Graduate School of Biomedical Sciences Archives - Page 3 of 4 - Sanford Burnham Prebys
Institute News

Meet computational biologist Mallika Iyer

AuthorMonica May
Date

January 14, 2021

Iyer is studying how proteins “dance,” which could lead to better drugs and a deeper understanding of human health 

DNA is often the star of the show when we talk about the body, but proteins are the true front-line workers. Formed by DNA’s instructions, proteins begin as strings of chemical compounds and later fold into a 3D shape that dictates their job in the body. If scientists can solve a protein’s shape—a feat that often takes years or decades—they may be able to create better drugs or better understand disease.  

Biologist Mallika Iyer, a graduate student in the Godzik lab at Sanford Burnham Prebys, is harnessing the power of computers to unlock insights into protein structure and movement. We caught up with Iyer as she prepares to take the virtual stage at DASL (the Diversity and Science Lecture Series at UC San Diego) to learn more about her greatest hopes for her research and what makes her tick.

Did you always know you wanted to be a scientist?
I’ve known I wanted to be a scientist ever since I learned about the digestive system as a kid. I was fascinated by how the human body works—it’s the most well-thought-out machine ever. 

I didn’t, however, imagine myself being a computational scientist until much later. When I was in college, I realized that traditional lab work wasn’t for me. I began learning some basic coding after I graduated and was hooked. That transitioned into computational biology/bioinformatics.

What do you study, and what is your greatest hope for your research?
I study protein structure and flexibility. Proteins are often depicted as having a single structure, but they are actually very flexible and transition between many different conformations as a part of their function—sort of like a well-choreographed dance.

My greatest hope for my research, or this field in general, is that we will someday be able to predict the types of movements a protein undergoes during the course of its function, or “job.” Last year, the field saw a huge advancement in the prediction of protein structure (read more in The New York Times). But “structure” is only half the story. Being able to predict all the different conformations and movements would be incredibly useful for medicine—and very cool!

What do you wish people knew about science?
That being wrong is a huge part of science. Scientists are supposed to understand and explain how the world works. But that is something that involves a lot of trial and error! Being wrong is, in fact, the way we advance our knowledge.

When you aren’t working, where can you be found? Where is your happy place?
Prior to the pandemic, my happy place was actually the climbing gym. I was introduced to indoor rock climbing about two years ago, and I instantly fell in love it with. It’s a great way to exercise both your body and mind, and I have found the climbing community to be really friendly and accepting. What makes my gym even better is that it also has extra space to just hang out, work, read a book, and so on. So, I used to go there a lot!

What is the best career advice you have ever received? 
Use every opportunity you can to present your work and network with people. I try to present at as many conferences and symposia as I can, and simultaneously use that as a way to meet and network with others in the field. I’ve found that this allows me to practice answering questions about my work, which in turn enables me to think more critically about it. And it can also lead to new opportunities that further my research and career.

What do you wish people knew about Sanford Burnham Prebys?
That it has a graduate program! I think our program is really unique. Its small size means that each student gets a lot of attention, and we have an Office of Education, Training and International Services (OETIS) that really offers us a lot of great resources to help us shape our careers.
 

A woman in workout clothes kneeling in front of a rock climbing wall

​Prior to the pandemic, Mallika’s happy place was the climbing gym. “It’s a great way to exercise both your body and mind, and I have found the climbing community to be really friendly and accepting,” she says.

Learn more about the Institute’s Graduate School of Biomedical Sciences.

Institute News

Meet the new graduate student class at Sanford Burnham Prebys

AuthorMonica May
Date

October 20, 2020

Get to know the biomedical researchers of the future

Although Sanford Burnham Prebys has spent more than four decades fostering a reputation for excellence in basic biomedical research, our Graduate School of Biomedical Sciences is relatively young. Founded in 2005, the program’s mission is to educate and train students to become the innovative biomedical scientists of the future.

“This year’s group of graduate students will work on ambitious projects that will help us learn about the biology of aging, the origins of cancer and more,” says Guy Salvesen, PhD, dean of the Graduate School of Biomedical Sciences. “I look forward to seeing what these talented individuals will accomplish in the coming years under the guidance of our dedicated faculty.”

Meet this year’s incoming class of graduate students and learn about the bold projects they will undertake while at the Institute—and what drives them personally.

Sviatlana Zaretski (Hansen lab)

Sviatlana Zaretski began interning in the lab of Malene Hansen, PhD, as an undergraduate at University of California, San Diego. This led to a lifelong fascination with autophagy, a cellular recycling process that plays an important role in aging—the single greatest risk factor for diseases such as Alzheimer’s, cancer and diabetes.

After graduation, Zaretski continued this work as a research assistant in the lab. Now, as a graduate student, she will build upon the knowledge she has gained to date to decipher the molecular changes that occur during aging and how they alter autophagy. This work could unlock new ways to slow the aging process and promote healthy aging.

Sviatlana Zaretski

“When I’m not in the lab, I can be found on the beach or in the park with my family.”

Rema Iyer (Deshpande lab)

Rema Iyer joins the graduate program with more than a decade of experience working in the pharmaceutical and biotechnology industries—including roles at Eli Lilly, Takeda Pharmaceuticals, GNF and AnaptysBio. Across these positions, her focus remained on preclinical drug discovery and drug engineering—with the goal of ensuring medicines are safe and effective in the human body.

As a graduate student in Ani Deshpande’s lab, Iyer will work to understand the role of epigenetics—chemical tags placed on DNA that alter gene expression—in cancers like acute myeloid leukemia. Her hope is that this work will lead to therapies that are meaningful to people with these cancers.

Rema Iyer

“What I love most about research is that I get to use my passion for science to help people. And with a PhD, I can have even more impact.”

Utkarsha Paithane (Bagchi lab)

Utkarsha Paithane obtained an integrated bachelor’s and master’s degree in biotechnology from Amity University in India. She then went on to obtain a master’s degree at Keck Graduate Institute in California, where she worked to determine how non-small-cell lung cancer develops resistance to a targeted treatment called erlotinib.

As a graduate student in the lab of Anindya Bagchi, PhD, Paithane will work to uncover genetic mutations that contribute to cancer initiation, which could lead to treatments that prevent cancers from developing.

Utkarsha Paithane

“One of my favorite moments in my life is when my first DNA experiment in my undergrad worked. I was so proud!”

Adarsh Rajesh (Adams lab)

Adarsh Rajesh first connected with Sanford Burnham Prebys when he worked as an assistant in the lab of Peter Adams, PhD, studying cellular senescence, a sleeplike state of aged cells. Now, as a graduate student in the Adams lab, Rajesh will investigate the impact of epigenetics—chemical tags placed on DNA that alter gene expression—on cellular senescence, aging and cancer.

Rajesh is interested in combining bioinformatics techniques and cell biology to unlock the cellular mechanisms that drive aging and age-associated diseases—which could lead to treatments that promote healthy aging or prevent age-associated diseases.

Adarsh Rajesh

Rajesh is interested in combining bioinformatics and cell biology to understand aging.

Cedomir (Ceda) Stamenkovic (Sacco lab)

Ceda Stamenkovic completed his undergraduate studies at University of California, San Diego, where he majored in neuroscience and physiology. After graduation, he worked in several neuroscience research labs studying the brain’s response to opioids and reward behavior.

As a graduate student in the lab of Alessandra Sacco, PhD, Stamenkovic shifts his focus to muscle stem cells and how they degrade due to natural aging or muscular dystrophy. This work could lead to muscle-boosting treatments that help people maintain muscle mass as they age, or help people living with muscular dystrophy.

Cedomir (Ceda) Stamenkovic

“I’ve always been fascinated by the living world. I was interested in both biology as well as ecology, but I chose biology because of its ability to advance health and medicine. That’s very important to me.”

Institute News

Meet neuroscientist Paloma Sánchez Pavón

AuthorMonica May
Date

October 7, 2020

Paloma’s research aims to protect premature babies from brain damage

Newborns have a new scientist in their corner: Paloma Sánchez Pavón, a graduate student in the lab of Jerold Chun, MD, PhD Paloma is working to find a medicine that could protect the still-developing brains of premature babies, which are incredibly delicate and prone to swelling. Called hydrocephalus, the condition is common—affecting one in 1,000 newborns—and repeated brain surgery is the only treatment.

We caught up with Paloma to learn more about what makes her tick, including why she decided to become a scientist and what she wishes people knew about research.

  • Did you always know you wanted to be a scientist? When you were a child, did you ever imagine you would be in the role you are today?
    I always knew I wanted to become a scientist, but I didn’t imagine I would be in the position I am today. Growing up, I was obsessed with the idea of becoming a marine biologist. I was fascinated by how much we didn’t know about the ocean. My plan was to move closer to the beach and enroll in a program that would allow me to learn more about it. Nevertheless, I soon realized that I was both mesmerized and terrified of the ocean (sharks, especially), and that I would never be able to spend enough time diving and exploring the water, which is what such a career would require. I was still passionate about biology and science in general, so I decided to study the most unknown (and equally unexplored) organ in the human body—the brain.
  • What do you study, and what is your greatest hope for your research?

    I study hydrocephalus, a condition that often affects premature infants. These newborns are extremely fragile and often accumulate fluid in their heads, which can cause brain damage or death. The only treatment is invasive brain surgery, required multiple times throughout individuals’ lives, to insert a shunt in their brains and drain the excess fluid so it is reabsorbed somewhere else in the body. This procedure is extremely uncomfortable for the patients and, like any other surgery, is associated with several risks that endanger their lives. I’m trying to understand the disease so we can find a better, less invasive treatment.

Paloma Sánchez Pavón at the beach in front of the ocean at sunset

When Paloma isn’t working in the lab, she can be found enjoying one of San Diego’s many beautiful beaches

  • What is one scientific question you wish you had an absolutely true answer to?
    To answer this question, I will step away from biology and turn to the universe. What is there beyond our galaxy? Will we be able to inhabit other planets? If we have so many things to still learn about the ocean and the brain, the universe is in a completely different category, with so many possibilities ahead of us.
  • What do you wish people knew about science?
    That it is fun. Experiments are about testing limits and going beyond what is known. I think that is really exciting. Also, science advances because we’re constantly asking new questions. Curiosity is what keeps this field in continuous evolution. And never be afraid to ask questions because science can be understood by everybody—it just needs to be explained well.
  • When you aren’t working in the lab, where can you be found? Where is your happy place?
    You will find me at the beach, walking along it or watching a sunset. One of the main reasons why I decided to move to San Diego is because I fell in love with its sunsets. You will also find me having brunch (my favorite American tradition) with my friends or enjoying a beer after work with them, especially around Encinitas or downtown San Diego.
  • What is the best career advice you have ever received?
    Never stop pushing the boundaries of knowledge. A curious mind is what keeps a scientist passionate about their job. Experiments usually don’t work the first time. You have to keep asking new questions and learning from your mistakes. Finishing a project takes time, but every day is unexpected and exciting because you don’t know what you’re going to find. That is the thrilling part about being a scientist.
  • What do you wish people knew about Sanford Burnham Prebys?
    What a great community Sanford Burnham Prebys is. I’ve never been in such a collaborative environment, where you work closely not only with students and postdocs, but also with faculty members. Everyone is always willing to help, whether that is lending reagents or advising about different techniques. As a student, this is what I value the most because it helps me develop as a scientist in an extremely enriching way.

Learn more about our Graduate School of Biomedical Sciences.

Institute News

19th annual Trainee Research Symposium is a virtual success!

AuthorSusan Gammon
Date

October 5, 2020

Sanford Burnham Prebys’ annual Trainee Research Symposium is dedicated to highlighting the research of postdoctoral scientists and advanced graduate students.

This year, nearly 40 early-career scientists presented their research during an engaging two-day, jam-packed Zoom call that went off without a hitch.

After opening remarks by Malene Hansen, PhD, professor and faculty adviser for Postdoctoral Training, the podium and poster presentations began. Faculty, trainees, staff scientists and other interested parties navigated through sessions that ranged from new approaches to conquer brain cancer to the molecular basis of aging. The event gives “up-and-coming” scientists an opportunity to receive feedback on their work, explore potential new collaborations and receive prize money to support career development activities.

“We’re fortunate to be starting our careers at Sanford Burnham Prebys where the scientific research is significant and diverse,” says Cynthia Lebeaupin, PhD, a best poster presentation award winner. “I’m grateful to be able to present my project, which is focused on the link between fatty liver disease and cancer, to colleagues from different disciplines, such as cardiac disease and immunology. Their questions about my research bring fresh perspectives and spark new ideas.”

Keynote speaker Martin Chalfie, PhD, a Nobel Laureate in Chemistry and professor at Columbia University, opened day two of the event with a presentation titled, “GFP: Lighting Up Life,” detailing the journey that led to his discovery of GFP—a fluorescent protein that revolutionized how scientists look at the inner workings of living cells. Chalfie followed with an informal “Ask Me Anything” session where he shared his passion for mentoring early-career scientists.

C. Randal (Randy) Mills, PhD, CEO of Sanford Burnham Prebys, closed the event with a happy hour exclusively attended by trainee presenters—an opportunity for everyone to get to know more about his experiences as a PhD student and how his career evolved to his current position as leader of our world-class biomedical research Institute.

Many congratulations to all who participated in the symposium, and thanks to the organizers at the SBP Science Network and the Office of Education, Training, & International Services (OETIS).

This year’s symposium winners are:

Best Podium Talk – Judges Selection

Natalie Kirkland, PhD
Engler/Bodmer Labs
Runner-up
Stephen Sakuma
D’Angelo Lab

Honorable Mentions

Mallika Iyer
Godzik Lab
Jaime Zlamal, PhD
Osterman Lab

Best Poster –Judges Selection

Cynthia Lebeaupin, PhD
Kaufman Lab
Rashmi Mishra, PhD
Dong Lab
Ee Phie Tan, PhD
Hansen Lab

Best Podium Talk – Popular Vote

Stephen Sakuma
D’Angelo Lab

Honorable Mention

Jaime Zlamal, PhD
Osterman Lab

Institute News

A path to parity for Black PhD students in the sciences

AuthorMonica May
Date

August 18, 2020

Graduate school dean Guy Salvesen describes barriers he has seen for students who are Black and how we can make science fully inclusive.

Only 5% of graduate students in science and engineering are Black despite making up more than 13% of the U.S. population—and in spite of showing similar levels of interest in science as their peers. A PhD is required for career advancement in biomedical research—so this disparity impacts the number of faculty members, CEOs and scientific leaders who are Black. It will take persistent and bold efforts on the part of individuals, groups, institutions and society at large if we are to achieve anything close to equality.

To learn more about this topic, we spoke with Guy Salvesen, PhD, professor and dean of the Graduate School of Biomedical Sciences at Sanford Burnham Prebys about barriers that discourage students who are Black from applying to PhD programs—and how they can be dismantled to address disparities.

Why are you personally passionate about achieving racial equality in the biomedical sciences?
Standing up for equality has always been a big part of my family’s values. I was born in South Africa during the era of apartheid. My mother always made it clear that she detested racism and the people who defended it. Before we moved away, she was part of a resistance organization called the Black Sash—a woman’s-only movement against apartheid. I come from a single-parent household, so my mother had an especially big influence on me.

Do you receive a lot of applications from PhD students who are Black?
We receive many applications from Latinx students, but I have to say not as many from Black students. We know this is not due to lack of interest. There are systemic barriers at play, which as a graduate school we try to address to the best of our abilities. Our founding mission was to have a student population that mirrors California’s demographics, so we are committed to doing all we can to reach that goal.

Guy Salvesen, PhD, dean, Graduate School of Biomedical Sciences

Guy Salvesen, PhD, is the dean of the Graduate School of Biomedical Sciences at Sanford Burnham Prebys.

In your experience, what are the barriers that prevent students who are Black from applying to PhD programs?
First, I believe the biggest hurdle is the monetary aspect of a career in science. The field is poorly rewarded financially, especially compared to a career such as pharmacy or medicine. You must commit to almost a decade of minimum-wage pay as you complete graduate-school and then postdoctoral studies. Scientists are some of the most highly trained individuals in the world—and for many years, they are paid close to minimum wage.

Even when you complete training and find a well-paying job, many students have educational loans to pay back—and Black students are more likely to have loans because of the racial wealth gap. The students who apply but don’t attend our graduate school typically accept positions in pharmacy, where they can more rapidly start earning a high salary. To pursue biomedical research as a career, you have to be incredibly passionate about science and be able to defer economic rewards. I wish it wasn’t like that, but that’s the reality.

I believe it’s important to get students excited about science early and sustain that enthusiasm. Once a student begins a PhD program, they are hooked. We need to make sure that kids who are Black are getting early, positive experiences with science. This can be accomplished through school or after-school programs. This also helps children see themselves as scientists—and that’s an incredibly important factor as students consider their future careers.

What solutions could overcome these barriers?
Ideally, the National Institutes of Health would allocate funds to pay graduate students and postdocs better wages. This is also an area where philanthropy can play a big role. At Sanford Burnham Prebys, we are always grateful to the Fishman Fund Awards, which supplement the salaries of select postdocs. In a perfect world, we would be able to pay better wages to all graduate students and postdocs. Also, any actions that decrease student loan debt would help free students to choose science as a viable career option.

We need to ensure that we are proactively reaching out to schools that are serving students who are Black, especially Historically Black Colleges and Universities which award up to 30% of Black STEM PhDs; providing a safe and welcoming environment for graduate students who are Black; educating our Institute and especially faculty mentors about how to best support students from different racial backgrounds; and hiring faculty members who are Black. We also need to continue to listen and learn about additional actions we can take to achieve racial parity in our program.

Could you share some examples of actions the graduate school took that had particular success?
A partnership we have with the Preuss School, a middle and high school for students who would become the first in their families to graduate from college, has been very successful. Preuss students spend time in our Institute’s labs during the summer and experience what it’s like to work side by side with scientists. We also try to bring parents into the mix by inviting them to our campus, because they have a tremendous influence on the careers their children pursue. Many of our Preuss students went on to select STEM majors in college. Right now, we are short on funds to continue this program. We need support to keep it going.

We also liaise with California state colleges that serve members of underrepresented groups, such as the California State University campuses in Fresno, Long Beach and nearby San Marcos. Through summer internship programs, students from these schools experience advanced laboratory research for the first time. Once these students realize how much fun it is do science in a state-of-the-art facility, they get very excited.

Where do we go from here? Are you hopeful about the future?
It gives me hope that there is movement in society to redress wrongs that have occurred for more than 400 years. I’m optimistic that societal pressures will translate to real action. These issues are not new. It’s time that we listen, learn and take action. And that’s on all of us. No one is immune from systemic racism, and each of us has a role we can play to make positive change.

If you have any questions, comments or would like to share follow-up resources, contact us at info@sbpdiscovery.org.

Dr. Salvesen’s suggested readings:

Institute News

Meet the 2019 Sanford Burnham Prebys graduate student class

AuthorMonica May
Date

September 23, 2019

For nearly fifteen years, Sanford Burnham Prebys has been honored to educate the scientists of the future through our Graduate Program. Today, more than 40 alumni are advancing biomedical research at esteemed institutions around the world.

Who are the scientists who will join this illustrious group of alumni? Read on to learn about our new students and the bold projects they will undertake as part of our 2019 incoming class.

Linda Chang

  • Hometown: Tainan City, Taiwan
  • Joins us from: UC San Diego, where she studied skin innate immunity and the host defense mechanism in the Department of Dermatology.
  • As a PhD student: She will study brain immune cells and molecules that contribute to Alzheimer’s disease, under the guidance of Huaxi Xu, PhD
Graduate Student Linda Chang

Zong Ming Chua

  • Hometown: Singapore
  • Joins us from: UC San Diego, where he worked on ENCODE, an ambitious project that aims to identify all functional elements in the human and mouse genomes.
  • As a PhD student: He will focus on better understanding the pathogenesis of the blood cancer acute myeloid leukemia (AML), under the guidance of Peter Adams, PhD
Graduate Student Zong Ming Chua

Jordan Friedlein

  • Hometown: Rockford, Minnesota
  • Joins us from: California State University, Fresno, where he completed his master’s degree in biology. While a student, he sought to understand how certain cancers become resistant to cell death signaling.
  • As a PhD student: He will search for vulnerabilities in how cancer cells proliferate and survive in order to develop new targeted therapies, under the guidance of Anindya Bagchi, Ph.D.
Graduate Student Jordan Friedlein

Michaela Lynott

  • Hometown: Alexandria, Virginia
  • Joins us from: San Diego startup CB Therapeutics, where she produced plant compounds from genetically modified yeast cells.
  • As a PhD student: She will work to find medicines that boost the heart muscle by mapping novel cardiac pathways and leveraging an automated screening pipeline under the guidance of Alexandre Colas, PhD
     
Graduate Student Michaela Lynott

Steven Sakuma

  • Hometown: Shingletown, California
  • Joins us from: Sanford Burnham Prebys, where he studied the physiological importance of certain pieces of nuclear pore complexes—the gatekeepers to the cell’s nucleus, where DNA lives—in the lab of Maximiliano D’Angelo, PhD
  • As a PhD student: He will continue his research into the biology of nuclear pore complexes, including their role in aging and disease, under the guidance of D’Angelo.
Graduate Student Steven Sakuma

Benjamin Van Espen

  • Hometown: Charleroi, Belgium
  • Joins us from: UC San Diego, where he researched the underlying causes of autoimmune diseases.
  • As a PhD student: He will research signaling pathways that regulate cellular stress response, under the guidance of Ze’ev Ronai, PhD
Graduate Student Benjamin Van Espen

For more information about the Sanford Burnham Prebys’ Graduate Program, visit our website.

Institute News

Meet Clyde Campbell: A new PhD graduate

AuthorMonica May
Date

June 17, 2019

When Clyde Campbell was 6 years old, his life changed overnight. 

“I went to sleep, and everything was completely normal. But when I woke up, my knee had swollen to three times its usual size and was stuck in a 90-degree position. I learned I had juvenile rheumatoid arthritis, which then spread throughout my body—and no one knew why this had happened.”

Like the adult form, juvenile rheumatoid arthritis occurs when the immune system attacks healthy tissue. But much remains unknown—including the initial trigger that causes the body to misfire—and treatments are limited. This mystery sparked Campbell’s interest in science and desire to understand the ‘why’ behind disease—and thus create better medicines.

After obtaining a bachelor’s degree in molecular biology from UC San Diego, Campbell applied to Sanford Burnham Prebys’ Graduate School in hopes of working with his scientific hero, Duc Dong, PhD, assistant professor in the Human Genetics Program. 
 
“When I completed my work at UC San Diego, everyone spoke highly of Dr. Dong and the thoroughness of his science. I knew very early on that I wanted to work with him,” says Campbell. “Sanford Burnham Prebys’ graduate school was attractive to me because the program allows you to start working with your PhD advisor right away—so I met with Dr. Dong and began my research.”   

Last month, Campbell completed his doctorate, the 40th PhD awarded by the Graduate School.  His thesis, completed under Dong’s guidance, demonstrated his success in reprogramming developing cells within a zebrafish (mesoderm- and ectoderm-derived cells) into the cells that become the pancreas (pancreatic progenitors), an important advance for people with type 1 diabetes (insulin is released from cells in the pancreas). Current cell-based treatments rely upon cadaver-sourced cells, which are effective but are unable to meet patient demand.

Campbell will carry his training and knowledge of cellular differentiation to Iowa State University, where he’s accepted a position as an adjunct associate professor. There, he will continue his regenerative medicine work, with a new focus on blood cell differentiation. This work could lead to treatments for children with leukemia and people battling other blood disorders. As a father to a 3-year-old daughter, his research now takes on special meaning.

“As a society, one of the most important things we can do for future generations is impart new knowledge. With research comes powerful insights—which could lead to cures. One day, I hope no child or adult will have to go through my experience.” 

Learn about Sanford Burnham Prebys’ Graduate School. 

Check out our upcoming SBP Insights event, held on June 20, 2019, which features a doctor, scientist and patient discussing rheumatoid arthritis and other autoimmune diseases.

Interested in keeping up with our latest discoveries, upcoming events and more? Subscribe to our monthly newsletter, Discoveries.

Institute News

16th Annual SBP Postdoctoral Research Symposium

AuthorSusan Gammon
Date

September 22, 2017

Future scientific leaders gathered to attend SBP’s 16th Annual Postdoctoral Research Symposium—an event that showcased the talent of our young researchers, many of whom are in the midst of scholarly training beyond their doctoral degree.

The day began with a workshop led by Professor Carl Ware, PhD, titled, “Science Funding in Uncertain Times.” For the young scientists in the audience, they gleaned valuable insights on when and where they should seek funding, and the types of publications and collaborations they should aim for. As faculty positions in academia become increasingly competitive, a solid track record of funding, publications and collaborations become key measures used to make hiring decisions.

Keynote speaker Peter Schultz, PhD, CEO of The Scripps Research Institute, gave an impressive talk on his efforts to expand the genetic code. Schultz, a chemist by training, is inspired to create new amino acids, beyond the 20 essential ones in existence, to advance cancer therapies, create new vaccines, novel chemical probes and improved antibiotics. The audience was truly “wowed” by his vision and track record of achievements.

The agenda followed with 20-minute talks by postdocs including:

• David Sala Cano, PhD (Sacco Lab)
• Yang Wei, PhD (Petroski Lab)
• Maria Missinato, PhD (Colas Lab)
• Anjali Gupta, graduate student (Ocorr Lab)
• Marco Maruggi, graduate student (Powis Lab)
• Clyde Campbell (graduate student Dong Lab)
• Jing Yong, PhD (Kaufman Lab)
• Laura Martin-Sancho, PhD (Chanda Lab)

The event closed with a poster session featuring more than 30 presentations by SBP’s best and brightest young scientists. Many congratulations to all that participated in the Symposium, and thanks to the organizers at the Office of Education, Training, & International Services (OETIS) at SBP.

Institute News

Duc Dong, PhD, named associate dean of SBP’s Graduate Program

AuthorKristen Cusato
Date

June 8, 2017

There’s a new associate dean of the Graduate School of Biomedical Sciences at Sanford Burnham Prebys Medical Discovery Institute (SBP), and he is looking for diamonds in the rough.

Duc Dong, PhD, assistant professor in the Human Genetics Program, will now also coordinate the admissions process for SBP’s Graduate School of Biomedical Sciences. The School is an interdisciplinary program that awards PhD degrees to students with a desire to become a leading force in the next generation of biomedical scientists. As associate dean, Dong and members of the admission committee will identify talents students, and help place them with faculty advisors.

“I am excited because I’m passionate about educating students—and this lets me try something new,” says Dong. “SBP’s program is unique in that we look for applicants who already have a good idea of what they want to study. Most qualified candidates have already had significant lab experience so a big part of my job will be to help match them with faculty who can support and develop each student’s training and education.”

The graduate school was founded in 2005 and has awarded 29 PhD degrees to date. The school admits an average of eight students per year. Students are attracted to the program for many reasons, including, renowned faculty, access to cutting edge technology at SBP, collaborative research opportunities, and of course the incredible opportunity to live in San Diego.

“We are looking for diamonds in the rough,” Dong says. “We evaluate candidates on a range of criteria that include lab experience, independence, academic background, and their passion for science.

“The graduate program is a critical part of SBP—it helps us expand our scientific resources, helps draw new faculty to our Institute, and graduate students contribute fresh perspectives and ideas to research our programs. Equally as important, the students energize our campus, creating a unique culture focused on learning and sharing,” adds Dong. “This is a great place to be a graduate student.”

Institute News

Highlights from the Graduate School of Biomedical Sciences annual retreat

AuthorSusan Gammon
Date

May 24, 2017

On May 18-19, SBP’s Graduate School of Biomedical Sciences held its eighth annual retreat in San Marcos, Calif.

This year’s theme, “Using Collaborations to Enhance Your Research,” gave our PhD students an opportunity to share their research projects and explain how collaborators are helping them achieve their goals. At SBP, we encourage scientists to work with researchers in other disciplines to answer questions of broad scope and complexity—questions that would remain unanswered without collaboration.

At the retreat, each student presents their work and is scored by their fellow students, faculty and mentors on a scale of 1 to 9 for quality, content and clarity of presentation. When the scorecards are tallied, the winner is presented with the “Howling Coyote” award.

Wesley McKeithan, SBP Graduate School of Biomedical Sciences
Wesley L. McKeithan, graduate student in the lab of Mark Mercola, PhD

This year’s winner was Wesley L. McKeithan, a PhD candidate in the laboratory of Mark Mercola, PhD Wesley’s presentation, titled “Use of patient-derived long QT syndrome type 3 hiPSC cardiomyocytes to develop a new anti-arrhythmic therapeutic,” covered his scientific journey to find a treatment for this rare condition that can cause symptoms, which range from fainting to sudden death.

Highlights from the retreat included a presentation by keynote speaker Jerold Chun, MD, PhD, professor and senior vice president of Neuroscience Drug Discovery at SBP, who gave an inspirational success story of his research on lysophospholipid signaling that led to Gilenya®, the first oral drug used to treat multiple sclerosis.

Guest keynote speaker Bill Parks, PhD, professor at Cedars-Sinai Medical Center, led an entertaining interactive session on the do’s and don’t of collaboration—sharing his best experiences and some of the worst (without naming names).

Many congratulations to all of the student participants as well as Guy Salvesen, PhD, dean of the Graduate Program, for providing leadership and educational opportunities for the students.

Special thanks to:

  • Student coordinators, Katja Birker and Daniel Ojeda Juarez
  • Mary Bradley, manager of the graduate program, and Alexia Pimentel, program coordinator, for organizing the retreat
  • And to Pfizer, Genentech and Celgene for helping to underwrite the event