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Institute News

19th annual Trainee Research Symposium is a virtual success!

AuthorSusan Gammon
Date

October 5, 2020

Virtual Symposium on Zoom

Sanford Burnham Prebys’ annual Trainee Research Symposium is dedicated to highlighting the research of postdoctoral scientists and advanced graduate students.

This year, nearly 40 early-career scientists presented their research during an engaging two-day, jam-packed Zoom call that went off without a hitch.

After opening remarks by Malene Hansen, PhD, professor and faculty adviser for Postdoctoral Training, the podium and poster presentations began. Faculty, trainees, staff scientists and other interested parties navigated through sessions that ranged from new approaches to conquer brain cancer to the molecular basis of aging. The event gives “up-and-coming” scientists an opportunity to receive feedback on their work, explore potential new collaborations and receive prize money to support career development activities.

“We’re fortunate to be starting our careers at Sanford Burnham Prebys where the scientific research is significant and diverse,” says Cynthia Lebeaupin, PhD, a best poster presentation award winner. “I’m grateful to be able to present my project, which is focused on the link between fatty liver disease and cancer, to colleagues from different disciplines, such as cardiac disease and immunology. Their questions about my research bring fresh perspectives and spark new ideas.”

Keynote speaker Martin Chalfie, PhD, a Nobel Laureate in Chemistry and professor at Columbia University, opened day two of the event with a presentation titled, “GFP: Lighting Up Life,” detailing the journey that led to his discovery of GFP—a fluorescent protein that revolutionized how scientists look at the inner workings of living cells. Chalfie followed with an informal “Ask Me Anything” session where he shared his passion for mentoring early-career scientists.

C. Randal (Randy) Mills, PhD, CEO of Sanford Burnham Prebys, closed the event with a happy hour exclusively attended by trainee presenters—an opportunity for everyone to get to know more about his experiences as a PhD student and how his career evolved to his current position as leader of our world-class biomedical research Institute.

Many congratulations to all who participated in the symposium, and thanks to the organizers at the SBP Science Network and the Office of Education, Training, & International Services (OETIS).

This year’s symposium winners are:

Best Podium Talk – Judges Selection

Natalie Kirkland, PhD
Engler/Bodmer Labs
Runner-up
Stephen Sakuma
D’Angelo Lab

Honorable Mentions

Mallika Iyer
Godzik Lab
Jaime Zlamal, PhD
Osterman Lab

Best Poster –Judges Selection

Cynthia Lebeaupin, PhD
Kaufman Lab
Rashmi Mishra, PhD
Dong Lab
Ee Phie Tan, PhD
Hansen Lab

Best Podium Talk – Popular Vote

Stephen Sakuma
D’Angelo Lab

Honorable Mention

Jaime Zlamal, PhD
Osterman Lab

Institute News

Families, physicians and scientists unite at Sanford Burnham Prebys’ 11th Annual Rare Disease Day Symposium

AuthorMonica May
Date

March 16, 2020

Rare Disease Day group photo

This year’s event centered on CDG, a rare genetic condition that affects around 1,500 people worldwide.

With more than 270 attendees and 30 world-renowned scientists and clinicians, Sanford Burnham Prebys’ 11th Annual Rare Disease Day Symposium was officially the largest in the event’s history. This year’s discussion centered on congenital disorders of glycosylation, or CDG, a rare genetic condition that affects around 1,500 people worldwide.

Malin Burnham, T. Denny Sanford and Debra Turner, honorary trustees of Sanford Burnham Prebys, opened the three-day meeting with moving remarks. A theme emerged: Medical advances are accelerated when key stakeholders work together—including scientists, physicians, people with CDG and their families, patient advocacy groups, granting agencies, industry and philanthropists.

“Our annual symposium aims to create an ecosystem in which key stakeholders can collaborate and communicate,” said Hudson Freeze, PhD, director of the Human Genetics Program at Sanford Burnham Prebys and symposium chair. “Together, we celebrate our successes, focus on challenges and discuss the future of CDG research.”

Presenters at the meeting described the power of the ecosystem. Since the first conference a decade ago where scientists reported on the basic biology of CDGs, today we have promising clinical trials for the most common CDG mutation. In addition, a historic nationwide effort to establish the natural history of CDGs launched this year—which addresses decades of unresolved questions and helps remove barriers to starting clinical trials.

First discovered in the 1990s, scientists now know that CDG is caused by mutations that disrupt the body’s normal process of attaching sugars to proteins. Children with CDG have varying degrees of speech and language difficulty, poor balance, motor control, vision problems, hearing impairments and seizures. 

Because CDG is rare, many patients bounce between doctors and clinics for years before they receive an accurate diagnosis. At the symposium, an innovative session called the “Doctor-is-in” session connects families with medical researchers and clinicians in small groups. For some medical researchers, the session is the first time they have met a person with CDG.

The conference was co-organized by Sanford Burnham Prebys and CDG CARE, a nonprofit organization founded by parents seeking information and support for CDG.

Institute News

Starving the “world’s toughest cancer”

AuthorMonica May
Date

November 18, 2019

Moderator Andrea Decker of the Fleet Science Center; Darren Sigal, a clinician at Scripps Health; Russell Gold, a pancreatic cancer survivor; and Cosimo Commisso, a researcher at Sanford Burnham Prebys

Russell Gold is lucky to be alive. Only 9% of people with pancreatic cancer survive longer than five years—making it one of the deadliest cancers. This January, he will be a six-year survivor. 

To help the public better understand what makes pancreatic cancer so lethal—and how we can develop medicines so there are “more of me,” as Gold said—our Institute teamed up with the Fleet Science Center to host a panel discussion on Sunday, November 17. Gold was joined by a clinician and a scientist who both work on pancreatic cancer: Darren Sigal, MD, of Scripps Health; and Cosimo Commisso, Ph.D., an assistant professor at Sanford Burnham Prebys’ National Cancer Institute (NCI)-designated Cancer Center, respectively. 

As the speakers explained, pancreatic cancer is often difficult to diagnose because symptoms—such as pain in the abdomen, yellow skin and eyes, and weight loss—do not typically occur until the disease is advanced. As a result, pancreatic cancer is the 11th most common cancer but the second-leading cause of cancer death. More than 56,000 Americans are expected to receive a pancreatic cancer diagnosis in 2019, according to the American Cancer Society. 

Commisso, who was recently named a NextGen Star by the American Association for Cancer Research, is hopeful that his research will lead to effective treatments for pancreatic cancer. Commisso’s research focuses on how rapidly growing pancreatic tumors scavenge nutrients using an alternative supply route, called macropinocytosis. His lab has found that blocking this process, often described as “cellular drinking,” causes pancreatic tumors to shrink—indicating that the approach could lead to tumor-starving drugs. 

This event was the fourth of our five-part “Cornering Cancer” series. Register today to join us for a discussion on pediatric brain cancer in December.

Institute News

Top neuroscientists gather at Sanford Burnham Prebys’ annual symposium

AuthorMonica May
Date

November 18, 2019

Symposium organizers Jerold Chun (fourth from right), Randal Kaufman (second from left), Barbara Ranscht (third from right) and Huaxi Xu (far left), pose with the speakers

A mother who no longer remembers her son. A daughter who took doctor-prescribed pain medication and slipped into addiction. A father who has trouble grasping a pen and eventually becomes unable to walk. Neurological disorders are some of the most painful and complex conditions our society faces today. Yet much about the brain remains unknown, hindering our ability to help people with these disorders.

To help shed light on the brain’s mysteries, on November 1, 2019, more than 250 neuroscientists gathered at Sanford Burnham Prebys’ one-day symposium to share their latest discoveries. Organized by professors Jerold Chun, MD, PhD; Randal Kaufman, PhD; Barbara Ranscht, PhD; and Huaxi Xu, PhD, the event attracted scientists from around the world eager to learn more about biological clues that are leading to effective therapies. Read the full list of the invited speakers and their talks.

“Nearly every day we read about the toll neurological diseases such as Alzheimer’s, dementia, mental health disorders and more take on our society,” said Kristiina Vuori, MD, PhD, president of Sanford Burnham Prebys, in her introductory address. “Our symposium brings together scientists at the frontiers of brain research who share their latest discoveries to open new paths toward new and better treatments.”

More than 50 million Americans are affected by neurological disorders, including Alzheimer’s disease, dementia, addiction and more, according to the National Institute of Neurological Disorders and Stroke. Most of these conditions are not well addressed by current medicines.

At the symposium, world-renowned scientists from Stanford University, Mount Sinai, University of Vienna and other top-tier institutes gave talks describing their strategies to uncover the molecular basis of brain disorders and how these discoveries are advancing potential therapies. A national plan to address Alzheimer’s and other dementia types was described by Eliezer Masliah, MD, the National Institute of Aging’s director of the Division of Neuroscience.

“This was my first scientific conference, and it was perfect for learning about a wide range of cutting-edge brain research,” said attendee Jaclyn Beck, a PhD student at UC Irvine who studies the role of the brain’s immune cells, called microglia, in Alzheimer’s disease. “I have several pages of notes from the talks detailing findings I want to investigate and people I want to contact.”

For the past 40 years, our Institute has invited leading experts on one scientific topic to share their latest research at an annual symposium. By encouraging connection and collaboration, we hope to inspire insights that improve human health. The 41st annual symposium will take place in November 2020 and focus on the biology of organelles, specialized pouches within cells that carry out critical functions such as generating power and breaking down waste, and its role in health and disease.

Institute News

Advancing life-changing science at Sanford Burnham Prebys’ 2019 gala

AuthorMonica May
Date

November 13, 2019

From left to right: Honorary co-chairs Jeanne Jones and Reena Horowitz pose with our namesake Denny Sanford at our annual gala.

On November 2, 2019, more than 170 supporters of Sanford Burnham Prebys stepped into a winter wonderland at our Institute’s “Nordic Nights”-themed gala.

As attendees enjoyed the festivities—including an ethereal violinist on stilts and dancing ballerinas—the evening’s goal was never far from everyone’s mind: advancing biomedical research that will transform the future of human health. Thanks to guests’ generous donations our scientists can accelerate their efforts to understand and treat serious diseases such as Alzheimer’s, heart disease, cancer and more.

Watch Helen share her breast cancer story
(video shown at the gala)

Institute News

On the path to personalized breast cancer treatments

AuthorMonica May
Date

October 24, 2019

Fleet Cancer series-breast cancer

Ruth Claire Black wasn’t entirely surprised when she was diagnosed with breast cancer six and a half years ago. Her mother had died at age 52 of breast cancer, only two years after she was first diagnosed, Black explained at our recent Fleet Science Center event. New treatments have allowed Black’s story to differ from her mother’s—but as breast cancer experts from Sanford Burnham Prebys and UC San Diego Health explained, there is still a long way to go. 

“There is a great misconception that breast cancer is extremely easy to treat and is always cured. But the truth is that one in three women with early-stage breast cancer will relapse and eventually die from the disease,” said speaker Rebecca Shatsky, MD, a breast cancer oncologist at UC San Diego Health. “We are learning there aren’t one or two kinds of breast cancer—there are up to 30 different subtypes. To cure breast cancer, we need to look at treatments through a personalized lens.” 

Breast cancer is the second most common cancer in American women. One in eight women will be diagnosed with breast cancer in her lifetime, and more than 40,000 women die each year from the cancer. Targeted treatments—such as those that block the HER2 receptor—and hormone-based therapies have extended survival. However, 30% of people with estrogen-positive breast cancer, the most common form, eventually stop responding to standard-of-care treatments, for reasons that are largely unknown.

Speaker Svasti Haricharan, PhD, assistant professor at Sanford Burnham Prebys, is working to change these realities. Her work centers on a breast cancer subtype caused by defects in DNA repair machinery—a genomic “spell check” that normally corrects DNA copy errors during cell division. Nearly 20% of people who do not respond to breast cancer treatment have mutations in this machinery. Working with Shatsky, Haricharan’s team identifies breast cancer samples that have DNA damage repair defects. Then she tests these samples against thousands of FDA-approved treatments—with the goal of finding an effective treatment. 

For people like Black, these advances can’t come soon enough. 

“We have so much information about breast cancer. We have great diagnostics. Because of these tests, I know I’m a carrier of the BRCA2 mutation. I also know that it’s only a matter of time until my cancer returns,” said Black, who is a member of Sanford Burnham Prebys’ Community Advisory Board. “But doctors don’t know what to do with all of this information. That’s why I’m so supportive of the work taking place at Sanford Burnham Prebys. They are taking this information and doing something with it.” 

This event was the third of our five-part “Cornering Cancer” series. Register today to join us for discussions on pancreatic cancer in November and pediatric brain cancer in December. 
 

Institute News

Sanford Burnham Prebys welcomes U.S. Congressman Mike Levin

AuthorMonica May
Date

October 22, 2019

Congressman Mike Levin visits SBP

On October 1, 2019, U.S. Representative Mike Levin (D-CA) toured Sanford Burnham Prebys and met with several faculty members to learn more about the innovative biomedical research taking place in his backyard. Levin represents California’s 49th Congressional District, which includes North County San Diego, South Orange County and neighbors our La Jolla campus. 

The visit kicked off with a visit to a lab working to find medicines for a heart arrhythmia condition called atrial fibrillation (AFib), a disorder that hits home for Levin: His grandmother struggled with the disease. Levin peered into a microscope to view beating heart cells and learned how a team of experts from Sanford Burnham Prebys and Scripps Clinic are working to develop personalized treatments for the condition, which affects nearly six million Americans (meet the A-team.)

“Sanford Burnham Prebys is a great example of the vibrant biomedical research taking place in San Diego that has the potential to improve the quality of life for families across the country,” says Levin. “Seeing the Institute’s critical research up close and hearing firsthand how National Institutes of Health (NIH) funding has accelerated medical discovery only strengthens my commitment to supporting biomedical science. Following my visit to Sanford Burnham Prebys, I was proud to introduce legislation that would invest $10 billion in the NIH to support biomedical research, and I will continue to fight for this much-needed funding.”

Following the lab tour, Levin met with faculty members who—thanks to federally funded research—are working to find treatments for Alzheimer’s disease and addiction, and study the aging process to address age-related diseases such as cancer. The visit wrapped up in the lab of Hudson Freeze, PhD, the director of our Human Genetics Program, who studies a rare childhood disease called congenital disorders of glycosylation, or CDG. 

“Americans today are living longer and healthier lives because of federally funded medical research,” says Chris Larson, PhD, the adjunct associate professor of Development, Aging and Regeneration at the Institute who arranged the visit. “We are grateful that Mike took the time to sit down with us to learn about our NIH-funded work and how he can help support us on our mission to find cures for human disease.”

Editor’s note: Shortly after his visit Levin introduced legislation that calls for a $10 billion investment in biomedical research. 

Institute News

“We are desperate for new therapies”

AuthorMonica May
Date

September 23, 2019

Fleet Science Center: Cornering Cancer

Experts discuss AML during the Sanford Burnham Prebys community lecture series 

Bill Veljovich had never been sick in his life. “Not even joint pain,” shared the 80-year-old retired engineer at our recent Fleet Science Center discussion about acute myeloid leukemia (AML), a life-threatening type of blood cancer. He was joined by experts from Sanford Burnham Prebys and UC San Diego Health.
 
However, his doctor noticed that his white blood cells counts were off during a routine blood test. He was diagnosed with a blood cancer called myelodysplastic syndrome (MDS), which progressed to AML (this occurs in one out of three people with MDS). Fortunately, Veljovich responded well to a then off-label treatment that only recently was approved for older patients with AML. 

“The truth is, we are desperate for new therapies,” said speaker Rafael Bejar, MD, PhD, a clinician at UC San Diego who specializes in blood cancers. “AML typically occurs in people over the age of 60, who often aren’t able to tolerate intensive chemotherapies.” 

Until two years ago, the treatments for AML remained the same as those used in the 1970s: a chemotherapy combination and perhaps a bone marrow transplant. Only 24% of adults with AML remained alive five years after treatment. 

Now, thanks to foundational research that revealed the underlying genetic drivers of AML, eight new drugs have been approved in the past two years. Several more targeted therapies are nearing potential FDA approval. 

However, AML, which usually arises in cells that turn into white blood cells, is an incredibly complex and fragmented disease. Genome sequencing has revealed that more than 30 genes drive the cancer. Many different treatment types will be needed to truly conquer AML.

Peter Adams, PhD, a professor in Sanford Burnham Prebys’ National Cancer Institute (NCI)-designated Cancer Center, hopes to find a treatment that works for a broader AML population. He focuses on a protein called p53, often called the “guardian of our genome.” This protein senses DNA damage and kills the faulty cell—protecting us from developing cancer. However, to scientists’ surprise, 90% of people with AML have a normal p53 gene. 

“Emerging research suggests that AML inactivates p53 through other means,” said Adams. “My team is working to develop a drug combination that could reactivate the protective powers of p53—and thus fight AML.”

New research advances can’t come soon enough for people living with the cancer. 

“I’ve always taken the approach of learning as much as possible—and then fixing the problem,” said Veljovich, who designed and tested rocket engines before he retired. “I have learned that blood cancers are extremely complex. I wish there was a simple solution, but there isn’t. I’m grateful that we have smart folks like Dr. Bejar and Professor Adams who are working on these tough problems to find better medicines for AML.”

This event was the second of our five-part “Cornering Cancer” series. Join us for discussions on breast cancer (October 20), pancreatic cancer (November 17) and pediatric brain cancer (December 8). Register today.

Institute News

18th Annual Fishman Fund Award ceremony celebrates the next generation of biomedical trailblazers

AuthorSusan Gammon
Date

September 23, 2019

2019 Fishman Fund Award winners, left to right: Jennifer Hope, PhD, Aaron Harvas, PhD, Mafalda Loreti, PhD

Three talented early-career researchers were presented with a prestigious Fishman Fund Award at the annual ceremony on September 19. More than 100 generous benefactors, past award winners and family and friends joined the celebration held at the Sanford Consortium. The awards honor the Institute’s founders, Dr. William and Lillian Fishman.

Reena Horowitz, who along with her close friend Mary Bradley established the Fishman Fund Awards, welcomed the audience and shared how the Fishmans truly believed that young researchers need a boost from time to time—and that these awards do exactly that. Recipients who are selected from a pool of Sanford Burnham Prebys postdocs use the $10,000 stipend to attend workshops, network and travel to national and international conferences to learn about the latest developments in their research fields. 

“The young researchers at Sanford Burnham Prebys make discoveries that have an impact in San Diego as well as helping advance science and health around the world,” said Horowitz. “The Institute motto could not ring truer: From Research the Power to Cure.”

Professor Hudson Freeze—one of the very first Fishman Fund Award winners and now director of the Institute’s Human Genetics Program—shared how his nearly 40 years of research has established him as a magnet for a global community of families seeking treatments for rare childhood diseases. He encouraged this year’s winners to take advantage of working in a world-class research center and to pursue meaningful research that will open new avenues to improve human health.

Jennifer Hope, PhD, was presented with the Lenka Finci and Erna Viterbi Fund Prize by Horowitz and Institute supporter Judy White. Dr. Hope works in the laboratory of Professor Linda Bradley, where she is studying cellular and molecular mechanisms that drive the development of T cells that attack cancer. Jennifer’s career goal is to become an independent investigator focused on research to promote patient responsiveness to cancer therapies.

Mafalda Loreti, PhD, was presented with the Jeanne Jones and Kathryn Fishback Fund Prize by Fishman Fund co-founder designee Jeanne Jones and longtime Institute supporter Sam Horowitz. Dr. Loreti is studying the mechanisms that promote muscle growth and repair in the laboratory of Associate Professor Alessandra Sacco. Her career goal is to become an independent researcher in an academic setting, where she will explore the biology of muscle pathologies and approaches to improve muscle health.

Aaron Havas, PhD, received the Reena Horowitz and Mary Bradley Fishman Fund Prize from Horowitz and Institute supporter Doreen Schonbrun. Dr. Havas works in the lab of Professor Peter Adams, where he studies how aging affects gene regulation. His career goal is to work in the biotech industry exploring drugs that target the process to promote healthy aging.

Since the fund’s inception in 2001, 64 prizes have been awarded. Every other year, a 24-month fellowship that provides salary support is given to a deserving postdoc. The fellowship was awarded in 2018, so it will be given again at next year’s ceremony.

The generosity of our Fishman Fund donors enables the tradition of providing career advancement opportunities. On behalf of all of us at Sanford Burnham Prebys, we thank you for your support.

Institute News

Fleet Science Center cancer series kicks off with lung cancer discussion

AuthorMonica May
Date

August 22, 2019

Fleet Science Center-Garth Powis, Steven Snyder, Hatim Husain

New lung cancer treatments are making a difference for patients. Pill-based, personalized medicines and immunotherapies are allowing some individuals to survive for years instead of months. Still, lung cancer remains the deadliest cancer—killing more people each year than breast, prostate and colorectal cancer combined. 

To help the public better understand the newly available medicines—and the research advances on the horizon—our Institute teamed up with the Fleet Science Center to host a panel discussion on Sunday, August 18. 

“Many people who live in San Diego aren’t aware of the incredible research advances taking place in their backyard, especially in cancer,” said speaker Garth Powis, D. Phil., professor and director of Sanford Burnham Prebys’ National Cancer Institute (NCI)-designated Cancer Center (on left). “We hope this discussion and future events will help more people understand cancer research and the breakthroughs that might come from their own community.”

Powis was joined by Hatim Husain, MD, a clinician at UC San Diego (on right); and Steven Snyder, PhD, president and CEO of the Fleet Science Center (center), who moderated the discussion. The speakers described how targeted treatments, which are only prescribed if a patient’s tumor has a specific mutation; and immunotherapies, which harness a patient’s immune system to melt the tumor, are extending survival for lung cancer patients. Husain expressed excitement surrounding new blood tests to detect lung cancer—which he hopes will be more commonplace in five to ten years. The speakers also noted that advances made in lung cancer have the potential to extend to other tumor types. 

“Many of the mutations that drive lung cancers are found in other tumors,” said Husain. “Targeted treatments that shrink lung tumors are being studied broadly in patients with a variety of cancers.” 

Powis and Husain also touched on their own collaboration to learn how lung cancer becomes resistant to treatment. Fluid buildup in the pleural space, the area between the lungs and chest wall, is often removed during routine checkups to help patients breathe. Working with Husain, Powis’ team is tracking the cellular and molecular makeup of this pleural fluid over the course of the disease. By regularly analyzing this fluid, they hope to gain insights into how lung cancer becomes treatment resistant and how it can be stopped.

“Scientists are getting close to mapping all of the mutations that drive lung cancer growth,” said Powis. “One day, patients may take one pill that contains all the anti-cancer compounds they need to fight the tumor.”

Upcoming topics in the series include breast, brain, and pancreatic cancer and more. The events will take place from 7:00 p.m. to 8:30 p.m. on select Sundays in the Heikoff Giant Dome Theater at the Fleet Science Center in San Diego. Space is limited. Reserve your ticket today.