in Commencement ceremonies. She recognized the Institute’s alumni, both present and across the globe, and explained that all graduates are conferred degrees following the completion of all educational requirements and successful defense of their theses.

The Commencement ceremony, then, represents an opportunity to welcome back and celebrate with our alumni and their friends and family, and to pay tribute to alumni unable to attend who entrusted Sanford Burnham Prebys with their graduate education and preparation to enter the field of biomedical research.

Klotz invited the graduates forward and instructed faculty members to adorn them with the doctoral academic hoods signifying completion of a PhD program.

The graduates who attended the Commencement ceremony were:

  • Monica Gonzalez Ramirez, PhD ’18, who trained in the Salvesen lab and was hooded by Guy Salvesen, PhD, emeritus professor
  • James Kent, PhD ’22, who trained in the Marassi lab and was hooded by Dr. Guy Salvesen
  • Rachael McVicar, PhD ’23, who trained in the Snyder/Leibel lab and was hooded by Evan Snyder, MD, PhD, director of the Center for Stem Cells and Regenerative Medicine and professor in the Human Genetics Program
  • Stephen Sakuma, PhD ’24, who trained in the D’Angelo lab and was hooded by Maximiliano D’Angelo, PhD, associate professor in the Cancer Metabolism and Microenvironment Program

As the inaugural dean of the Institute’s graduate school, Salvesen provided the ceremony’s closing remarks. He wished the alumni well and supported Sacco’s assertion that their perseverance would be rewarded, which he reinforced with a quote from author and Arches National Park enthusiast Edward Abbey.

“May your trails be crooked, winding, lonesome, dangerous, leading to the most amazing view.”


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Opinion: Including researchers of diverse backgrounds makes science more accurate and applicable

AuthorAlessandra Sacco, Michael Jackson and Svasti Haricharan
Date

June 14, 2023

America has always been an experiment, an ongoing enterprise to determine how and how well people of different races, cultures and experiences might govern and live together. It’s an experiment that extends to every aspect of our lives. We celebrate our diversity and inclusivity through the food we eat, the languages we speak and the stories we tell.

Unfortunately, universities and other research institutions in the United States often do not have stories to tell about diversity and inclusion. People of color and women who aspire to careers in academic research are frequently discouraged early on from entering the grueling pipeline (which may extend more than a decade) by the lack of opportunities, access and accommodation.

It is no accident that non-White and female scientists are significantly and consistently underrepresented in the ranks of U.S. academic faculty: approximately 30 percent are female, just 6 percent are Black or Hispanic. Despite recent social awareness and movements toward change, the composition of tenure-track or tenured underrepresented faculty of color in the U.S. increased by only 1 percentage point (11 percent to 12 percent) between 2013 and 2019.

There are fundamental reasons why well-intentioned platitudes and policies regarding science and education don’t reflect reality. Neil A. Lewis Jr., a communications professor at Cornell University, wrote in a 2022 essay in Nature Human Behavior that “What counts as ‘good science’ tends to be research approaches that prioritize the experiences of dominant groups, and not approaches developed to prioritize people placed on the margins of society.”

He added, “The topics that count are ones that fit with the ‘master narratives’ in the field, and not the ‘counter narratives’ that sometimes emerge from marginalized groups.”

Many studies have demonstrated that the more diverse a research team is, the more likely its findings are to move fields forward and create new technologies and inventions. Simultaneously, research conducted by scientists who do not belong to dominant groups is more likely to be ignored by the larger research community, resulting in the so-called “diversity-innovation paradox” that slows scientific progress.

Historically, scientific and clinical studies have addressed research and health questions primarily through the prism of White males, overlooking or ignoring potential — or even likely differences — that might be found in women or people of color. As late as 1977, for example, the Food and Drug Administration recommended excluding women of childbearing potential from phase 1 and early phase 2 drug trials.

This is changing. It’s now well-documented that males and females differ in their response to drug treatment. Likewise, among different ethnicities. Inclusion is now law, and new research points to improved representation among communities of color in most clinical trials.

The embrace of science, technology, engineering and mathematics, or STEM, in public education has become a fundamental force for long-term good. The more children of every size, shape and color who are exposed to these disciplines, the more diverse and energized future generations of scientists, engineers and health professionals will be.

However, we are still in the first steps toward making this journey more accessible to marginalized groups. There is no mainstream movement yet in this direction. The ability to break into the upper echelons of academia continues to be constrained not only by race and ethnicity, but by privilege, with first-generation students facing many more barriers than those with at least one parent with a higher education degree. Scientists who are from the LGBTQ community also face significant challenges to finding acceptance for their research and their identity in academia.

A new educational program at Sanford Burnham Prebys, an independent biomedical research institute in La Jolla, attempts to remedy this singular reality. Funded by a grant from The Conrad Prebys Foundation, the institute has welcomed a group of 13 graduate students and postdoctoral fellows from diverse backgrounds and identities, all of whom will be working in labs, gaining hands-on experience in drug discovery and translational medicine from industry-trained researchers.

They come from near and far, having previously studied at places like San Diego State University, University of San Diego, University of Barcelona and Hong Kong University of Science and Technology. Their research interests are diverse: new treatments for breast and pancreatic cancers, how DNA repairs itself, regenerating heart muscle and how the brain protects itself from Alzheimer’s disease.

The goal is to provide these young scientists with advanced research training that will better position them to not just have successful, productive careers, but also become role models and leaders in biomedical research.

The Prebys Foundation fellows, as they are called, represent a small step in the right direction. Similar efforts are needed elsewhere, everywhere, at small and large institutions, laboratories and places where the work of science gets done.

As a nation, we must be committed to planting the seeds of new generations of scientists through programs like STEM. And when they begin to mature, we must provide the water and nutrients to ensure our young scientists bear fruit for a very long time.

Alessandra Sacco, PhD, is vice dean and associate dean of student affairs in the Graduate School of Biomedical Sciences at Sanford Burnham Prebys, and co-director of the fellowship program. Michael Jackson, PhD, is senior vice president for drug discovery and development and co-director in the Conrad Prebys Center for Chemical Genomics, and co-director of the fellowship program. Svasti Haricharan, PhD, is associate director for training and education in the NCI-Designated Cancer Center at Sanford Burnham Prebys. All live in San Diego.

This story originally appeared in San Diego Union-Tribune.

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New CIRM grant to fund research internships for underrepresented high school students

AuthorMiles Martin
Date

January 25, 2022

Thanks to a new grant awarded to Sanford Burnham Prebys by the California Institute for Regenerative Medicine (CIRM), 57 California high school students from underrepresented groups will have the chance to complete a paid internship at the Institute for the next five consecutive summers.

The $509,000 grant was awarded to Paula Checchi, PhD, Alessandra Sacco, PhD, and Evan Snyder, MD, PhD

The mission of CIRM is to accelerate stem cell research and provide treatment to patients with unmet medical needs. And although CIRM directly funds faculty, many of their initiatives also focus on training the next generation of stem cell researchers. Late last year, Sanford Burnham Prebys received $5 million from CIRM to fund new training programs aimed at PhD students and postdoctoral researchers.

“One of the benefits of a program like this is that we’ll be able to inspire students early to pursue biomedical research,” says Checchi, a principal investigators on the grant and longtime educator of high school and undergraduate students. “A lot of students might not even realize that pursuing a STEM degree is an option for them, and that’s something we want to change.” 

The new grant was awarded as part of CIRM’s SPARK Training Program, a diversity, equity and inclusion (DEI) initiative that targets high school students without access to summer research internship opportunities due to socioeconomic constraints. This grant is one of 11 awarded by CIRM to research institutions across California.

“At the high school level, a lot of research internships are unpaid, which can alienate a lot of students, especially if they’re also part of a group that isn’t represented well in scientific research to begin with,” says Checchi. “Programs like this help flip that script and will contribute to increased diversity in science over the long term.”

In addition to getting hands-on research experience, interns will also participate in community outreach, patient advocacy and other educational activities under the mentorship of experienced professors.

“The research element is obviously important, but programs like this also help students develop into confident, capable young scientists who are able to inspire those around them,” says Checchi. “We’re trying to plant the seed for these bright young minds to flourish.” 

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A year in review: Our top 10 discoveries of 2019

AuthorMonica May
Date

December 4, 2019

At Sanford Burnham Prebys, we uncover the origins of disease and launch bold new strategies that lay the foundation for achieving cures. This year our scientists made significant progress—revealing new insights into how we treat some of the deadliest cancers, address neurological disorders such as Parkinson’s and amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease) and more.

Read on to learn more about our top 10 discoveries of the year. To receive more frequent updates on our discoveries, subscribe to our monthly newsletter at the bottom of this page.

  1. One-two punch drug combination offers hope for pancreatic cancer therapy. Ze’ev Ronai, PhD, identified a combination of two anti-cancer compounds that shrank pancreatic tumors in mice—supporting the immediate evaluation of the drugs in a clinical trial. The study was published in Nature Cell Biology.
  2. Targeted treatment shrinks deadly pediatric brain tumors. Robert Wechsler-Reya, PhD, reported that a targeted therapy that blocks a protein called LSD1 shrank tumors in mice with a form of pediatric brain cancer known as medulloblastoma. LSD1 inhibitors are currently under evaluation in clinical trials for other cancers, which could speed their potential path to children. The study was published in Nature Communications.
  3. Epigenetic change causes fruit fly babies to inherit diet-induced heart disease. Rolf Bodmer, PhD, showed that reversing an epigenetic modification or over-expressing two genes protected fruit fly children and grandchildren from the negative heart effects of their parents’ fatty diet. These findings help explain how obesity-related heart failure is inherited and uncover potential targets for treatment. The study was published in Nature Communications.
  4. Amyotrophic lateral sclerosis (ALS) research reveals new treatment approach. Huaxi Xu, PhD, extended the survival of mice with ALS-like symptoms by elevating levels of a protein called membralin using a gene therapy approach. The study was published in the Journal of Clinical Investigations.
  5. How prostate cancer becomes treatment resistant. Jorge Moscat, PhD, and Maria Diaz-Meco, PhD, identified how prostate cancer transforms into an aggressive, treatment-resistant subtype called neuroendocrine prostate cancer (NEPC) following treatment with anti-androgen therapy. Their findings uncover new therapeutic avenues that could prevent this transformation from occurring and reveal that an FDA-approved drug holds promise as an NEPC treatment. The study was published in Cancer Cell.
  6. Boosting muscle stem cells to treat muscular dystrophy and aging muscles. Alessandra Sacco, PhD, uncovered a molecular signaling pathway that regulates how muscle stem cells decide whether to self-renew or differentiate—an insight that could lead to muscle-boosting therapeutics for muscular dystrophies or age-related muscle decline. The study was published in Nature Communications.
  7. Functional hair follicles grown from stem cells. Alexey Terskikh, PhD, created natural-looking hair that grows through the skin using human induced pluripotent stem cells (iPSCs), a major scientific achievement that could revolutionize the hair growth industry. Stemson Therapeutics has licensed the technology.
  8. Potential targeted treatment for acute myeloid leukemia identified. Ani Deshpande, PhD, showed that a protein called BMI1 is a promising drug target for an AML subtype in which two normally separate genes fuse together. The findings, published in Experimental Hematology, provide a rationale for evaluating a BMl1-inhibiting drug that is currently in clinical development as a potential treatment for this subtype.
  9. Antimicrobial protein implicated in Parkinson’s disease. An immune system protein that usually protects the body from pathogens is abnormally produced in the brain during Parkinson’s disease, Wanda Reynolds, PhD, reported in Free Radical Biology & Medicine. The discovery indicates that developing a drug that blocks this protein, called myeloperoxidase (MPO), may help people with Parkinson’s disease.
  10. Digestion-aiding herbs alter gut microbiome. Scott Peterson, PhD, found that four herbs—turmeric, ginger, long pepper and black pepper—promoted strong shifts in the gut bacteria that are known to regulate metabolism, providing insights that could help us protect our health. The study was published in Evidence-Based Complementary and Alternative Medicine.
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Teaching stem cells to build muscle

Authorjmoore
Date

February 18, 2016

Researchers in Alessandra Sacco’s lab have found a key to enhancing repair of damaged muscle. In work published in Cell Reports, they describe why fetal muscle stem cells (MuSCs) are better at regenerating muscle compared to adult MuSCs. The research opens the door for new approaches to treat muscle diseases including muscular dystrophies, which affect approximately 50,000 people in the U.S., and muscle wasting associated with cancer and aging.

“We found that fetal MuSCs remodel their microenvironment by secreting specific proteins, and then examined whether that same microenvironment can encourage adult MuSCs to more efficiently generate new muscle. It does, which means that how adult MuSCs normally support muscle growth is not an intrinsic characteristic, but can be changed,” explained Matthew Tierney, a graduate student at SBP and first author of the study.

The proteins that fetal MuSCs secrete are part of the extracellular matrix (ECM), the meshwork of strand-like proteins and starches that make up the structure of MuSCs’ microenvironment. As fetal MuSCs mature into adult MuSCs, they take on different responsibilities and help change their microenvironment over time to support their distinct functions. Fetal MuSCs are geared toward creating new muscle, whereas adult MuSCs repair damaged muscle and self-replicate to sustain the pool of stem cells to mend future injuries.

In muscular dystrophies and muscle wasting, progressive degeneration overwhelms the regenerative capacity of adult MuSCs. The new study showing that adult MuSCs living in a microenvironment with fetal characteristics are better at regenerating muscle provides rationale for developing drugs that could trigger this transition.

“These results help explain the differences between the capacity of fetal and adult MuSCs to repair muscle. Such an understanding is urgently needed, as no treatments are yet available for muscular dystrophies and muscle-wasting disorders,” stated Alessandra Sacco, PhD, associate professor in the Development, Aging, and Regeneration Program at SBP and senior author of the study.

“Our findings fit with the growing appreciation of the importance of a cell’s structural and biochemical surroundings in influencing cellular behavior. Managing the microenvironment is an emerging approach to treat many diseases, from cancer to cardiovascular disease to neurodegeneration. We’re excited about the implications of our research for treating muscle diseases, and look forward to applying our conclusions toward development of therapies.”

The full text of the paper is available here.

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2015 Sanford-Burnham faculty retreat

Authorsgammon
Date

June 5, 2015

The annual Sanford-Burnham faculty retreat was held in beautiful Carlsbad, Calif., May 19-20. Attended by more than 70 faculty from La Jolla, Calif., and Lake Nona, Fla., the retreat was an opportunity for attendees to learn more about each other’s research, share ideas, and to engage in strategic discussions related to the Institute’s 10-year vision to become a preeminent medical research institute that combines cutting-edge fundamental research with robust drug discovery. Continue reading “2015 Sanford-Burnham faculty retreat”

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Happy Holidays from Sanford-Burnham!

Authorpbartosch
Date

December 23, 2014

As the year draws to a close, we look back on Sanford-Burnham’s many achievements in 2014. Over the year, our scientists published numerous papers in high-profile journals; secured significant grant funding; partnered with companies, institutes, and nonprofit organizations from across the country and the globe; and they took important steps toward our ultimate goal – to have a tangible impact on human health. Here are 14 accomplishments of 2014 that we are proud to share with you: Continue reading “Happy Holidays from Sanford-Burnham!”