Institute News

Sanford Burnham Prebys welcomes U.S. Congressman Mike Levin

AuthorMonica May

Date

October 22, 2019

On October 1, 2019, U.S. Representative Mike Levin (D-CA) toured Sanford Burnham Prebys and met with several faculty members to learn more about the innovative biomedical research taking place in his backyard. Levin represents California’s 49th Congressional District, which includes North County San Diego, South Orange County and neighbors our La Jolla campus.

The visit kicked off with a visit to a lab working to find medicines for a heart arrhythmia condition called atrial fibrillation (AFib), a disorder that hits home for Levin: His grandmother struggled with the disease. Levin peered into a microscope to view beating heart cells and learned how a team of experts from Sanford Burnham Prebys and Scripps Clinic are working to develop personalized treatments for the condition, which affects nearly six million Americans (meet the A-team.)

“Sanford Burnham Prebys is a great example of the vibrant biomedical research taking place in San Diego that has the potential to improve the quality of life for families across the country,” says Levin. “Seeing the Institute’s critical research up close and hearing firsthand how National Institutes of Health (NIH) funding has accelerated medical discovery only strengthens my commitment to supporting biomedical science. Following my visit to Sanford Burnham Prebys, I was proud to introduce legislation that would invest $10 billion in the NIH to support biomedical research, and I will continue to fight for this much-needed funding.”

Following the lab tour, Levin met with faculty members who—thanks to federally funded research—are working to find treatments for Alzheimer’s disease and addiction, and study the aging process to address age-related diseases such as cancer. The visit wrapped up in the lab of Hudson Freeze, PhD, the director of our Human Genetics Program, who studies a rare childhood disease called congenital disorders of glycosylation, or CDG.

“Americans today are living longer and healthier lives because of federally funded medical research,” says Chris Larson, PhD, the adjunct associate professor of Development, Aging and Regeneration at the Institute who arranged the visit. “We are grateful that Mike took the time to sit down with us to learn about our NIH-funded work and how he can help support us on our mission to find cures for human disease.”

Editor’s note: Shortly after his visit Levin introduced legislation that calls for a $10 billion investment in biomedical research.

Institute News

Meet the 2019 Sanford Burnham Prebys graduate student class

AuthorMonica May

Date

September 23, 2019

For nearly fifteen years, Sanford Burnham Prebys has been honored to educate the scientists of the future through our Graduate Program. Today, more than 40 alumni are advancing biomedical research at esteemed institutions around the world.

Who are the scientists who will join this illustrious group of alumni? Read on to learn about our new students and the bold projects they will undertake as part of our 2019 incoming class.

Linda Chang

Hometown: Tainan City, Taiwan
Joins us from: UC San Diego, where she studied skin innate immunity and the host defense mechanism in the Department of Dermatology.
As a PhD student: She will study brain immune cells and molecules that contribute to Alzheimer’s disease, under the guidance of Huaxi Xu, PhD

Zong Ming Chua

Hometown: Singapore
Joins us from: UC San Diego, where he worked on ENCODE, an ambitious project that aims to identify all functional elements in the human and mouse genomes.
As a PhD student: He will focus on better understanding the pathogenesis of the blood cancer acute myeloid leukemia (AML), under the guidance of Peter Adams, PhD

Jordan Friedlein

Hometown: Rockford, Minnesota
Joins us from: California State University, Fresno, where he completed his master’s degree in biology. While a student, he sought to understand how certain cancers become resistant to cell death signaling.
As a PhD student: He will search for vulnerabilities in how cancer cells proliferate and survive in order to develop new targeted therapies, under the guidance of Anindya Bagchi, Ph.D.

Michaela Lynott

Hometown: Alexandria, Virginia
Joins us from: San Diego startup CB Therapeutics, where she produced plant compounds from genetically modified yeast cells.
As a PhD student: She will work to find medicines that boost the heart muscle by mapping novel cardiac pathways and leveraging an automated screening pipeline under the guidance of Alexandre Colas, PhD

Steven Sakuma

Hometown: Shingletown, California
Joins us from: Sanford Burnham Prebys, where he studied the physiological importance of certain pieces of nuclear pore complexes—the gatekeepers to the cell’s nucleus, where DNA lives—in the lab of Maximiliano D’Angelo, PhD
As a PhD student: He will continue his research into the biology of nuclear pore complexes, including their role in aging and disease, under the guidance of D’Angelo.

Benjamin Van Espen

Hometown: Charleroi, Belgium
Joins us from: UC San Diego, where he researched the underlying causes of autoimmune diseases.
As a PhD student: He will research signaling pathways that regulate cellular stress response, under the guidance of Ze’ev Ronai, PhD

For more information about the Sanford Burnham Prebys’ Graduate Program, visit our website.

Institute News

Stepping into a scientist’s shoes at the Cancer Center Open House

AuthorMonica May

Date

June 20, 2019

Cancer research has led to new insights and novel medicines that have transformed the lives of parents, grandparents and children around the world. Yet cancer remains the number-one cause of death in San Diego (nationally, it is the second-leading cause of death). The quest for new and better treatments—and a world free of the disease—remains urgent.

On June 13, 2019, the San Diego community—including many cancer survivors and their loved ones—had a unique opportunity to step into the shoes of a cancer researcher and see how cancer drugs are discovered at the open house of our NCI-designated Cancer Center. The facility is one of only seven National Cancer Institute (NCI)–designated basic research cancer centers in the nation.

Following an introduction by Garth Powis, D. Phil., professor and director of the NCI-designated Cancer Center, guests embarked on guided lab tours. Attendees discovered how we’re working to find better ways to combat cancer, viewed highly specialized equipment—such as machines that model the low-oxygen environment surrounding a tumor—and donned lab coats to catch a glimpse of our ultra-high-throughput drug screening robot in action at our Prebys Center for Drug Discovery. The state-of-the-art technology at the Prebys Center can screen hundreds of thousands of potential drug candidates in one run, accelerating the time it takes to find new, promising compounds that may become tomorrow’s cancer treatments.

Guests also learned how San Diego, with a multitude of world-class research institutes, universities and biotech companies, is shaping the future of cancer diagnosis and treatment. And our Community Advisory Board, comprised of cancer research advocates and cancer survivors, were on hand to share the importance of factoring in patients’ perspectives as breakthrough science moves from “bed to bedside.”

See the science in action in these event photos.

Missed the event? We hope you can join us at our next open house in November. The event is free and open to the public. Check for more details at sbpdiscovery.org/calendar.

Many thanks to our Community Advisory Board (CAB), the host of the open house. Comprised of nine cancer research advocates, including many cancer survivors, this committee strives to create a dialogue between our scientists and the community. We are grateful for CAB’s efforts surrounding the event, which included helping our scientists prepare lay-friendly presentations and posters that were critical to the event’s success.

Interested in keeping up with our latest discoveries, upcoming events and more? Subscribe to our monthly newsletter, Discoveries.

Institute News

Getting groovy for a good cause at Bring It!

AuthorMonica May

Date

May 9, 2019

From the moment guests stepped into the disco-lit room, it was clear Bring It! was not your typical fundraiser.

Donned in bell bottoms, sequined bodysuits and platformed heels, this year’s guests sampled hors d’oeuvre’s supplied by roller-blading servers and grooved to classics such as “Stayin’ Alive” and “Dancing Queen.”

The 70’s-themed event, held on May 2, 2019, at the Del Mar Fairgrounds, drew a crowd of more than 400 attendees—the largest yet—a testament to the hard work and dedication of co-chairs Juli Oh and Matt Browne, and Sarah and David Szekeres. John Weisbarth, host of Tiny House Nation and San Diego native, emceed the event for the third year in a row.

While fun was had by all, the night’s mission was never far from anyone’s mind: fundraising for our Institute’s work to find cures for diseases such as Alzheimer’s, cancer, heart disease, diabetes and more.

Co-chair Sarah Szekeres shared her personal story about why research is important to her: “Learning I have the BRCA2 gene mutation, which puts me at a greater risk of breast and ovarian cancer, has been an overwhelming and frightening experience for me and my family. It’s through basic research that we will develop effective medicines or tests that prevent, diagnose or treat disease—and create a future where my daughter, and her children and grandchildren, aren’t afraid of cancer or Alzheimer’s or the many serious diseases our society faces today.”

Guests vied for an opportunity to participate in onstage competitions—a spot so coveted it was raffled to the highest bidder. Top-scoring teams partook in absurdly hilarious games, such as “Hungry Hungry Human,” where guests attempted to collect plastic balls from an inflated pool while wheeled on a dolly; and “Rocky,” where participants furiously boxed and ran in place to reach the most steps on a pedometer. Despite wearing wigs and hats, contestants even braved a bobbing-for-apples style competition involving candy encased in a Jello Mold.

Altogether, Bring It! certainly puts the “fun” in “fundraising needs.” We hope to see you next year—stay tuned for more details about the date and theme of the event.

We are extremely grateful to the event’s generous sponsors, including Alexandria Realty, Heron Therapeutics, Marleigh and Alan Gleicher, Cooley, Marilena and Greg Lucier, Retrophin, Domain Associates, Robin and Hank Nordhoff, Jeanne Herberger, PhD, Moon Valley Nurseries, Bank of America Merrill Lynch, Luke and Elizabeth Bonacci, Sarah and David Szekeres, Jonell and Gregory Tibbitts, Court and Julie Turner, Dulcy and Mason Matthies, Josie and Jim Myers, Marie Simmons, Arena Pharmaceuticals, BDO, CBRE, Creative Fusion, Cushman & Wakefield, IDT, Deloittte & Touche, Farrell Family Foundation, iProtean, KPMG, Johnson & Johnson, Marsh & McLennan Agency, Neurocrine Biosciences, Oxford Finance, Pegasus Building Services, UnionBank, Cabrillo Advisors, Square1bank and USI Insurance Services.

Watch a fun-filled KUSI segment about the event.

Head to our Facebook page to view event photos; search #BringIt19 to find more content.

Interested in keeping up with our latest discoveries, upcoming events and more? Subscribe to our monthly newsletter, Discoveries.

Institute News

Inspiring future scientists at the STEM EXPO

AuthorMonica May

Date

March 25, 2019

Armed with wiggly worms and striped zebrafish, on Saturday, March 2, more than 20 volunteers from Sanford Burnham Prebys helped kids and their families learn about the power of DNA at the San Diego Festival of Science & Engineering’s EXPO Day.

One of the largest STEM (Science, Technology, Engineering and Math) festivals in the U.S., this year’s event featured more than 130 interactive exhibits designed to ignite a passion for science in K–12 students. Despite an uncharacteristically rainy morning, an estimated 17,000 people attended.

For Joseph Lancman, PhD, a postdoctoral researcher at our Institute who was the first in his family to graduate from college, the festival was an opportunity to provide children with the experience he wishes he’d had as a kid.

“Growing up, I knew I was interested in human health, but I had no idea that research was an option,” Lancman says. “Like many kids, I thought I wanted to be a doctor. But in college, I quickly learned that I wanted to know more. I wanted to know what causes disease and how scientists go about finding cures.”

STEM EXPO 2019 Joseph Lancman and son — Dr. Lancman and his son

At our booth, postdoctoral researchers, graduate students and staff helped children don paper lab coats and explore DNA-themed activities.

Children were able to see live worms with DNA mutations that affect their movement, courtesy of the lab of Malene Hansen, PhD, professor in the Development, Aging and Regeneration Program. Compared to normal worms, some mutant worms moved mindlessly in circles, and others remained relatively immobile—illustrating how changes in a DNA sequence can dramatically affect life.

At the adjacent station, provided by the lab of Duc Dong, PhD, assistant professor in the Human Genetics Program, children squinted through microscopes and peered into fish tanks to observe how DNA changes can dramatically affect the heartbeat of zebra fish—one of the most powerful model organisms used to study vertebrate biology.

Lancman, who works in Dong’s lab, took care to explain the exhibit in child-friendly language (he credits his four-year-old son for helping him develop this skill).

“I want kids to know that science is like a puzzle,” he explains. “It takes time to put all the pieces together, but when you’re done, you can see the big picture—and that big picture can lead to improving human health.”

Institute News

5 takeaways from Insights: Heart Disease

AuthorMonica May

Date

February 15, 2019

It’s easy to forget about the fist-sized organ in our chest. But the heart is arguably the most important muscle in the body. We can’t live without it, after all.

To help educate the public about heart health and share the latest scientific advances, this month Sanford Burnham Prebys Medical Discovery Institute (SBP) invited the San Diego community to a free panel discussion focused on the heart.

More than 70 community members attended the event, whose speakers included cardiologist Anthony N. DeMaria, MD; Jack White, chair in Cardiology, professor of Medicine, founding director, Sulpizio Cardiovascular Center at UC San Diego Health; Donna Marie Robinson, an individual living with heart failure; and heart researcher Karen Ocorr, PhD, assistant professor, Development, Aging and Regeneration Program at SBP. Jennifer Sobotka, executive director at the American Heart Association San Diego, moderated the discussion.

In a special introduction provided by Rolf Bodmer, PhD, director and professor in the Development, Aging and Regeneration Program at SBP, he explained that his heart research uses model organisms such as the fruit fly. He quipped, “Which some of you didn’t even know had a heart.”

The ensuing discussion was robust and insightful. Below are five important takeaways:

Heart disease is the number-one killer of Americans. Nearly half of American adults have some form of heart or blood vessel disease.
Obesity is an epidemic in America. In the 1960s, approximately 13 percent of American adults were obese, according to the Centers for Disease Control (CDC). Today, that number has tripled to nearly 40 percent. DeMaria illustrated this point with a colored map showing obesity’s prevalence during each decade, which drew gasps from the crowd.
Know your numbers. Donna Marie was healthy and fit, so she didn’t think that a fainting episode could have been heart disease. “My cardiologist saved my life,” she said. Now, she encourages everyone to “know your numbers, including your cholesterol level and your blood pressure.”
Rethink swatting that pesky fruit fly. We share 80 percent of disease-causing genes with the tiny insect, including ion channels that keep the heart pumping. For this reason scientists are studying fruit-fly hearts in an effort to learn about the many mysteries of the heart, such as how the rhythm disorder atrial fibrillation (AFib) arises.
Consider moving to Italy. Just about everyone wants to know which science-backed diet to follow for optimal health. DeMaria explained that the most robust data supports eating a Mediterranean diet rich in fruits, vegetables and olive oil.

Read the La Jolla Light’s coverage of the event.

Institute News

Padres Pedal the Cause presents record-breaking check for nearly $3 million to fund local cancer research

AuthorMonica May

Date

January 29, 2019

Local cancer research just got a big boost.

On Thursday, January 24, SBP president Kristiina Vuori, MD, PhD, joined leaders from Moores Cancer Center at UC San Diego Health, Salk Institute for Biological Studies and Rady Children’s Hospital–San Diego to help Padres Pedal the Cause (PPTC) reveal that this year’s event raised a record-breaking $2.9 million for local cancer research. The leaders joined executive director Anne Marbarger onstage to receive the official check.

This year’s event—which invited participates to cycle, spin, run or walk—had more than 2,500 participants, an increase of 35 percent. Total fundraising grew by 22 percent. SBP has participated in the event since its inception; and this year our team of more than 60 scientists, staff and SBP supporters raised more than $30,000 for the cause. Since the inaugural ride six years ago, PPTC has raised more than $10 million.

Nearly 300 of the event’s participants, including Tony Gwynn Jr., Pedal founders Bill and Amy Koman, San Diego business leaders, and top donors and fundraisers, gathered at the Del Mar racetrack to witness the funding reveal and check presentation in person.

Gwynn shared a moving story about his father’s battle with salivary cancer, a journey he still finds difficult to recount. “If he saw this progress, he would be smiling today,” he said.

A full 100 percent of the proceeds fund collaborative research taking place at the four San Diego research institutes. Past PPTC grants have accelerated SBP’s research into cancers of the breast, skin, brain, colon, pancreas and more. This year’s grant announcement will be revealed in the spring.

In the meantime, make sure to mark your calendars for the 2019 event, which will take place on Saturday, November 16. Registration will open in mid-April.

Interested in keeping up with SBP’s latest discoveries, upcoming events and more? Subscribe to our monthly newsletter, Discoveries.

Institute News

Highlights from the 2018 Faculty Retreat

AuthorSusan Gammon

Date

June 4, 2018

SBP’s annual Faculty Retreat was held May 30–31 in beautiful Carlsbad, California.

This year’s theme was “Fundamental Cellular Processes in Health and Disease,” and featured 20 speakers from SBP areas of expertise:

· Development and Aging — Malene Hansen, PhD, Lorenzo Puri, MD, PhD, Karen Ocorr, PhD, Alexey Terskikh, PhD, and Rolf Bodmer, PhD

· Immunity and Inflammation — Rob Weschler-Reya, PhD, Linda Bradley, PhD, Scott Peterson, PhD, and Jeff Smith, PhD

· Technology Platforms — Dorit Hanein, PhD, Sumit Chanda, PhD, and Niels Volkmann, PhD

· Drug and Disease Targets — Michael Jackson, PhD, Garth Powis, PhD, Wanda Reynolds, PhD, Elena Pasquale, PhD, and Matt Peroski, PhD

· Share Resources Update — Craig Hauser, PhD

Special congratulations to Duc Dong, PhD, and Crystal Zhao, PhD, both of whom were officially promoted to associate professors.

Faculty promotion — Pictured (left to right): Duc Dong, PhD, Elena Pasquale, PhD and Crystal Zhao PhD

Dong, in the Human Genetics Program, is advancing research in cell/organ replacement therapy that may ultimately benefit patients with diabetes and Alagille syndrome—a genetic disorder that can affect the liver, heart and other parts of the body.

Zhao, in the Tumor Initiation and Maintenance Program, is studying the regulation of neural stem cells—research that may lead to therapies for neurological diseases, including Alzheimer’s disease, Parkinson’s disease, and mental health disorders that affect cognitive abilities.

A highlight of the annual retreat is the presentation of the “WOW” award, which stands for Wonderful Original Work. This year, the WOW was given to Robert Wechsler-Reya, PhD, who won for his presentation titled “Overcoming Immune Evasion in Pediatric Brain Tumors.”

Wechsler-Reya’s research goal is to advance immunotherapy for medulloblastoma tumors—the most common malignant brain tumor in children. By increasing certain cell surface molecules called MHC on these cancer cells, he believes he can improve the ability of T cells to recognize the tumors and kill them.

Wechsler-Reya is a professor in the Tumor Initiation and Maintenance Program at SBP and is also the program director for the Joseph Clayes III Research Center for Neuro-Oncology and Genomics at Rady Children’s Institute for Genomic Medicine.

Cosimo Commisso, PhD, and Crystal Zhao, PhD, served as faculty organizers.

And many thanks to Wendy Lyon and Nelson, the research administrative specialists who organized the event.

Institute News

SBP brings science to San Diego community at STEM

AuthorSusan Gammon

Date

March 8, 2018

STEM Expo Day kicked off a week-long festival on Saturday, March 3, 2018 at Petco Park. The event marked the 10th annual San Diego Festival of Science and Engineering Expo Day—one of the largest STEM (Science, Technology, Engineering and Math) festivals in the U.S. The community outreach event provided learning and hands-on activities for students in grades kindergarten through 12th grade, as well as adults and families to ignite their passion for STEM education.

“STEM Expo is a great way to get our future researchers excited about science, and I believe that’s why SBP’s involvement continues to expand,” said Karen Ocorr, PhD, an SBP faculty member who organized a research demonstration for the exhibit booth.

About 40 SBP volunteers, including faculty, postdocs, staff and graduate students, worked in three shifts throughout the day to talk with visitors and guide them through two sets of interactive programs.

Ocorr set up a station where children received paper lab coats with personalized name tags to explore the food preferences of fruit flies and how it affects their heart health. Visitors used microscopes and high-powered LED magnifying glasses to look at fly abdomens to see if they had eaten sugar (dyed red) or fat (dyed blue). Not surprisingly, the fruit flies prefer a high sugar diet. Ocorr shared videos of beating fly hearts showing that both high sugar and high fat are bad for heart function.

The second station gave visitors an opportunity to interact with models of drugs and human proteins made by a 3D printer, courtesy of Adam Godzik, PhD, director of the Bioinformatics and Structural Biology Program at SBB. Godzik’s lab also brought glasses for viewing a virtual reality program showing how protein folding configurations are used to design drugs.

The event, which was free and open to the public, had more than 130 interactive exhibits with hands-on learning activities.

In spite of rain an estimated 25,000 people participated in EXPO Day at Petco Park.

Institute News

Remembering Dongxian Zhang

AuthorKristen Cusato

Date

March 31, 2017

Dongxian Zhang, PhD, our valued colleague, collaborator, mentor and friend, recently passed away after a long illness.

Dongxian had been with SBP since the fall of 1999. He came to us from Harvard Medical School. “He was a valued associate professor in our Degenerative Diseases Program and served as an adjunct assistant professor in the Department of Molecular Pathology at UC San Diego since 2004,” says Kristiina Vuori, MD, PhD, president of SBP. “His positive and helpful personality will be missed and always remembered.”

“He told me he was surprised that he had been accepted to college, but that acceptance motivated him to go on to make major contributions to his chosen field of study,” says Randal Kaufman PhD, director of the Degenerative Diseases Program.

“When Dongxian shared the news about his diagnosis, he was incredibly brave and at peace with his life,” says Kaufman. “I will truly miss my friend. I will also miss the times we played golf. We enjoyed the camaraderie, which I will never forget.”

Dongxian made key advances in the study of motor neuron degeneration, including the discovery of novel neuroprotective factors and biomarkers of early events in disease pathology. Recent findings in collaboration with Huaxi Xu, PhD, professor at SBP, should be published soon and may lead to new diagnoses and treatments for motor neuron diseases.

Xu says he will remember his friend for his gentle demeanor and extreme dedication to his trainees. “Dongxian would never hesitate to jump into the lab to finish an experiment, calibrate instruments or perform molecular biology to help out members of his lab, as well as our lab,” Xu says. “His illness came as a surprise to everyone. He faced his sickness with great integrity and humor.”

“To me, he was more than a mentor for my work but also to my life,” says Lu-Lin Jiang, PhD, who worked in Dongxian’s lab. “He gave us much freedom to explore the beauty of the science. He took care of us like he took care of his own kids. When he was recovering from his first brain surgery, he told us he was not afraid of death, but he was worried about us. Later, he tried to help us to find new positions. Dongxian was the most positive person I have ever met.”

Dongxian leaves behind his wife Dong-Er Zhang and two sons, David and Phillip. We offer our sincere condolences to his family.

More about Dongxian Zhang

In 1969, during the Culture Revolution in China, Dongxian, like many students in big cities, was sent from Shanghai to a rural village to be “re-educated” by farmers. He was only 16 years old and had completed less than one year of middle school. When the Revolution ended in 1977, the Chinese government reopened enrollment for college entrance and Dongxian took the national college entrance exam. Using textbooks he borrowed from the headquarters of a local railroad, he taught himself enough middle and high school subjects to receive one of the top 10 exam scores in Yunnan province in 1978. He went on to study at Peking University, one of the most prestigious in China.

Dongxian was hoping to write a novel based on his life experience, but sadly this never happened.

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Meet the 2019 Sanford Burnham Prebys graduate student class

Stepping into a scientist’s shoes at the Cancer Center Open House

Getting groovy for a good cause at Bring It!

Inspiring future scientists at the STEM EXPO

5 takeaways from Insights: Heart Disease

Padres Pedal the Cause presents record-breaking check for nearly $3 million to fund local cancer research

Highlights from the 2018 Faculty Retreat

SBP brings science to San Diego community at STEM

Remembering Dongxian Zhang

More about Dongxian Zhang