Rolf Bodmer Archives - Sanford Burnham Prebys
Institute News

Preuss School interns get an “A” grade at SBP

AuthorHelen I. Hwang
Date

August 4, 2017

“I got to do things I never thought I could do,” said Yadira Gomez Rangel, 16, a rising junior at Preuss School in San Diego. “I got a chance to dissect a fly, which I didn’t think I could do,” she told the audience at Sanford Burnham Prebys Medical Discovery Institute (SBP), which included SBP Trustees Malin Burnham and Wain Fishburn as well as CEO Perry Nisen, MD, PhD

Rangel is one of seven students from the prestigious Preuss School, who completed a two-week internship. Students from the Preuss School, affiliated with UC San Diego, strive to become the first in their families to graduate from college. The SBP Preuss program is designed to introduce young scientists-in-training to medical research by working hand in hand with our scientists.

The group of 16-year-olds got a chance to rotate among four different labs at SBP. The other students included Michelle Villa Bardales, Josué Barragán, Edizandro Morales Herrera, Arturo Torres Jimenez, Jenny Nguyen and Natalie Nguyen. Students presented posters in English and Spanish, received a certificate and a stipend for their hard work.

Fishburn said the Preuss program at SBP was “inspirational” as he hoped the young teens would continue their path in science. At the celebratory luncheon with students, their families and SBP staff, Fishburn chatted with Tommy Le, a Preuss School graduate. Le was part of the SBP Preuss program for the two-week internship, followed by a six-week internship the following year, and is now doing a summer internship at SBP before entering UC San Diego in the fall where he’ll major in biochemistry.

Each summer, SBP also hosts a six-week internship for rising Preuss seniors, sponsored by the NIH CURE program. Two of the seven interns (who happen to be all female), Gizelle Avitia Mejica and Julieta Morales Ornelas, also completed the two-week Preuss program, which inspired them to apply again at SBP. “About 90 percent of what I learned in the lab I wouldn’t have been taught in the classroom,” says Mejica.  

During the internship, the teenagers studied several aspects of medical research. They examined the correlation between obesity and heart disease in fruit flies in the laboratory of Rolf Bodmer, Ph.D. Also, the kids studied zebrafish and tackled the challenge of curing diabetes in the laboratory of Duc Dong, Ph.D. They looked at how to use C. elegans worms to understand the aging process in the laboratory of Malene Hansen, Ph.D. Finally, in the laboratory of Jing Crystal Zhou, Ph.D., the young scientists learned about RNA modification, a process that occurs in all living organisms and can influence how diseases occur.

With hands-on training and in-depth laboratory involvement, the Preuss students gained invaluable skills and networking opportunities. The program is made possible by founding philanthropists Peggy and Peter Preuss and Debby and Wain Fishburn. Jimenez said, “It’s been a wonderful experience!”

Preuss School Internship Program with SBP Trustees

 

Institute News

2017 BIO features SBP scientists

AuthorKristen Cusato
Date

June 19, 2017

Two SBP researchers will be sharing their knowledge and insights at the 2017 BIO International Convention, which will be held June 19th to the 22nd at the San Diego Convention Center.

Rolf Bodmer, PhD, professor in the Development, Aging and Regeneration Program, will be part of a panel on June 21st titled, “Reimagine Old Age: New Frontiers in the Science of Aging.”  Bodmer will highlight new biomedical research, as other panelists report on drugs that are presently in development and discuss how pharmaceutical companies are approaching new treatments for diseases related to aging.

 

“With our population aging, it becomes more important to understand and find ways to remedy the rapid decline and diseases that come with getting older,” Bodmer says. “We don’t necessarily need to live that much longer, but we need to find out how to have all of our organ systems work their best, to live healthier and happier as we age.”

 

Bodmer will also talk about the use of fruit fly models in his lab at SBP to study different aspects of aging, including cardiac function.

 

“Organisms like the fruit fly have an infinite box of genetic tools that can be used to figure out how our genetics and signaling pathways work. What we learn from them can help in the development of drugs for people with age-related diseases,” says Bodmer.

 

Rolf Bodmer, PhD

 

Reimagine Old Age: New Frontiers in the Science of Aging

 

June 21st 10:45am Room 6C upper level SDCC

Scott Peterson, PhD, professor in the Tumor Microenvironment and Cancer Immunology Program, will be on the “Microbiome 2.0: Going Beyond Bugs as Drugs” panel, also on June 21st.  Dr. Peterson’s focus will be on using prebiotics as a way of modulating or altering the gut microbiome to impact health.

Additional panelists will discuss new microbiome targets, novel approaches to regulate the gut-brain axis and how big data fits in.

“Beyond bugs as drugs means it’s no longer just about probiotics, now prebiotics have become part of the equation,” Peterson says. “We want to know if we can use pre-biotics to change someone’s microbiome to make them more responsive to certain drugs.”

Peterson says the translational aspect of microbiome research is starting to take form, and he is looking forward to talking about his research with potential new partners at BIO 2017 and beyond.

“NIH funding is hard to come by right now, and getting biotech interested in the microbiome will eventually benefit all of us.”

Scott Peterson, PhD

Microbiome 2.0: Going Beyond Bugs as Drugs

June 21st 4:15pm Room 6C upper level SDCC

Institute News

SBP’s 37th Annual Symposium: Aging and Regeneration

Authorsgammon
Date

November 3, 2015

On Friday, October 30, more 350 people came to SBP’s 37th Annual Symposium to hear leading scientists present their latest research on aging and regeneration.  The presenters, listed here, provided valuable insight into the latest studies on what causes aging, and strategies to repair injuries, prolong life, and prevent diseases.  The event was hosted by (from left to right): Rolf Bodmer, PhD, Malene Hansen, PhD, (in bee costume for Halloween) Alexey Terskikh, PhD

 

organizers-symposium-beaker

Many congratulations to Esther Minotti for successfully organizing the event!

symposium-photo-beaker

And many thanks to the Glenn Foundation for Medical Research for their support.

Institute News

Novel model for cardiomyopathy paves the way for new therapies

Authorsgammon
Date

May 29, 2015

A new fruit fly model that captures key metabolic defects associated with cardiomyopathy could translate into more-effective treatments for this potentially deadly heart condition, according to a study conducted by researchers at Sanford-Burnham and the Universidad Autónoma de Madrid in Spain. The findings, published April 9 in Human Molecular Genetics, could also have broader clinical implications for human metabolic diseases affecting other organ systems such as the liver and skeletal muscle. Continue reading “Novel model for cardiomyopathy paves the way for new therapies”

Institute News

New insights into how the heart forms may help identify heart defects

AuthorGuest Blogger
Date

September 29, 2014

This is a post by our guest writer Janelle Weaver, PhD

The formation of the heart during development is a highly complex process that requires precise coordination between cells and molecular signaling pathways. The fruit fly has been widely used for studying the underlying cellular and molecular mechanisms, and a great deal is known about how the fate of heart cells is controlled by signaling pathways and transcription factors—proteins that control gene activity. But beyond that, events that regulate heart formation have not been clear. Continue reading “New insights into how the heart forms may help identify heart defects”